Abstract
Background: Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries. Aim: To elucidate the possible association of EBVwith CD30+ anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea. Methods: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30+ ALCL involving the skin which were selected from six university hospital medical centers in South Korea. Results: In situ hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30+ ALCL and in none of the cases of LyP. One EBER-positive case was cutaneous CD30+ ALCL with concurrent lymph node involvement. The other was CD30+ ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP-1 was also positive only for the two cases of EBER-positive CD30+ ALCL. Conclusion: LyP and primary cutaneous CD30+ ALCL are very rarely associated with EBV in South Korea.
| Original language | English |
|---|---|
| Pages (from-to) | 1312-1316 |
| Number of pages | 5 |
| Journal | International Journal of Dermatology |
| Volume | 45 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2006 Nov 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Dermatology
Cite this
}
Epstein-Barr virus in CD30+ anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea. / Kim, You Chan; Yang, Woo Ick; Lee, Min Geol; Kim, Soo Nam; Cho, Kwang Hyun; Lee, Seok Jong; Lee, Mi Woo; Koh, Jai Kyoung.
In: International Journal of Dermatology, Vol. 45, No. 11, 01.11.2006, p. 1312-1316.Research output: Contribution to journal › Article
TY - JOUR
T1 - Epstein-Barr virus in CD30+ anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea
AU - Kim, You Chan
AU - Yang, Woo Ick
AU - Lee, Min Geol
AU - Kim, Soo Nam
AU - Cho, Kwang Hyun
AU - Lee, Seok Jong
AU - Lee, Mi Woo
AU - Koh, Jai Kyoung
PY - 2006/11/1
Y1 - 2006/11/1
N2 - Background: Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries. Aim: To elucidate the possible association of EBVwith CD30+ anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea. Methods: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30+ ALCL involving the skin which were selected from six university hospital medical centers in South Korea. Results: In situ hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30+ ALCL and in none of the cases of LyP. One EBER-positive case was cutaneous CD30+ ALCL with concurrent lymph node involvement. The other was CD30+ ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP-1 was also positive only for the two cases of EBER-positive CD30+ ALCL. Conclusion: LyP and primary cutaneous CD30+ ALCL are very rarely associated with EBV in South Korea.
AB - Background: Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries. Aim: To elucidate the possible association of EBVwith CD30+ anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea. Methods: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30+ ALCL involving the skin which were selected from six university hospital medical centers in South Korea. Results: In situ hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30+ ALCL and in none of the cases of LyP. One EBER-positive case was cutaneous CD30+ ALCL with concurrent lymph node involvement. The other was CD30+ ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP-1 was also positive only for the two cases of EBER-positive CD30+ ALCL. Conclusion: LyP and primary cutaneous CD30+ ALCL are very rarely associated with EBV in South Korea.
UR - http://www.scopus.com/inward/record.url?scp=33750628740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750628740&partnerID=8YFLogxK
U2 - 10.1111/j.1365-4632.2006.02951.x
DO - 10.1111/j.1365-4632.2006.02951.x
M3 - Article
C2 - 17076712
AN - SCOPUS:33750628740
VL - 45
SP - 1312
EP - 1316
JO - International Journal of Dermatology
JF - International Journal of Dermatology
SN - 0011-9059
IS - 11
ER -