Eosinophilic/T-cell chorionic vasculitis: A clinicopathologic and immunohistochemical study of 51 cases

Suzanne M. Jacques, Faisal Qureshi, Chong Jai Kim, JoonHo Lee, Tamar Giorgadze, Pooja Mittal, Sonia S. Hassan, Roberto Romero

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We report 51 placentas diagnosed with eosinophilic/T-cell chorionic vasculitis (E/TCV), an unusual form of chorionic vasculitis characterized by an infiltrate composed predominantly of CD3+ T cells and eosinophils. The placentas were all 3rd trimester, with 48 (94.1%) being term. Forty-seven (92.2%) were singleton placentas, and the remaining 4 were twins. The E/TCV was limited to 1 chorionic surface vessel in 40 (78.4%) and involved 50% or less of the vessel circumference in 30 (58.8%) placentas. The inflammation faced the intervillous space in 12 (23.5%) and the amniotic cavity in 8 (15.7%) and had no distinct predominant direction in the remaining 31 (60.8%) placentas. Twelve (25.5%) placentas showed mural thrombi or intramural fibrin in association with the E/TCV. One hundred six term singleton placentas were selected as the control group, and the 47 singleton placentas with E/TCV made up the study group for comparison of demographic and histopathologic features. Villitis of unknown etiology was identified more frequently in study group placentas (20 [42.6%]) compared with control group placentas (14 [13.2%]) (P < 0.001). Vascular changes of fetal vascular thrombo-occlusive disease were identified away from the E/TCV more frequently in study group placentas (8 [17.0%]) compared with control group placentas (4 [3.8%]) (P = 0.008). There were no significant differences in the frequencies of other placental lesions studied, including acute inflammatory lesions and lesions related to maternal underperfusion. There were no significant differences in maternal age, race, parity, birth weight, allergy history, blood type, or medication use.

Original languageEnglish
Pages (from-to)198-205
Number of pages8
JournalPediatric and Developmental Pathology
Volume14
Issue number3
DOIs
Publication statusPublished - 2011 May 1

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Vasculitis
Placenta
T-Lymphocytes
Control Groups
Blood Vessels
Maternal Age
Parity
Fibrin
Eosinophils
Birth Weight
Hypersensitivity
Thrombosis
Mothers
Demography
Inflammation

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Jacques, Suzanne M. ; Qureshi, Faisal ; Kim, Chong Jai ; Lee, JoonHo ; Giorgadze, Tamar ; Mittal, Pooja ; Hassan, Sonia S. ; Romero, Roberto. / Eosinophilic/T-cell chorionic vasculitis : A clinicopathologic and immunohistochemical study of 51 cases. In: Pediatric and Developmental Pathology. 2011 ; Vol. 14, No. 3. pp. 198-205.
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abstract = "We report 51 placentas diagnosed with eosinophilic/T-cell chorionic vasculitis (E/TCV), an unusual form of chorionic vasculitis characterized by an infiltrate composed predominantly of CD3+ T cells and eosinophils. The placentas were all 3rd trimester, with 48 (94.1{\%}) being term. Forty-seven (92.2{\%}) were singleton placentas, and the remaining 4 were twins. The E/TCV was limited to 1 chorionic surface vessel in 40 (78.4{\%}) and involved 50{\%} or less of the vessel circumference in 30 (58.8{\%}) placentas. The inflammation faced the intervillous space in 12 (23.5{\%}) and the amniotic cavity in 8 (15.7{\%}) and had no distinct predominant direction in the remaining 31 (60.8{\%}) placentas. Twelve (25.5{\%}) placentas showed mural thrombi or intramural fibrin in association with the E/TCV. One hundred six term singleton placentas were selected as the control group, and the 47 singleton placentas with E/TCV made up the study group for comparison of demographic and histopathologic features. Villitis of unknown etiology was identified more frequently in study group placentas (20 [42.6{\%}]) compared with control group placentas (14 [13.2{\%}]) (P < 0.001). Vascular changes of fetal vascular thrombo-occlusive disease were identified away from the E/TCV more frequently in study group placentas (8 [17.0{\%}]) compared with control group placentas (4 [3.8{\%}]) (P = 0.008). There were no significant differences in the frequencies of other placental lesions studied, including acute inflammatory lesions and lesions related to maternal underperfusion. There were no significant differences in maternal age, race, parity, birth weight, allergy history, blood type, or medication use.",
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Eosinophilic/T-cell chorionic vasculitis : A clinicopathologic and immunohistochemical study of 51 cases. / Jacques, Suzanne M.; Qureshi, Faisal; Kim, Chong Jai; Lee, JoonHo; Giorgadze, Tamar; Mittal, Pooja; Hassan, Sonia S.; Romero, Roberto.

In: Pediatric and Developmental Pathology, Vol. 14, No. 3, 01.05.2011, p. 198-205.

Research output: Contribution to journalArticle

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AU - Jacques, Suzanne M.

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AB - We report 51 placentas diagnosed with eosinophilic/T-cell chorionic vasculitis (E/TCV), an unusual form of chorionic vasculitis characterized by an infiltrate composed predominantly of CD3+ T cells and eosinophils. The placentas were all 3rd trimester, with 48 (94.1%) being term. Forty-seven (92.2%) were singleton placentas, and the remaining 4 were twins. The E/TCV was limited to 1 chorionic surface vessel in 40 (78.4%) and involved 50% or less of the vessel circumference in 30 (58.8%) placentas. The inflammation faced the intervillous space in 12 (23.5%) and the amniotic cavity in 8 (15.7%) and had no distinct predominant direction in the remaining 31 (60.8%) placentas. Twelve (25.5%) placentas showed mural thrombi or intramural fibrin in association with the E/TCV. One hundred six term singleton placentas were selected as the control group, and the 47 singleton placentas with E/TCV made up the study group for comparison of demographic and histopathologic features. Villitis of unknown etiology was identified more frequently in study group placentas (20 [42.6%]) compared with control group placentas (14 [13.2%]) (P < 0.001). Vascular changes of fetal vascular thrombo-occlusive disease were identified away from the E/TCV more frequently in study group placentas (8 [17.0%]) compared with control group placentas (4 [3.8%]) (P = 0.008). There were no significant differences in the frequencies of other placental lesions studied, including acute inflammatory lesions and lesions related to maternal underperfusion. There were no significant differences in maternal age, race, parity, birth weight, allergy history, blood type, or medication use.

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