Epstein-Barr virus in CD30+ anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea

You Chan Kim, Woo Ick Yang, Min Geol Lee, Soo Nam Kim, Kwang Hyun Cho, Seok Jong Lee, Mi Woo Lee, Jai Kyoung Koh

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23 Citations (Scopus)

Abstract

Background: Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries. Aim: To elucidate the possible association of EBVwith CD30+ anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea. Methods: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30+ ALCL involving the skin which were selected from six university hospital medical centers in South Korea. Results: In situ hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30+ ALCL and in none of the cases of LyP. One EBER-positive case was cutaneous CD30+ ALCL with concurrent lymph node involvement. The other was CD30+ ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP-1 was also positive only for the two cases of EBER-positive CD30+ ALCL. Conclusion: LyP and primary cutaneous CD30+ ALCL are very rarely associated with EBV in South Korea.

Original languageEnglish
Pages (from-to)1312-1316
Number of pages5
JournalInternational Journal of Dermatology
Volume45
Issue number11
DOIs
Publication statusPublished - 2006 Nov

All Science Journal Classification (ASJC) codes

  • Dermatology

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