Enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage

Eun Mi Choi, Jae Kwan Hwang

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29 Citations (Scopus)


Yam (Dioscorea batatas) mucopolysaccharide (YMP) was examined for the ability to induce secretory and cellular responses in murine peritoneal macrophages. When macrophages were treated with various doses (10-100 μg/ml) of YMP for 48 h, a significant cytotoxicity against B 16 cells was observed. YMP also increased the myeloperoxidase activity and the production of H2O2, O2-, nitric oxide (NO) and tumor necrosis factor (TNF-α). However, there was a little alteration on the production of IFN-γ. These results indicate that reactive oxygen intermediates (ROI), reactive nitrogen intermediates (RNI) and TNF-α are likely major mediators of cytotoxic activity of YMP-treated macrophages.

Original languageEnglish
Pages (from-to)629-637
Number of pages9
Issue number7-8
Publication statusPublished - 2002 Dec 1


All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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