TY - JOUR
T1 - Enhancement of monascus pigment production by the culture of Monascus sp. J101 at low temperature
AU - Ahn, Jungoh
AU - Jung, Joonki
AU - Hyung, Woochan
AU - Haam, Seungjoo
AU - Shin, Chulsoo
PY - 2006/1
Y1 - 2006/1
N2 - In general, high broth viscosity is a key factor to be considered in a submerged fermentation of filamentous fungi. High broth viscosity was also observed in a batch fermentation of Monascus sp. J101 at 30°C. In a batch culture at 30°C, most cell growth was accomplished within 48 h, which induced highly entangled clumps. The resultant high viscosity induced heterogeneity inside the fermentor, poor oxygen transfer, and low pigment yield. However, these problems could be overcome by reducing fungal growth rate through culture at low temperature (25°C). Cell growth was moderate and continued for 120 h, and low viscosity was maintained. The DO levels remained at 50% or higher with good mixing. As a result, the pigment yield at 25°C was 10 times greater than at 30°C.
AB - In general, high broth viscosity is a key factor to be considered in a submerged fermentation of filamentous fungi. High broth viscosity was also observed in a batch fermentation of Monascus sp. J101 at 30°C. In a batch culture at 30°C, most cell growth was accomplished within 48 h, which induced highly entangled clumps. The resultant high viscosity induced heterogeneity inside the fermentor, poor oxygen transfer, and low pigment yield. However, these problems could be overcome by reducing fungal growth rate through culture at low temperature (25°C). Cell growth was moderate and continued for 120 h, and low viscosity was maintained. The DO levels remained at 50% or higher with good mixing. As a result, the pigment yield at 25°C was 10 times greater than at 30°C.
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U2 - 10.1021/bp050275o
DO - 10.1021/bp050275o
M3 - Article
C2 - 16454530
AN - SCOPUS:32344435798
VL - 22
SP - 338
EP - 340
JO - Biotechnology Progress
JF - Biotechnology Progress
SN - 8756-7938
IS - 1
ER -