Eosinophil count and eosinophil cationic protein concentration of induced sputum in the diagnosis and assessment of airway inflammation in bronchial asthma

Jungwon Park, Young Woong Whang, Cheol Woo Kim, Young Bum Park, Chein Soo Hong

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Measurement of eosinophil percentages and ECP concentration in induced sputum may be useful in the diagnosis and assessment of the variability of airway inflammation in bronchial asthma (BA). To evaluate the usefulness of sputum eosinophil counts and ECP concentrations in the diagnosis of BA, we measured these parameters in 68 patients with respiratory complaints. In addition, wefollowed-up 14 BA patients with variable airflow limitation for 45.4 ± 10.4 days. The BA group (n = 41) showed a higher percentage of sputum eosinophilia (24.5 ± 7.6 vs. 2.2 ± 2.9%, p < 0.001) and a higher level of sputum ECP (198.2 vs. 90.6 μg/L, p < 0.05) than those in the nonasthmatic group (NBA, n = 27). The sensitivity and specificity of sputum eosinophilia (≥5%) for the diagnosis of BA were 85.4% and 92.6%, respectively, which were better than the sensitivity (68.3%) and specificity (55.5%) of the increased level of sputum ECP (≥100 μg/L). Patients with moderate-to-severe persistent BA had a higher percentage of sputum eosinophil (n = 23, 34,6 ± 10.6%) than those of mild persistent BA (n = 18, 10.7 ± 5.2%, p < 0.01), but we could not find significant difference in ECP levels between mild persistent and moderate-to-severe persistent asthma. The percentages of sputum eosinophilia showed a moderate correlation with ECP (r = 0.4358, p < 0.07,) and with the peak expiratory flow rate (PFR, r = -0.4746, p < 0.01) but sputum ECP did not correlate with PFR. In 14 BA patients who were followed, there was a relationship between changes of PFR and the percentage of sputum eosinophil (r = -0.7238, p < 0.01), but the change of PFR did not correlate with the change of sputum ECP levels. These results suggest that the sputum eosinophil count and sputum ECP level could be helpful in the diagnosis of BA, but that sputum ECP is not satisfactory for the assessment of variability of airway eosinophilic inflammation during the initial anti-inflammatory management of BA.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalAllergy and Asthma Proceedings
Volume19
Issue number2
DOIs
Publication statusPublished - 1998 Jan 1

Fingerprint

Eosinophil Cationic Protein
Sputum
Eosinophils
Asthma
Inflammation
Eosinophilia
Peak Expiratory Flow Rate
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

@article{14f7994e43bd4c608aa3b00fba1116d0,
title = "Eosinophil count and eosinophil cationic protein concentration of induced sputum in the diagnosis and assessment of airway inflammation in bronchial asthma",
abstract = "Measurement of eosinophil percentages and ECP concentration in induced sputum may be useful in the diagnosis and assessment of the variability of airway inflammation in bronchial asthma (BA). To evaluate the usefulness of sputum eosinophil counts and ECP concentrations in the diagnosis of BA, we measured these parameters in 68 patients with respiratory complaints. In addition, wefollowed-up 14 BA patients with variable airflow limitation for 45.4 ± 10.4 days. The BA group (n = 41) showed a higher percentage of sputum eosinophilia (24.5 ± 7.6 vs. 2.2 ± 2.9{\%}, p < 0.001) and a higher level of sputum ECP (198.2 vs. 90.6 μg/L, p < 0.05) than those in the nonasthmatic group (NBA, n = 27). The sensitivity and specificity of sputum eosinophilia (≥5{\%}) for the diagnosis of BA were 85.4{\%} and 92.6{\%}, respectively, which were better than the sensitivity (68.3{\%}) and specificity (55.5{\%}) of the increased level of sputum ECP (≥100 μg/L). Patients with moderate-to-severe persistent BA had a higher percentage of sputum eosinophil (n = 23, 34,6 ± 10.6{\%}) than those of mild persistent BA (n = 18, 10.7 ± 5.2{\%}, p < 0.01), but we could not find significant difference in ECP levels between mild persistent and moderate-to-severe persistent asthma. The percentages of sputum eosinophilia showed a moderate correlation with ECP (r = 0.4358, p < 0.07,) and with the peak expiratory flow rate (PFR, r = -0.4746, p < 0.01) but sputum ECP did not correlate with PFR. In 14 BA patients who were followed, there was a relationship between changes of PFR and the percentage of sputum eosinophil (r = -0.7238, p < 0.01), but the change of PFR did not correlate with the change of sputum ECP levels. These results suggest that the sputum eosinophil count and sputum ECP level could be helpful in the diagnosis of BA, but that sputum ECP is not satisfactory for the assessment of variability of airway eosinophilic inflammation during the initial anti-inflammatory management of BA.",
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Eosinophil count and eosinophil cationic protein concentration of induced sputum in the diagnosis and assessment of airway inflammation in bronchial asthma. / Park, Jungwon; Whang, Young Woong; Kim, Cheol Woo; Park, Young Bum; Hong, Chein Soo.

In: Allergy and Asthma Proceedings, Vol. 19, No. 2, 01.01.1998, p. 61-67.

Research output: Contribution to journalArticle

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T1 - Eosinophil count and eosinophil cationic protein concentration of induced sputum in the diagnosis and assessment of airway inflammation in bronchial asthma

AU - Park, Jungwon

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AU - Hong, Chein Soo

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N2 - Measurement of eosinophil percentages and ECP concentration in induced sputum may be useful in the diagnosis and assessment of the variability of airway inflammation in bronchial asthma (BA). To evaluate the usefulness of sputum eosinophil counts and ECP concentrations in the diagnosis of BA, we measured these parameters in 68 patients with respiratory complaints. In addition, wefollowed-up 14 BA patients with variable airflow limitation for 45.4 ± 10.4 days. The BA group (n = 41) showed a higher percentage of sputum eosinophilia (24.5 ± 7.6 vs. 2.2 ± 2.9%, p < 0.001) and a higher level of sputum ECP (198.2 vs. 90.6 μg/L, p < 0.05) than those in the nonasthmatic group (NBA, n = 27). The sensitivity and specificity of sputum eosinophilia (≥5%) for the diagnosis of BA were 85.4% and 92.6%, respectively, which were better than the sensitivity (68.3%) and specificity (55.5%) of the increased level of sputum ECP (≥100 μg/L). Patients with moderate-to-severe persistent BA had a higher percentage of sputum eosinophil (n = 23, 34,6 ± 10.6%) than those of mild persistent BA (n = 18, 10.7 ± 5.2%, p < 0.01), but we could not find significant difference in ECP levels between mild persistent and moderate-to-severe persistent asthma. The percentages of sputum eosinophilia showed a moderate correlation with ECP (r = 0.4358, p < 0.07,) and with the peak expiratory flow rate (PFR, r = -0.4746, p < 0.01) but sputum ECP did not correlate with PFR. In 14 BA patients who were followed, there was a relationship between changes of PFR and the percentage of sputum eosinophil (r = -0.7238, p < 0.01), but the change of PFR did not correlate with the change of sputum ECP levels. These results suggest that the sputum eosinophil count and sputum ECP level could be helpful in the diagnosis of BA, but that sputum ECP is not satisfactory for the assessment of variability of airway eosinophilic inflammation during the initial anti-inflammatory management of BA.

AB - Measurement of eosinophil percentages and ECP concentration in induced sputum may be useful in the diagnosis and assessment of the variability of airway inflammation in bronchial asthma (BA). To evaluate the usefulness of sputum eosinophil counts and ECP concentrations in the diagnosis of BA, we measured these parameters in 68 patients with respiratory complaints. In addition, wefollowed-up 14 BA patients with variable airflow limitation for 45.4 ± 10.4 days. The BA group (n = 41) showed a higher percentage of sputum eosinophilia (24.5 ± 7.6 vs. 2.2 ± 2.9%, p < 0.001) and a higher level of sputum ECP (198.2 vs. 90.6 μg/L, p < 0.05) than those in the nonasthmatic group (NBA, n = 27). The sensitivity and specificity of sputum eosinophilia (≥5%) for the diagnosis of BA were 85.4% and 92.6%, respectively, which were better than the sensitivity (68.3%) and specificity (55.5%) of the increased level of sputum ECP (≥100 μg/L). Patients with moderate-to-severe persistent BA had a higher percentage of sputum eosinophil (n = 23, 34,6 ± 10.6%) than those of mild persistent BA (n = 18, 10.7 ± 5.2%, p < 0.01), but we could not find significant difference in ECP levels between mild persistent and moderate-to-severe persistent asthma. The percentages of sputum eosinophilia showed a moderate correlation with ECP (r = 0.4358, p < 0.07,) and with the peak expiratory flow rate (PFR, r = -0.4746, p < 0.01) but sputum ECP did not correlate with PFR. In 14 BA patients who were followed, there was a relationship between changes of PFR and the percentage of sputum eosinophil (r = -0.7238, p < 0.01), but the change of PFR did not correlate with the change of sputum ECP levels. These results suggest that the sputum eosinophil count and sputum ECP level could be helpful in the diagnosis of BA, but that sputum ECP is not satisfactory for the assessment of variability of airway eosinophilic inflammation during the initial anti-inflammatory management of BA.

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