Loss of Max function in the mouse resulted in generalized developmental arrest of both embryonic and extra-embryonic tissues at early postimplantation (~E5.5-6.5), coincident with loss or dilution of maternal Max stores in the expanding embryo in vivo and in blastocyst outgrowths in vitro. Developmentally arrested embryos were reduced in size and exhibited widespread cytological degeneration and feeble BrdU incorporation. Max and, by extension, the Myc superfamily, serve essential roles in early mammalian development and a maternal reservoir of Max exists in sufficient amount to sustain Myc superfamily function through preimplantation stages of development.
|Number of pages||6|
|Journal||Genes and Development|
|Publication status||Published - 2000 Jan 1|
All Science Journal Classification (ASJC) codes
- Developmental Biology