Epidemiology and characteristics of metallo-ß-lactamase-producing Pseudomonas aeruginosa

Duck Jin Hong, Il Kwon Bae, In Ho Jang, Seok Hoon Jeong, Hyun Kyung Kang, Kyungwon Lee

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Metallo-ß-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important nosocomial pathogen that shows resistance to all ß-lactam antibiotics except monobactams. There are various types of metallo-ß-lactamases (MBLs) in carbapenem-resistant P. aeruginosa including Imipenemase (IMP), Verona integron-encoded metallo-ß-lactamase (VIM), Sao Paulo metallo-ß-lactamase (SPM), Germany imipenemase (GIM), New Delhi metallo-ß-lactamase (NDM), Florence imipenemase (FIM). Each MBL gene is located on specific genetic elements including integrons, transposons, plasmids, or on the chromosome, in which they carry genes encoding determinants of resistance to carbapenems and other antibiotics, conferring multidrug resistance to P. aeruginosa. In addition, these genetic elements are transferable to other Gram-negative species, increasing the antimicrobial resistance rate and complicating the treatment of infected patients. Therefore, it is essential to understand the epidemiology, resistance mechanism, and molecular characteristics of MPPA for infection control and prevention of a possible global health crisis. Here, we highlight the characteristics of MPPA.

Original languageEnglish
Pages (from-to)81-97
Number of pages17
JournalInfection and Chemotherapy
Volume47
Issue number2
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Pharmacology (medical)

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