Enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage

Eun Mi Choi, Jae Kwan Hwang

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29 Citations (Scopus)

Abstract

Yam (Dioscorea batatas) mucopolysaccharide (YMP) was examined for the ability to induce secretory and cellular responses in murine peritoneal macrophages. When macrophages were treated with various doses (10-100 μg/ml) of YMP for 48 h, a significant cytotoxicity against B 16 cells was observed. YMP also increased the myeloperoxidase activity and the production of H2O2, O2-, nitric oxide (NO) and tumor necrosis factor (TNF-α). However, there was a little alteration on the production of IFN-γ. These results indicate that reactive oxygen intermediates (ROI), reactive nitrogen intermediates (RNI) and TNF-α are likely major mediators of cytotoxic activity of YMP-treated macrophages.

Original languageEnglish
Pages (from-to)629-637
Number of pages9
JournalFitoterapia
Volume73
Issue number7-8
DOIs
Publication statusPublished - 2002 Dec 1

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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