Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: A prospective observational study in 12 university hospitals in Korea

Dae Won Park, Byung Chul Chunx, June Myung Kim, Jang Wook Sohn, Kyong Ran Peck, Yang Soo Kim, Young Hwa Choi, Jun Yong Choi, Sang Il Kim, Joong Sik Eom, Hyo Youl Kim, Joon Young Song, Young Goo Song, Hee Jung Choi, Min Ja Kim

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Abstract

A prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis and septic shock. Subjects included 1,192 adult patients admitted to the 22 participating intensive care units (ICUs) of 12 university hospitals in the Korean Sepsis Registry System from April, 2005 through February, 2009. Male accounted for 656 (55%) patients. Mean age was 65.0 ± 14.2 yr. Septic shock developed in 740 (62.1%) patients. Bacteremia was present in 422 (35.4%) patients. The 28-day and in-hospital mortality rates were 23.0% and 28.0%, respectively. Men were more likely to have comorbid illnesses and acute organ dysfunctions, and had higher mortality and clinical severity compared to women. While respiratory sources of sepsis were common in men, urinary sources were predominant in women. In the multivariate logistic regression analysis, cancer (odds ratio 1.89; 95% confidence interval 1.13-3.17), urinary tract infection (0.25; 0.13-0.46), APACHE II score (1.05; 1.02-1.09), SOFA score on day 1 (1.13; 1.06-1.21) and metabolic dysfunction (2.24, 1.45-3.45) were independent clinical factors for gender-related in-hospital mortality. This study provided epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock in ICUs in Korea, and demonstrated the impact of clinical factors on gender difference in mortality.

Original languageEnglish
Pages (from-to)1308-1314
Number of pages7
JournalJournal of Korean medical science
Volume27
Issue number11
DOIs
Publication statusPublished - 2012 Dec 1

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Korea
Septic Shock
Observational Studies
Sepsis
Prospective Studies
Hospital Mortality
Intensive Care Units
Mortality
APACHE
Bacteremia
Urinary Tract Infections
Multicenter Studies
Registries
Epidemiologic Studies
Epidemiology
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, Dae Won ; Chunx, Byung Chul ; Kim, June Myung ; Sohn, Jang Wook ; Peck, Kyong Ran ; Kim, Yang Soo ; Choi, Young Hwa ; Choi, Jun Yong ; Kim, Sang Il ; Eom, Joong Sik ; Kim, Hyo Youl ; Song, Joon Young ; Song, Young Goo ; Choi, Hee Jung ; Kim, Min Ja. / Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock : A prospective observational study in 12 university hospitals in Korea. In: Journal of Korean medical science. 2012 ; Vol. 27, No. 11. pp. 1308-1314.
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title = "Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: A prospective observational study in 12 university hospitals in Korea",
abstract = "A prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis and septic shock. Subjects included 1,192 adult patients admitted to the 22 participating intensive care units (ICUs) of 12 university hospitals in the Korean Sepsis Registry System from April, 2005 through February, 2009. Male accounted for 656 (55{\%}) patients. Mean age was 65.0 ± 14.2 yr. Septic shock developed in 740 (62.1{\%}) patients. Bacteremia was present in 422 (35.4{\%}) patients. The 28-day and in-hospital mortality rates were 23.0{\%} and 28.0{\%}, respectively. Men were more likely to have comorbid illnesses and acute organ dysfunctions, and had higher mortality and clinical severity compared to women. While respiratory sources of sepsis were common in men, urinary sources were predominant in women. In the multivariate logistic regression analysis, cancer (odds ratio 1.89; 95{\%} confidence interval 1.13-3.17), urinary tract infection (0.25; 0.13-0.46), APACHE II score (1.05; 1.02-1.09), SOFA score on day 1 (1.13; 1.06-1.21) and metabolic dysfunction (2.24, 1.45-3.45) were independent clinical factors for gender-related in-hospital mortality. This study provided epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock in ICUs in Korea, and demonstrated the impact of clinical factors on gender difference in mortality.",
author = "Park, {Dae Won} and Chunx, {Byung Chul} and Kim, {June Myung} and Sohn, {Jang Wook} and Peck, {Kyong Ran} and Kim, {Yang Soo} and Choi, {Young Hwa} and Choi, {Jun Yong} and Kim, {Sang Il} and Eom, {Joong Sik} and Kim, {Hyo Youl} and Song, {Joon Young} and Song, {Young Goo} and Choi, {Hee Jung} and Kim, {Min Ja}",
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Park, DW, Chunx, BC, Kim, JM, Sohn, JW, Peck, KR, Kim, YS, Choi, YH, Choi, JY, Kim, SI, Eom, JS, Kim, HY, Song, JY, Song, YG, Choi, HJ & Kim, MJ 2012, 'Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: A prospective observational study in 12 university hospitals in Korea', Journal of Korean medical science, vol. 27, no. 11, pp. 1308-1314. https://doi.org/10.3346/jkms.2012.27.11.1308

Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock : A prospective observational study in 12 university hospitals in Korea. / Park, Dae Won; Chunx, Byung Chul; Kim, June Myung; Sohn, Jang Wook; Peck, Kyong Ran; Kim, Yang Soo; Choi, Young Hwa; Choi, Jun Yong; Kim, Sang Il; Eom, Joong Sik; Kim, Hyo Youl; Song, Joon Young; Song, Young Goo; Choi, Hee Jung; Kim, Min Ja.

In: Journal of Korean medical science, Vol. 27, No. 11, 01.12.2012, p. 1308-1314.

Research output: Contribution to journalArticle

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T1 - Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock

T2 - A prospective observational study in 12 university hospitals in Korea

AU - Park, Dae Won

AU - Chunx, Byung Chul

AU - Kim, June Myung

AU - Sohn, Jang Wook

AU - Peck, Kyong Ran

AU - Kim, Yang Soo

AU - Choi, Young Hwa

AU - Choi, Jun Yong

AU - Kim, Sang Il

AU - Eom, Joong Sik

AU - Kim, Hyo Youl

AU - Song, Joon Young

AU - Song, Young Goo

AU - Choi, Hee Jung

AU - Kim, Min Ja

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N2 - A prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis and septic shock. Subjects included 1,192 adult patients admitted to the 22 participating intensive care units (ICUs) of 12 university hospitals in the Korean Sepsis Registry System from April, 2005 through February, 2009. Male accounted for 656 (55%) patients. Mean age was 65.0 ± 14.2 yr. Septic shock developed in 740 (62.1%) patients. Bacteremia was present in 422 (35.4%) patients. The 28-day and in-hospital mortality rates were 23.0% and 28.0%, respectively. Men were more likely to have comorbid illnesses and acute organ dysfunctions, and had higher mortality and clinical severity compared to women. While respiratory sources of sepsis were common in men, urinary sources were predominant in women. In the multivariate logistic regression analysis, cancer (odds ratio 1.89; 95% confidence interval 1.13-3.17), urinary tract infection (0.25; 0.13-0.46), APACHE II score (1.05; 1.02-1.09), SOFA score on day 1 (1.13; 1.06-1.21) and metabolic dysfunction (2.24, 1.45-3.45) were independent clinical factors for gender-related in-hospital mortality. This study provided epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock in ICUs in Korea, and demonstrated the impact of clinical factors on gender difference in mortality.

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