Epidural Electrotherapy for Epilepsy

Sung Won Park, Jejung Kim, Minpyo Kang, Wonho Lee, Byong Seo Park, Hansung Kim, Se Young Choi, Sungchil Yang, Jong Hyun Ahn, Sunggu Yang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Penetrating electronics have been used for treating epilepsy, yet their therapeutic effects are debated largely due to the lack of a large-scale, real-time, and safe recording/stimulation. Here, the proposed technology integrates ultrathin epidural electronics into an electrocorticography array, therein simultaneously sampling brain signals in a large area for diagnostic purposes and delivering electrical pulses for treatment. The system is empirically tested to record the ictal-like activities of the thalamocortical network in vitro and in vivo using the epidural electronics. Also, it is newly demonstrated that the electronics selectively diminish epileptiform activities, but not normal signal transduction, in live animals. It is proposed that this technology heralds a new generation of diagnostic and therapeutic brain–machine interfaces. Such an electronic system can be applicable for several brain diseases such as tinnitus, Parkinson's disease, Huntington's disease, depression, and schizophrenia.

Original languageEnglish
Article number1801732
JournalSmall
Volume14
Issue number30
DOIs
Publication statusPublished - 2018 Jul 26

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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  • Cite this

    Park, S. W., Kim, J., Kang, M., Lee, W., Park, B. S., Kim, H., Choi, S. Y., Yang, S., Ahn, J. H., & Yang, S. (2018). Epidural Electrotherapy for Epilepsy. Small, 14(30), [1801732]. https://doi.org/10.1002/smll.201801732