Abstract
Objective: After spinal cord injury (SCI), functional and structural reorganization occurs at multiple levels of brain including motor cortex. However, the underlying mechanism still remains unclear. The current study was performed to investigate the alterations in the expression of the main regulators of neuronal development, survival and death, in the brain following thoracic contusive SCI in a mouse model. Methods: Eight-week-old female imprinting control region mice (n=60; 30-35 g) were used in this study. We analyzed the expression levels of regulators such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and histone deacetylase (HDAC) 1 in the brain following thoracic contusive SCI. Results: The expression of BDNF levels were elevated significantly compared with control group at 2 weeks after injury (p<0.05). The expression of NGF levels were elevated at 2, 4 weeks compared with control group, but these difference were not significant (p>0.05). The GDNF levels were elevated at 2 week compared with control group, but these differences were not significant (p>0.05). The difference of HDAC1 levels were not significant at 2, 4 and 8 weeks compared with control group (p>0.05). Conclusion: These results demonstrate that the upregulation of BDNF may play on important role in brain reorganization after SCI.
| Original language | English |
|---|---|
| Pages (from-to) | 337-341 |
| Number of pages | 5 |
| Journal | Journal of Korean Neurosurgical Society |
| Volume | 53 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2013 Aug 30 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Neuroscience(all)
- Clinical Neurology
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Epigenetic regulation in the brain after spinal cord injury : A comparative study. / Park, Bit Na Ri; Kim, Seok Won; Cho, Sung Rae; Lee, Ji Yong; Lee, Young Hee; Kim, Sung Hoon.
In: Journal of Korean Neurosurgical Society, Vol. 53, No. 6, 30.08.2013, p. 337-341.Research output: Contribution to journal › Article
TY - JOUR
T1 - Epigenetic regulation in the brain after spinal cord injury
T2 - A comparative study
AU - Park, Bit Na Ri
AU - Kim, Seok Won
AU - Cho, Sung Rae
AU - Lee, Ji Yong
AU - Lee, Young Hee
AU - Kim, Sung Hoon
PY - 2013/8/30
Y1 - 2013/8/30
N2 - Objective: After spinal cord injury (SCI), functional and structural reorganization occurs at multiple levels of brain including motor cortex. However, the underlying mechanism still remains unclear. The current study was performed to investigate the alterations in the expression of the main regulators of neuronal development, survival and death, in the brain following thoracic contusive SCI in a mouse model. Methods: Eight-week-old female imprinting control region mice (n=60; 30-35 g) were used in this study. We analyzed the expression levels of regulators such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and histone deacetylase (HDAC) 1 in the brain following thoracic contusive SCI. Results: The expression of BDNF levels were elevated significantly compared with control group at 2 weeks after injury (p<0.05). The expression of NGF levels were elevated at 2, 4 weeks compared with control group, but these difference were not significant (p>0.05). The GDNF levels were elevated at 2 week compared with control group, but these differences were not significant (p>0.05). The difference of HDAC1 levels were not significant at 2, 4 and 8 weeks compared with control group (p>0.05). Conclusion: These results demonstrate that the upregulation of BDNF may play on important role in brain reorganization after SCI.
AB - Objective: After spinal cord injury (SCI), functional and structural reorganization occurs at multiple levels of brain including motor cortex. However, the underlying mechanism still remains unclear. The current study was performed to investigate the alterations in the expression of the main regulators of neuronal development, survival and death, in the brain following thoracic contusive SCI in a mouse model. Methods: Eight-week-old female imprinting control region mice (n=60; 30-35 g) were used in this study. We analyzed the expression levels of regulators such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and histone deacetylase (HDAC) 1 in the brain following thoracic contusive SCI. Results: The expression of BDNF levels were elevated significantly compared with control group at 2 weeks after injury (p<0.05). The expression of NGF levels were elevated at 2, 4 weeks compared with control group, but these difference were not significant (p>0.05). The GDNF levels were elevated at 2 week compared with control group, but these differences were not significant (p>0.05). The difference of HDAC1 levels were not significant at 2, 4 and 8 weeks compared with control group (p>0.05). Conclusion: These results demonstrate that the upregulation of BDNF may play on important role in brain reorganization after SCI.
UR - http://www.scopus.com/inward/record.url?scp=84882968429&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882968429&partnerID=8YFLogxK
U2 - 10.3340/jkns.2013.53.6.337
DO - 10.3340/jkns.2013.53.6.337
M3 - Article
C2 - 24003367
AN - SCOPUS:84882968429
VL - 53
SP - 337
EP - 341
JO - Journal of Korean Neurosurgical Society
JF - Journal of Korean Neurosurgical Society
SN - 2005-3711
IS - 6
ER -