Enhancement of human mesenchymal stem cell infiltration into the electrospun poly(lactic-co-glycolic acid) scaffold by fluid shear stress

Min Sung Kim, Mi Hee Lee, Byeong Ju Kwon, Min Ah Koo, Gyeung Mi Seon, Jongchul Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The infiltration of the cells into the scaffolds is important phenomenon to give them good biocompatibility and even biodegradability. Fluid shear stress is one of the candidates for the infiltration of cells into scaffolds. Here we investigated the directional migration of human mesenchymal stem cells and infiltration into PLGA scaffold by fluid shear stress. The human mesenchymal stem cells showed directional migrations following the direction of the flow (8, 16 dyne/cm2). In the scaffold models, the fluid shear stress (8 dyne/cm2) enhanced the infiltration of cells but did not influence on the infiltration of Poly(lactic-co-glycolic acid) particles.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume463
Issue number1-2
DOIs
Publication statusPublished - 2015 Jan 1

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Stem cells
Mesenchymal Stromal Cells
Infiltration
Scaffolds
Shear stress
Fluids
Biodegradability
Scaffolds (biology)
Biocompatibility
polylactic acid-polyglycolic acid copolymer

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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Enhancement of human mesenchymal stem cell infiltration into the electrospun poly(lactic-co-glycolic acid) scaffold by fluid shear stress. / Kim, Min Sung; Lee, Mi Hee; Kwon, Byeong Ju; Koo, Min Ah; Seon, Gyeung Mi; Park, Jongchul.

In: Biochemical and Biophysical Research Communications, Vol. 463, No. 1-2, 01.01.2015, p. 137-142.

Research output: Contribution to journalArticle

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AU - Seon, Gyeung Mi

AU - Park, Jongchul

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