Epigenetic regulation in the brain after spinal cord injury: A comparative study

Bit Na Ri Park, Seok Won Kim, Sung Rae Cho, Ji Yong Lee, Young Hee Lee, Sung Hoon Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: After spinal cord injury (SCI), functional and structural reorganization occurs at multiple levels of brain including motor cortex. However, the underlying mechanism still remains unclear. The current study was performed to investigate the alterations in the expression of the main regulators of neuronal development, survival and death, in the brain following thoracic contusive SCI in a mouse model. Methods: Eight-week-old female imprinting control region mice (n=60; 30-35 g) were used in this study. We analyzed the expression levels of regulators such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and histone deacetylase (HDAC) 1 in the brain following thoracic contusive SCI. Results: The expression of BDNF levels were elevated significantly compared with control group at 2 weeks after injury (p<0.05). The expression of NGF levels were elevated at 2, 4 weeks compared with control group, but these difference were not significant (p>0.05). The GDNF levels were elevated at 2 week compared with control group, but these differences were not significant (p>0.05). The difference of HDAC1 levels were not significant at 2, 4 and 8 weeks compared with control group (p>0.05). Conclusion: These results demonstrate that the upregulation of BDNF may play on important role in brain reorganization after SCI.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalJournal of Korean Neurosurgical Society
Volume53
Issue number6
DOIs
Publication statusPublished - 2013 Aug 30

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Spinal Cord Injuries
Epigenomics
Brain-Derived Neurotrophic Factor
Glial Cell Line-Derived Neurotrophic Factor
Brain
Control Groups
Thorax
Histone Deacetylase 1
Brain Death
Motor Cortex
Nerve Growth Factor
Up-Regulation
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neuroscience(all)
  • Clinical Neurology

Cite this

Park, Bit Na Ri ; Kim, Seok Won ; Cho, Sung Rae ; Lee, Ji Yong ; Lee, Young Hee ; Kim, Sung Hoon. / Epigenetic regulation in the brain after spinal cord injury : A comparative study. In: Journal of Korean Neurosurgical Society. 2013 ; Vol. 53, No. 6. pp. 337-341.
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Epigenetic regulation in the brain after spinal cord injury : A comparative study. / Park, Bit Na Ri; Kim, Seok Won; Cho, Sung Rae; Lee, Ji Yong; Lee, Young Hee; Kim, Sung Hoon.

In: Journal of Korean Neurosurgical Society, Vol. 53, No. 6, 30.08.2013, p. 337-341.

Research output: Contribution to journalArticle

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