Epithelial plasticity enhances regeneration of committed taste receptor cells following nerve injury

Anish Ashok Adpaikar, Jong Min Lee, Dong Joon Lee, Hye Yeon Cho, Hayato Ohshima, Seok Jun Moon, Han Sung Jung

Research output: Contribution to journalArticlepeer-review


Taste receptor cells are taste bud epithelial cells that are dependent upon the innervating nerve for continuous renewal and are maintained by resident tissue stem/progenitor cells. Transection of the innervating nerve causes degeneration of taste buds and taste receptor cells. However, a subset of the taste receptor cells is maintained without nerve contact after glossopharyngeal nerve transection in the circumvallate papilla in adult mice. Here, we revealed that injury caused by glossopharyngeal nerve transection triggers the remaining differentiated K8-positive taste receptor cells to dedifferentiate and acquire transient progenitor cell-like states during regeneration. Dedifferentiated taste receptor cells proliferate, express progenitor cell markers (K14, Sox2, PCNA) and form organoids in vitro. These data indicate that differentiated taste receptor cells can enter the cell cycle, acquire stemness, and participate in taste bud regeneration. We propose that dedifferentiated taste receptor cells in combination with stem/progenitor cells enhance the regeneration of taste buds following nerve injury.

Original languageEnglish
Pages (from-to)171-182
Number of pages12
JournalExperimental and Molecular Medicine
Issue number1
Publication statusPublished - 2023 Jan

Bibliographical note

Funding Information:
The National Research Foundation of Korea (NRF) Grant funded by the Korea Government (MSIP) (NRF‐2016R1A5A2008630, NRF-2022R1A2B5B03001627 and NRF-2021R1A2C1005506) supported this work.

Publisher Copyright:
© 2023, The Author(s).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry


Dive into the research topics of 'Epithelial plasticity enhances regeneration of committed taste receptor cells following nerve injury'. Together they form a unique fingerprint.

Cite this