Enhancement of mesenchymal stem cell-driven bone regeneration by resveratrol-mediated SOX2 regulation

Yoorim Choi, Dong Suk Yoon, Kyoung Mi Lee, Seong Mi Choi, Myon Hee Lee, Kwang Hwan Park, Seung Hwan Han, Jin Woo Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) are an attractive cell source for regenerative medicine. However, MSCs age rapidly during long-term ex vivoculture and lose their therapeutic potential before they reach effective cell doses (ECD) for cell therapy. Thus, a prerequisite for effective MSC therapy is the development of cell culture methods to preserve the therapeutic potential during long-term ex vivo cultivation. Resveratrol (RSV) has been highlighted as a therapeutic candidate for bone disease. Although RSV treatment has beneficial effects on bone-forming cells,invivostudies are lacking.The current study showed that long-term (6 weeks from primary culture date)-cultured MSCs with RSV induction retained their proliferative and differentiation potential despite reaching ECD. The mechanism of RSV action depends entirely on the SIRT1-SOX2 axis in MSC culture. In a rat calvarial defect model, RSV induction significantly improved bone regeneration after MSC transplantation. This study demonstrated an example of efficient MSC therapy for treating bone defects by providing a new strategy using the plant polyphenol RSV.

Original languageEnglish
Pages (from-to)818-833
Number of pages16
JournalAging and Disease
Volume10
Issue number4
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cell Biology

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