Epstein-Barr virus in CD30 + anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea

You Chan Kim, Woo Ick Yang, Mingeol Lee, Soo Nam Kim, Kwang Hyun Cho, Seok Jong Lee, Mi Woo Lee, Jai Kyoung Koh

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Abstract

Background: Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries. Aim: To elucidate the possible association of EBVwith CD30 + anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea. Methods: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30 + ALCL involving the skin which were selected from six university hospital medical centers in South Korea. Results: In situ hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30 + ALCL and in none of the cases of LyP. One EBER-positive case was cutaneous CD30 + ALCL with concurrent lymph node involvement. The other was CD30 + ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP-1 was also positive only for the two cases of EBER-positive CD30 + ALCL. Conclusion: LyP and primary cutaneous CD30 + ALCL are very rarely associated with EBV in South Korea.

Original languageEnglish
Pages (from-to)1312-1316
Number of pages5
JournalInternational Journal of Dermatology
Volume45
Issue number11
DOIs
Publication statusPublished - 2006 Nov 1

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Lymphomatoid Papulosis
Anaplastic Large-Cell Lymphoma
Republic of Korea
Human Herpesvirus 4
Skin
RNA
In Situ Hybridization
Primary Cutaneous Anaplastic Large Cell Lymphoma
Viral Matrix Proteins
Lymph Nodes
Lymphoproliferative Disorders
Paraffin
Formaldehyde
Membrane Proteins
Spleen
Immunohistochemistry
Bone and Bones
Lung

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Kim, You Chan ; Yang, Woo Ick ; Lee, Mingeol ; Kim, Soo Nam ; Cho, Kwang Hyun ; Lee, Seok Jong ; Lee, Mi Woo ; Koh, Jai Kyoung. / Epstein-Barr virus in CD30 + anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea In: International Journal of Dermatology. 2006 ; Vol. 45, No. 11. pp. 1312-1316.
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abstract = "Background: Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries. Aim: To elucidate the possible association of EBVwith CD30 + anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea. Methods: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30 + ALCL involving the skin which were selected from six university hospital medical centers in South Korea. Results: In situ hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30 + ALCL and in none of the cases of LyP. One EBER-positive case was cutaneous CD30 + ALCL with concurrent lymph node involvement. The other was CD30 + ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP-1 was also positive only for the two cases of EBER-positive CD30 + ALCL. Conclusion: LyP and primary cutaneous CD30 + ALCL are very rarely associated with EBV in South Korea.",
author = "Kim, {You Chan} and Yang, {Woo Ick} and Mingeol Lee and Kim, {Soo Nam} and Cho, {Kwang Hyun} and Lee, {Seok Jong} and Lee, {Mi Woo} and Koh, {Jai Kyoung}",
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Epstein-Barr virus in CD30 + anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea . / Kim, You Chan; Yang, Woo Ick; Lee, Mingeol; Kim, Soo Nam; Cho, Kwang Hyun; Lee, Seok Jong; Lee, Mi Woo; Koh, Jai Kyoung.

In: International Journal of Dermatology, Vol. 45, No. 11, 01.11.2006, p. 1312-1316.

Research output: Contribution to journalArticle

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T1 - Epstein-Barr virus in CD30 + anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea

AU - Kim, You Chan

AU - Yang, Woo Ick

AU - Lee, Mingeol

AU - Kim, Soo Nam

AU - Cho, Kwang Hyun

AU - Lee, Seok Jong

AU - Lee, Mi Woo

AU - Koh, Jai Kyoung

PY - 2006/11/1

Y1 - 2006/11/1

N2 - Background: Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries. Aim: To elucidate the possible association of EBVwith CD30 + anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea. Methods: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30 + ALCL involving the skin which were selected from six university hospital medical centers in South Korea. Results: In situ hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30 + ALCL and in none of the cases of LyP. One EBER-positive case was cutaneous CD30 + ALCL with concurrent lymph node involvement. The other was CD30 + ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP-1 was also positive only for the two cases of EBER-positive CD30 + ALCL. Conclusion: LyP and primary cutaneous CD30 + ALCL are very rarely associated with EBV in South Korea.

AB - Background: Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries. Aim: To elucidate the possible association of EBVwith CD30 + anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea. Methods: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30 + ALCL involving the skin which were selected from six university hospital medical centers in South Korea. Results: In situ hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30 + ALCL and in none of the cases of LyP. One EBER-positive case was cutaneous CD30 + ALCL with concurrent lymph node involvement. The other was CD30 + ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP-1 was also positive only for the two cases of EBER-positive CD30 + ALCL. Conclusion: LyP and primary cutaneous CD30 + ALCL are very rarely associated with EBV in South Korea.

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