Epidemiologic trends and clinical features of pneumocystis jirovecii pneumonia in non-HIV patients in a tertiary-care hospital in Korea over a 15-year-period

Hye Young Lee, Sang Ho Choi, Tark Kim, Jeonghyun Chang, Sung Han Kim, Sang Oh Lee, Mi Na Kim, Heungsup Sung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Subsequent to the increasing use of immunosuppressant therapy, Pneumocystis jirovecii pneumonia (PcP) has emerged as a life-threatening condition in human immunodeficiency virus (HIV)- negative patients. We investigated changes in epidemiological and clinical characteristics among PcP cases with and without HIV infections. Data of 424 patients diagnosed with PcP in a 2,700-bed Korean tertiary care hospital between February 2003 and April 2017 were retrospectively analyzed. The study included patients with compatible clinical findings in whom PcP was confirmed via direct immunofluorescence assay. The annual average number of cases increased from 12.2 (initial 5-year period) to 42.2 (recent 5-year period). In HIV-negative patients, hematologic malignancy (34.8%) and solid organ transplantation (32.9%) were the most frequent major underlying conditions, and immunosuppressive therapies including corticosteroids (342/362, 94.5%) and chemotherapy (122/362, 33.7%) were significantly associated with PcP infection (p < 0.001 for both). The incidence of PcP has continued to increase among non-HIV-infected immunocompromised patients in recent years.

Original languageEnglish
Pages (from-to)270-273
Number of pages4
JournalJapanese journal of infectious diseases
Volume72
Issue number4
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Pneumocystis carinii
Pneumocystis Pneumonia
Tertiary Healthcare
Korea
Tertiary Care Centers
Viruses
HIV
Immunosuppressive Agents
Direct Fluorescent Antibody Technique
Immunocompromised Host
Organ Transplantation
Virus Diseases
Hematologic Neoplasms
Adrenal Cortex Hormones
Drug Therapy
Incidence
Therapeutics
Infection

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Lee, Hye Young ; Choi, Sang Ho ; Kim, Tark ; Chang, Jeonghyun ; Kim, Sung Han ; Lee, Sang Oh ; Kim, Mi Na ; Sung, Heungsup. / Epidemiologic trends and clinical features of pneumocystis jirovecii pneumonia in non-HIV patients in a tertiary-care hospital in Korea over a 15-year-period. In: Japanese journal of infectious diseases. 2019 ; Vol. 72, No. 4. pp. 270-273.
@article{dafab662ad4d45ac84f66673368976bc,
title = "Epidemiologic trends and clinical features of pneumocystis jirovecii pneumonia in non-HIV patients in a tertiary-care hospital in Korea over a 15-year-period",
abstract = "Subsequent to the increasing use of immunosuppressant therapy, Pneumocystis jirovecii pneumonia (PcP) has emerged as a life-threatening condition in human immunodeficiency virus (HIV)- negative patients. We investigated changes in epidemiological and clinical characteristics among PcP cases with and without HIV infections. Data of 424 patients diagnosed with PcP in a 2,700-bed Korean tertiary care hospital between February 2003 and April 2017 were retrospectively analyzed. The study included patients with compatible clinical findings in whom PcP was confirmed via direct immunofluorescence assay. The annual average number of cases increased from 12.2 (initial 5-year period) to 42.2 (recent 5-year period). In HIV-negative patients, hematologic malignancy (34.8{\%}) and solid organ transplantation (32.9{\%}) were the most frequent major underlying conditions, and immunosuppressive therapies including corticosteroids (342/362, 94.5{\%}) and chemotherapy (122/362, 33.7{\%}) were significantly associated with PcP infection (p < 0.001 for both). The incidence of PcP has continued to increase among non-HIV-infected immunocompromised patients in recent years.",
author = "Lee, {Hye Young} and Choi, {Sang Ho} and Tark Kim and Jeonghyun Chang and Kim, {Sung Han} and Lee, {Sang Oh} and Kim, {Mi Na} and Heungsup Sung",
year = "2019",
month = "1",
day = "1",
doi = "10.7883/yoken.JJID.2018.400",
language = "English",
volume = "72",
pages = "270--273",
journal = "Japanese Journal of Infectious Diseases",
issn = "1344-6304",
publisher = "National Institute of Health",
number = "4",

}

Epidemiologic trends and clinical features of pneumocystis jirovecii pneumonia in non-HIV patients in a tertiary-care hospital in Korea over a 15-year-period. / Lee, Hye Young; Choi, Sang Ho; Kim, Tark; Chang, Jeonghyun; Kim, Sung Han; Lee, Sang Oh; Kim, Mi Na; Sung, Heungsup.

In: Japanese journal of infectious diseases, Vol. 72, No. 4, 01.01.2019, p. 270-273.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Epidemiologic trends and clinical features of pneumocystis jirovecii pneumonia in non-HIV patients in a tertiary-care hospital in Korea over a 15-year-period

AU - Lee, Hye Young

AU - Choi, Sang Ho

AU - Kim, Tark

AU - Chang, Jeonghyun

AU - Kim, Sung Han

AU - Lee, Sang Oh

AU - Kim, Mi Na

AU - Sung, Heungsup

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Subsequent to the increasing use of immunosuppressant therapy, Pneumocystis jirovecii pneumonia (PcP) has emerged as a life-threatening condition in human immunodeficiency virus (HIV)- negative patients. We investigated changes in epidemiological and clinical characteristics among PcP cases with and without HIV infections. Data of 424 patients diagnosed with PcP in a 2,700-bed Korean tertiary care hospital between February 2003 and April 2017 were retrospectively analyzed. The study included patients with compatible clinical findings in whom PcP was confirmed via direct immunofluorescence assay. The annual average number of cases increased from 12.2 (initial 5-year period) to 42.2 (recent 5-year period). In HIV-negative patients, hematologic malignancy (34.8%) and solid organ transplantation (32.9%) were the most frequent major underlying conditions, and immunosuppressive therapies including corticosteroids (342/362, 94.5%) and chemotherapy (122/362, 33.7%) were significantly associated with PcP infection (p < 0.001 for both). The incidence of PcP has continued to increase among non-HIV-infected immunocompromised patients in recent years.

AB - Subsequent to the increasing use of immunosuppressant therapy, Pneumocystis jirovecii pneumonia (PcP) has emerged as a life-threatening condition in human immunodeficiency virus (HIV)- negative patients. We investigated changes in epidemiological and clinical characteristics among PcP cases with and without HIV infections. Data of 424 patients diagnosed with PcP in a 2,700-bed Korean tertiary care hospital between February 2003 and April 2017 were retrospectively analyzed. The study included patients with compatible clinical findings in whom PcP was confirmed via direct immunofluorescence assay. The annual average number of cases increased from 12.2 (initial 5-year period) to 42.2 (recent 5-year period). In HIV-negative patients, hematologic malignancy (34.8%) and solid organ transplantation (32.9%) were the most frequent major underlying conditions, and immunosuppressive therapies including corticosteroids (342/362, 94.5%) and chemotherapy (122/362, 33.7%) were significantly associated with PcP infection (p < 0.001 for both). The incidence of PcP has continued to increase among non-HIV-infected immunocompromised patients in recent years.

UR - http://www.scopus.com/inward/record.url?scp=85071348435&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071348435&partnerID=8YFLogxK

U2 - 10.7883/yoken.JJID.2018.400

DO - 10.7883/yoken.JJID.2018.400

M3 - Article

C2 - 30918147

AN - SCOPUS:85071348435

VL - 72

SP - 270

EP - 273

JO - Japanese Journal of Infectious Diseases

JF - Japanese Journal of Infectious Diseases

SN - 1344-6304

IS - 4

ER -