Environmental enrichment attenuates oxidative stress and alters detoxifying enzymes in an a53t α-synuclein transgenic mouse model of Parkinson’s disease

Jung Hwa Seo, Seong Woong Kang, Kyungri Kim, Soohyun Wi, Jang Woo Lee, Sung Rae Cho

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1 Citation (Scopus)

Abstract

Although environmental enrichment (EE) is known to reduce oxidative stress in Parkinson’s disease (PD), the metabolic alternations for detoxifying endogenous and xenobiotic compounds according to various brain regions are not fully elucidated yet. This study aimed to further understand the role of EE on detoxifying enzymes, especially those participating in phase I of metabolism, by investigating the levels of enzymes in various brain regions such as the olfactory bulb, brain stem, frontal cortex, and striatum. Eight-month-old transgenic PD mice with the overexpression of human A53T α-synuclein and wild-type mice were randomly allocated to either standard cage condition or EE for 2 months. At 10 months of age, the expression of detoxifying enzymes was evaluated and compared with wild-type of the same age raised in standard cages. EE improved neurobehavioral outcomes such as olfactory and motor function in PD mice. EE-treated mice showed that oxidative stress was attenuated in the olfactory bulb, brain stem, and frontal cortex. EE also reduced apoptosis and induced cell proliferation in the subventricular zone of PD mice. The overexpression of detoxifying enzymes was observed in the olfactory bulb and brain stem of PD mice, which was ameliorated by EE. These findings were not apparent in the other experimental regions. These results suggest the stage of PD pathogenesis may differ according to brain region, and that EE has a protective effect on the PD pathogenesis by decreasing oxidative stress.

Original languageEnglish
Article number928
Pages (from-to)1-17
Number of pages17
JournalAntioxidants
Volume9
Issue number10
DOIs
Publication statusPublished - 2020 Oct

Bibliographical note

Funding Information:
Funding: This work was supported by grants from the National Research Foundation (NRF-2019R1I1A1A01062098), the Ministry of Science and Technology, Republic of Korea; the Korean Health Technology R&D Project (HI16C1012), Republic of Korea; and a faculty research grant of Yonsei University College of Medicine (6-2020-0104).

Funding Information:
This work was supported by grants from the National Research Foundation (NRF-2019R1I1A1A01062098), the Ministry of Science and Technology, Republic of Korea; the Korean Health Technology R&D Project (HI16C1012), Republic of Korea; and a faculty research grant of Yonsei University College of Medicine (6-2020-0104).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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