Abstract
Metagenomic studies show that diverse resident viruses inhabit the healthy gut; however, little is known about the role of these viruses in the maintenance of gut homeostasis. We found that mice treated with antiviral cocktail displayed more severe dextran sulfate sodium (DSS)-induced colitis compared with untreated mice. DSS-induced colitis was associated with altered enteric viral abundance and composition. When wild-type mice were reconstituted with Toll-like receptor 3 (TLR3) or TLR7 agonists or inactivated rotavirus, colitis symptoms were significantly ameliorated. Mice deficient in both TLR3 and TLR7 were more susceptible to DSS-induced experimental colitis. In humans, combined TLR3 and TLR7 genetic variations significantly influenced the severity of ulcerative colitis. Plasmacytoid dendritic cells isolated from inflamed mouse colon produced interferon-β in a TLR3 and TLR7-dependent manner. These results imply that recognition of resident viruses by TLR3 and TLR7 is required for protective immunity during gut inflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 889-900 |
| Number of pages | 12 |
| Journal | Immunity |
| Volume | 44 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2016 Apr 19 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Infectious Diseases
Cite this
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Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production. / Yang, Jin Young; Kim, Min Soo; Kim, Eugene; Cheon, Jae Hee; Lee, Yong Soo; Kim, Yeji; Lee, Su Hyun; Seo, Sang Uk; Shin, Seung Ho; Choi, Sun Shim; Kim, Bumseok; Chang, Sun Young; Ko, Hyun Jeong; Bae, Jin Woo; Kweon, Mi Na.
In: Immunity, Vol. 44, No. 4, 19.04.2016, p. 889-900.Research output: Contribution to journal › Article
TY - JOUR
T1 - Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production
AU - Yang, Jin Young
AU - Kim, Min Soo
AU - Kim, Eugene
AU - Cheon, Jae Hee
AU - Lee, Yong Soo
AU - Kim, Yeji
AU - Lee, Su Hyun
AU - Seo, Sang Uk
AU - Shin, Seung Ho
AU - Choi, Sun Shim
AU - Kim, Bumseok
AU - Chang, Sun Young
AU - Ko, Hyun Jeong
AU - Bae, Jin Woo
AU - Kweon, Mi Na
PY - 2016/4/19
Y1 - 2016/4/19
N2 - Metagenomic studies show that diverse resident viruses inhabit the healthy gut; however, little is known about the role of these viruses in the maintenance of gut homeostasis. We found that mice treated with antiviral cocktail displayed more severe dextran sulfate sodium (DSS)-induced colitis compared with untreated mice. DSS-induced colitis was associated with altered enteric viral abundance and composition. When wild-type mice were reconstituted with Toll-like receptor 3 (TLR3) or TLR7 agonists or inactivated rotavirus, colitis symptoms were significantly ameliorated. Mice deficient in both TLR3 and TLR7 were more susceptible to DSS-induced experimental colitis. In humans, combined TLR3 and TLR7 genetic variations significantly influenced the severity of ulcerative colitis. Plasmacytoid dendritic cells isolated from inflamed mouse colon produced interferon-β in a TLR3 and TLR7-dependent manner. These results imply that recognition of resident viruses by TLR3 and TLR7 is required for protective immunity during gut inflammation.
AB - Metagenomic studies show that diverse resident viruses inhabit the healthy gut; however, little is known about the role of these viruses in the maintenance of gut homeostasis. We found that mice treated with antiviral cocktail displayed more severe dextran sulfate sodium (DSS)-induced colitis compared with untreated mice. DSS-induced colitis was associated with altered enteric viral abundance and composition. When wild-type mice were reconstituted with Toll-like receptor 3 (TLR3) or TLR7 agonists or inactivated rotavirus, colitis symptoms were significantly ameliorated. Mice deficient in both TLR3 and TLR7 were more susceptible to DSS-induced experimental colitis. In humans, combined TLR3 and TLR7 genetic variations significantly influenced the severity of ulcerative colitis. Plasmacytoid dendritic cells isolated from inflamed mouse colon produced interferon-β in a TLR3 and TLR7-dependent manner. These results imply that recognition of resident viruses by TLR3 and TLR7 is required for protective immunity during gut inflammation.
UR - http://www.scopus.com/inward/record.url?scp=84963959977&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84963959977&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2016.03.009
DO - 10.1016/j.immuni.2016.03.009
M3 - Article
C2 - 27084119
AN - SCOPUS:84963959977
VL - 44
SP - 889
EP - 900
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 4
ER -