Epidermal hyperplasia and elevated HB-EGF are more prominent in retinoid dermatitis compared with irritant contact dermatitis induced by benzalkonium chloride

Jung Eun Lee, Jae Yong Chang, Sang Eun Lee, Moon Young Kim, Jeong Seon Lee, Min Geol Lee, Soo Chan Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: 'Retinoid dermatitis' is a retinoid-induced irritant contact dermatitis (ICD). The mechanism of retinoid dermatitis may be different from that of other ICDs. However, it remains uncertain how topical retinoid induce ICD. Objective: We compared several aspects of contact dermatitis Induced by topical retinol and benzalkonium chloride (BKC) on hairless mice skin. Methods: 2% retinol or 2.5% BKC was applied to hairless mice and transepidermal water loss (TEWL), ear thickness, histologic and immunohistochemical findings were compared. We also compared mRNA expression of inflammatory cytokines, epidermal differential markers, cyclooxygenases (COXs) and heparin binding epidermal growth factor like growth factor (HBEGF). Results: Topical application of 2% retinol and 2.5% BKC Increased TEWL and ear thickness in similar intensity. Epidermal hyperplasia was more prominent in retinol treated skin. Proliferating cell nuclear antigen, involucrin and loricrin expression were higher in retinol-treated skin than in BKC-treated skin. Filaggrin, however, was more expressed in BKC-treated skin. The mRNA expression of IL-8, TNF-tf, COX-2, involucrin, loricrin and filaggrin were increased in both retinol- and BKC-treated skin in similar intensity. HB-EGF was more significantly increased in retinol-treated skin. Conclusion: Elevated HB-EGF and epidermal hyperplasia are more prominent features of retinoid dermatitis than in BKC-induced ICD.

Original languageEnglish
Pages (from-to)290-299
Number of pages10
JournalAnnals of Dermatology
Volume22
Issue number3
DOIs
Publication statusPublished - 2010 Aug 1

Fingerprint

Irritant Dermatitis
Benzalkonium Compounds
Contact Dermatitis
Retinoids
Dermatitis
Vitamin A
Hyperplasia
Skin
Hairless Mouse
Ear
Messenger RNA
Water
Proliferating Cell Nuclear Antigen
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
Heparin-binding EGF-like Growth Factor
Interleukin-8
Epidermal Growth Factor
Heparin
Intercellular Signaling Peptides and Proteins

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

@article{68dd51e3362640c7ba0026f3ffb3fb13,
title = "Epidermal hyperplasia and elevated HB-EGF are more prominent in retinoid dermatitis compared with irritant contact dermatitis induced by benzalkonium chloride",
abstract = "Background: 'Retinoid dermatitis' is a retinoid-induced irritant contact dermatitis (ICD). The mechanism of retinoid dermatitis may be different from that of other ICDs. However, it remains uncertain how topical retinoid induce ICD. Objective: We compared several aspects of contact dermatitis Induced by topical retinol and benzalkonium chloride (BKC) on hairless mice skin. Methods: 2{\%} retinol or 2.5{\%} BKC was applied to hairless mice and transepidermal water loss (TEWL), ear thickness, histologic and immunohistochemical findings were compared. We also compared mRNA expression of inflammatory cytokines, epidermal differential markers, cyclooxygenases (COXs) and heparin binding epidermal growth factor like growth factor (HBEGF). Results: Topical application of 2{\%} retinol and 2.5{\%} BKC Increased TEWL and ear thickness in similar intensity. Epidermal hyperplasia was more prominent in retinol treated skin. Proliferating cell nuclear antigen, involucrin and loricrin expression were higher in retinol-treated skin than in BKC-treated skin. Filaggrin, however, was more expressed in BKC-treated skin. The mRNA expression of IL-8, TNF-tf, COX-2, involucrin, loricrin and filaggrin were increased in both retinol- and BKC-treated skin in similar intensity. HB-EGF was more significantly increased in retinol-treated skin. Conclusion: Elevated HB-EGF and epidermal hyperplasia are more prominent features of retinoid dermatitis than in BKC-induced ICD.",
author = "Lee, {Jung Eun} and Chang, {Jae Yong} and Lee, {Sang Eun} and Kim, {Moon Young} and Lee, {Jeong Seon} and Lee, {Min Geol} and Kim, {Soo Chan}",
year = "2010",
month = "8",
day = "1",
doi = "10.5021/ad.2010.22.3.290",
language = "English",
volume = "22",
pages = "290--299",
journal = "Annals of Dermatology",
issn = "1013-9087",
publisher = "Korean Dermatological Association",
number = "3",

}

Epidermal hyperplasia and elevated HB-EGF are more prominent in retinoid dermatitis compared with irritant contact dermatitis induced by benzalkonium chloride. / Lee, Jung Eun; Chang, Jae Yong; Lee, Sang Eun; Kim, Moon Young; Lee, Jeong Seon; Lee, Min Geol; Kim, Soo Chan.

In: Annals of Dermatology, Vol. 22, No. 3, 01.08.2010, p. 290-299.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Epidermal hyperplasia and elevated HB-EGF are more prominent in retinoid dermatitis compared with irritant contact dermatitis induced by benzalkonium chloride

AU - Lee, Jung Eun

AU - Chang, Jae Yong

AU - Lee, Sang Eun

AU - Kim, Moon Young

AU - Lee, Jeong Seon

AU - Lee, Min Geol

AU - Kim, Soo Chan

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Background: 'Retinoid dermatitis' is a retinoid-induced irritant contact dermatitis (ICD). The mechanism of retinoid dermatitis may be different from that of other ICDs. However, it remains uncertain how topical retinoid induce ICD. Objective: We compared several aspects of contact dermatitis Induced by topical retinol and benzalkonium chloride (BKC) on hairless mice skin. Methods: 2% retinol or 2.5% BKC was applied to hairless mice and transepidermal water loss (TEWL), ear thickness, histologic and immunohistochemical findings were compared. We also compared mRNA expression of inflammatory cytokines, epidermal differential markers, cyclooxygenases (COXs) and heparin binding epidermal growth factor like growth factor (HBEGF). Results: Topical application of 2% retinol and 2.5% BKC Increased TEWL and ear thickness in similar intensity. Epidermal hyperplasia was more prominent in retinol treated skin. Proliferating cell nuclear antigen, involucrin and loricrin expression were higher in retinol-treated skin than in BKC-treated skin. Filaggrin, however, was more expressed in BKC-treated skin. The mRNA expression of IL-8, TNF-tf, COX-2, involucrin, loricrin and filaggrin were increased in both retinol- and BKC-treated skin in similar intensity. HB-EGF was more significantly increased in retinol-treated skin. Conclusion: Elevated HB-EGF and epidermal hyperplasia are more prominent features of retinoid dermatitis than in BKC-induced ICD.

AB - Background: 'Retinoid dermatitis' is a retinoid-induced irritant contact dermatitis (ICD). The mechanism of retinoid dermatitis may be different from that of other ICDs. However, it remains uncertain how topical retinoid induce ICD. Objective: We compared several aspects of contact dermatitis Induced by topical retinol and benzalkonium chloride (BKC) on hairless mice skin. Methods: 2% retinol or 2.5% BKC was applied to hairless mice and transepidermal water loss (TEWL), ear thickness, histologic and immunohistochemical findings were compared. We also compared mRNA expression of inflammatory cytokines, epidermal differential markers, cyclooxygenases (COXs) and heparin binding epidermal growth factor like growth factor (HBEGF). Results: Topical application of 2% retinol and 2.5% BKC Increased TEWL and ear thickness in similar intensity. Epidermal hyperplasia was more prominent in retinol treated skin. Proliferating cell nuclear antigen, involucrin and loricrin expression were higher in retinol-treated skin than in BKC-treated skin. Filaggrin, however, was more expressed in BKC-treated skin. The mRNA expression of IL-8, TNF-tf, COX-2, involucrin, loricrin and filaggrin were increased in both retinol- and BKC-treated skin in similar intensity. HB-EGF was more significantly increased in retinol-treated skin. Conclusion: Elevated HB-EGF and epidermal hyperplasia are more prominent features of retinoid dermatitis than in BKC-induced ICD.

UR - http://www.scopus.com/inward/record.url?scp=77957920202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957920202&partnerID=8YFLogxK

U2 - 10.5021/ad.2010.22.3.290

DO - 10.5021/ad.2010.22.3.290

M3 - Article

C2 - 20711265

AN - SCOPUS:77957920202

VL - 22

SP - 290

EP - 299

JO - Annals of Dermatology

JF - Annals of Dermatology

SN - 1013-9087

IS - 3

ER -