Epidemiology of hepatocellular carcinoma in Japan and Korea

Soo Ryang Kim, Masatoshi Kudo, Okio Hino, Kwang Hyub Han, Young Hwa Chung, Hyo Suk Lee

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The worldwide burden of liver cancer has been estimated at 671,000 new cases for the year 2005. Hepatocellular carcinoma (HCC) accounts for between 85 and 90% of primary liver cancer and is one of the most frequent malignancies in Asia. In both Japan and Korea, the incidence exceeds 25 cases/100,000/year and ranks third in cancer deaths after stomach and lung cancer. In Korea the number of deaths from liver cancer increased from approximately 5,789 in 1983 to 9,966 in 1994, and then remained steady at 9,500/100,000 in 2003. In Japan the number of deaths from HCC increased until 2002, and then decreased to 34,089 in 2003, up to 15% of HCC cases are caused by hepatitis B virus (HBV) and ∼80% by hepatitis C virus (HCV) infection; the corresponding figures in Korea are ∼70 and ∼20%. Recent clinical data have shown that interferon and lamivudine treatment is effective in preventing the occurrence of HCC attributed to HCV and HBV infection, respectively, and that an aggressive vaccination program against the latter reduces the incidence of HCC. With the enormous efforts of researchers devoted to basic and clinical studies, the incidence of HCC is expected, in the near future, to gradually decline in both countries.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalOncology
Volume75
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2008 Dec 1

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Korea
Hepatocellular Carcinoma
Japan
Epidemiology
Liver Neoplasms
Virus Diseases
Hepatitis B virus
Hepacivirus
Incidence
Lamivudine
Interferons
Stomach Neoplasms
Lung Neoplasms
Neoplasms
Vaccination
Research Personnel

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kim, S. R., Kudo, M., Hino, O., Han, K. H., Chung, Y. H., & Lee, H. S. (2008). Epidemiology of hepatocellular carcinoma in Japan and Korea. Oncology, 75(SUPPL. 1), 13-16. https://doi.org/10.1159/000173419
Kim, Soo Ryang ; Kudo, Masatoshi ; Hino, Okio ; Han, Kwang Hyub ; Chung, Young Hwa ; Lee, Hyo Suk. / Epidemiology of hepatocellular carcinoma in Japan and Korea. In: Oncology. 2008 ; Vol. 75, No. SUPPL. 1. pp. 13-16.
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Kim, SR, Kudo, M, Hino, O, Han, KH, Chung, YH & Lee, HS 2008, 'Epidemiology of hepatocellular carcinoma in Japan and Korea', Oncology, vol. 75, no. SUPPL. 1, pp. 13-16. https://doi.org/10.1159/000173419

Epidemiology of hepatocellular carcinoma in Japan and Korea. / Kim, Soo Ryang; Kudo, Masatoshi; Hino, Okio; Han, Kwang Hyub; Chung, Young Hwa; Lee, Hyo Suk.

In: Oncology, Vol. 75, No. SUPPL. 1, 01.12.2008, p. 13-16.

Research output: Contribution to journalArticle

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Kim SR, Kudo M, Hino O, Han KH, Chung YH, Lee HS. Epidemiology of hepatocellular carcinoma in Japan and Korea. Oncology. 2008 Dec 1;75(SUPPL. 1):13-16. https://doi.org/10.1159/000173419