Abstract
Breast core needle biopsy (BCNB) has been reported to cause mechanical epithelial displacement into adjacent tissues, leading to diagnostic difficulties. However, epithelial displacement into lymphovascular spaces (EDLS), mimicking true lymphovascular invasion, may also be seen in the initial BCNB specimen itself. We retrospectively reviewed 218 BCNB specimens diagnosed as ductal carcinoma in situ (DCIS) and searched for the presence of EDLS. The subsequent surgically resected specimens for all cases were also reviewed. EDLS was demonstrated in 7 (3.2%) of 218 initial BCNB specimens. It could be differentiated from detached clusters of DCIS cells within preexisting ducts by morphologic features and immunohistochemical stains for D2-40 and p63. EDLS can occur at initial BCNB, and, therefore, the presence of tumor cell clusters within lymphovascular spaces in a BCNB specimen with DCIS may not represent true lymphovascular invasion.
| Original language | English |
|---|---|
| Pages (from-to) | 781-787 |
| Number of pages | 7 |
| Journal | American Journal of Clinical Pathology |
| Volume | 133 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2010 May 1 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
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Epithelial displacement into the lymphovascular space can be seen in breast core needle biopsy specimens. / Koo, Ja Seung; Jung, Woo Hee; Kim, Haeryoung.
In: American Journal of Clinical Pathology, Vol. 133, No. 5, 01.05.2010, p. 781-787.Research output: Contribution to journal › Article
TY - JOUR
T1 - Epithelial displacement into the lymphovascular space can be seen in breast core needle biopsy specimens
AU - Koo, Ja Seung
AU - Jung, Woo Hee
AU - Kim, Haeryoung
PY - 2010/5/1
Y1 - 2010/5/1
N2 - Breast core needle biopsy (BCNB) has been reported to cause mechanical epithelial displacement into adjacent tissues, leading to diagnostic difficulties. However, epithelial displacement into lymphovascular spaces (EDLS), mimicking true lymphovascular invasion, may also be seen in the initial BCNB specimen itself. We retrospectively reviewed 218 BCNB specimens diagnosed as ductal carcinoma in situ (DCIS) and searched for the presence of EDLS. The subsequent surgically resected specimens for all cases were also reviewed. EDLS was demonstrated in 7 (3.2%) of 218 initial BCNB specimens. It could be differentiated from detached clusters of DCIS cells within preexisting ducts by morphologic features and immunohistochemical stains for D2-40 and p63. EDLS can occur at initial BCNB, and, therefore, the presence of tumor cell clusters within lymphovascular spaces in a BCNB specimen with DCIS may not represent true lymphovascular invasion.
AB - Breast core needle biopsy (BCNB) has been reported to cause mechanical epithelial displacement into adjacent tissues, leading to diagnostic difficulties. However, epithelial displacement into lymphovascular spaces (EDLS), mimicking true lymphovascular invasion, may also be seen in the initial BCNB specimen itself. We retrospectively reviewed 218 BCNB specimens diagnosed as ductal carcinoma in situ (DCIS) and searched for the presence of EDLS. The subsequent surgically resected specimens for all cases were also reviewed. EDLS was demonstrated in 7 (3.2%) of 218 initial BCNB specimens. It could be differentiated from detached clusters of DCIS cells within preexisting ducts by morphologic features and immunohistochemical stains for D2-40 and p63. EDLS can occur at initial BCNB, and, therefore, the presence of tumor cell clusters within lymphovascular spaces in a BCNB specimen with DCIS may not represent true lymphovascular invasion.
UR - http://www.scopus.com/inward/record.url?scp=77951935272&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951935272&partnerID=8YFLogxK
U2 - 10.1309/AJCPQ0LEIOUTMSUD
DO - 10.1309/AJCPQ0LEIOUTMSUD
M3 - Article
C2 - 20395526
AN - SCOPUS:77951935272
VL - 133
SP - 781
EP - 787
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 5
ER -