Eosinophilic granulomatosis with polyangiitis: Experiences in korean patients

Chan Bum Choi, Yong Beom Park, Sang Won Lee

Research output: Contribution to journalReview article

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is one form of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Identical to what has been called Churg-Strauss syndrome, EGPA exhibits both allergic and vasculitis features. EGPA was first described as a syndrome consisting of asthma, fever, eosinophilia, and organ involvement including heart failure, neuropathy, and kidney damage, by Churg and Strauss in 1951. On the basis of the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis, EGPA comprises three typical allergic components, including asthma, peripheral eosinophilia, and eosinophil-rich granuloma of the respiratory tracts. EGPA has three clinical and histological stages. The first is an allergic stage composed of asthma and sinusitis, and the second is an eosinophilic stage characterised by peripheral hypereosinophilia and intra-organ infiltration of eosinophils. The last is a vasculitic stage, including necrotising inflammation of small vessels and end-organ damage. In this review, we describe the classification criteria for EGPA and recommendations for the evaluation and management of EGPA with conventional and newly suggested drugs for EGPA. Also, we discuss a variety of clinical aspects such as predictive values for prognosis and associations with other Th2-mediated diseases and hepatitis B virus.

Original languageEnglish
Pages (from-to)705-712
Number of pages8
JournalYonsei medical journal
Volume60
Issue number8
DOIs
Publication statusPublished - 2019 Aug

Fingerprint

Granulomatosis with Polyangiitis
Vasculitis
Asthma
Eosinophilia
Respiratory Tract Granuloma
Eosinophils
Churg-Strauss Syndrome
Antineutrophil Cytoplasmic Antibodies
Sinusitis
Terminology
Hepatitis B virus
Fever
Heart Failure
Inflammation
Kidney

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{9aa4698110404dfebc78f7029ceda45b,
title = "Eosinophilic granulomatosis with polyangiitis: Experiences in korean patients",
abstract = "Eosinophilic granulomatosis with polyangiitis (EGPA) is one form of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Identical to what has been called Churg-Strauss syndrome, EGPA exhibits both allergic and vasculitis features. EGPA was first described as a syndrome consisting of asthma, fever, eosinophilia, and organ involvement including heart failure, neuropathy, and kidney damage, by Churg and Strauss in 1951. On the basis of the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis, EGPA comprises three typical allergic components, including asthma, peripheral eosinophilia, and eosinophil-rich granuloma of the respiratory tracts. EGPA has three clinical and histological stages. The first is an allergic stage composed of asthma and sinusitis, and the second is an eosinophilic stage characterised by peripheral hypereosinophilia and intra-organ infiltration of eosinophils. The last is a vasculitic stage, including necrotising inflammation of small vessels and end-organ damage. In this review, we describe the classification criteria for EGPA and recommendations for the evaluation and management of EGPA with conventional and newly suggested drugs for EGPA. Also, we discuss a variety of clinical aspects such as predictive values for prognosis and associations with other Th2-mediated diseases and hepatitis B virus.",
author = "Choi, {Chan Bum} and Park, {Yong Beom} and Lee, {Sang Won}",
year = "2019",
month = "8",
doi = "10.3349/ymj.2019.60.8.705",
language = "English",
volume = "60",
pages = "705--712",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "8",

}

Eosinophilic granulomatosis with polyangiitis : Experiences in korean patients. / Choi, Chan Bum; Park, Yong Beom; Lee, Sang Won.

In: Yonsei medical journal, Vol. 60, No. 8, 08.2019, p. 705-712.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Eosinophilic granulomatosis with polyangiitis

T2 - Experiences in korean patients

AU - Choi, Chan Bum

AU - Park, Yong Beom

AU - Lee, Sang Won

PY - 2019/8

Y1 - 2019/8

N2 - Eosinophilic granulomatosis with polyangiitis (EGPA) is one form of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Identical to what has been called Churg-Strauss syndrome, EGPA exhibits both allergic and vasculitis features. EGPA was first described as a syndrome consisting of asthma, fever, eosinophilia, and organ involvement including heart failure, neuropathy, and kidney damage, by Churg and Strauss in 1951. On the basis of the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis, EGPA comprises three typical allergic components, including asthma, peripheral eosinophilia, and eosinophil-rich granuloma of the respiratory tracts. EGPA has three clinical and histological stages. The first is an allergic stage composed of asthma and sinusitis, and the second is an eosinophilic stage characterised by peripheral hypereosinophilia and intra-organ infiltration of eosinophils. The last is a vasculitic stage, including necrotising inflammation of small vessels and end-organ damage. In this review, we describe the classification criteria for EGPA and recommendations for the evaluation and management of EGPA with conventional and newly suggested drugs for EGPA. Also, we discuss a variety of clinical aspects such as predictive values for prognosis and associations with other Th2-mediated diseases and hepatitis B virus.

AB - Eosinophilic granulomatosis with polyangiitis (EGPA) is one form of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Identical to what has been called Churg-Strauss syndrome, EGPA exhibits both allergic and vasculitis features. EGPA was first described as a syndrome consisting of asthma, fever, eosinophilia, and organ involvement including heart failure, neuropathy, and kidney damage, by Churg and Strauss in 1951. On the basis of the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis, EGPA comprises three typical allergic components, including asthma, peripheral eosinophilia, and eosinophil-rich granuloma of the respiratory tracts. EGPA has three clinical and histological stages. The first is an allergic stage composed of asthma and sinusitis, and the second is an eosinophilic stage characterised by peripheral hypereosinophilia and intra-organ infiltration of eosinophils. The last is a vasculitic stage, including necrotising inflammation of small vessels and end-organ damage. In this review, we describe the classification criteria for EGPA and recommendations for the evaluation and management of EGPA with conventional and newly suggested drugs for EGPA. Also, we discuss a variety of clinical aspects such as predictive values for prognosis and associations with other Th2-mediated diseases and hepatitis B virus.

UR - http://www.scopus.com/inward/record.url?scp=85070701359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070701359&partnerID=8YFLogxK

U2 - 10.3349/ymj.2019.60.8.705

DO - 10.3349/ymj.2019.60.8.705

M3 - Review article

C2 - 31347324

AN - SCOPUS:85070701359

VL - 60

SP - 705

EP - 712

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 8

ER -