Abstract
Background: Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries. Aim: To elucidate the possible association of EBVwith CD30+ anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea. Methods: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30+ ALCL involving the skin which were selected from six university hospital medical centers in South Korea. Results: In situ hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30+ ALCL and in none of the cases of LyP. One EBER-positive case was cutaneous CD30+ ALCL with concurrent lymph node involvement. The other was CD30+ ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP-1 was also positive only for the two cases of EBER-positive CD30+ ALCL. Conclusion: LyP and primary cutaneous CD30+ ALCL are very rarely associated with EBV in South Korea.
Original language | English |
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Pages (from-to) | 1312-1316 |
Number of pages | 5 |
Journal | International Journal of Dermatology |
Volume | 45 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2006 Nov |
All Science Journal Classification (ASJC) codes
- Dermatology