Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells

Xianglan Quan, Tuyet Thi Nguyen, Seong Kyung Choi, Shanhua Xu, Ranjan Das, Seungkuy Cha, Nari Kim, Jin Han, Andreas Wiederkehr, Claes B. Wollheim, Kyusang Park

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Mitochondrial Ca2+ uptake affects energy metabolism and insulin secretion. Results: Knockdown of mitochondrial Ca2+ uniporter decreases respiratory chain activity and mitochondrial pH gradient generation. Conclusion: Mitochondrial Ca2+ uptake via uniporter is essential for oxidative phosphorylation and metabolism-secretion coupling. Significance: The present study identifies mechanisms of action and bioenergetic consequences of mitochondrial Ca2+ transporters in insulin-releasing cells.

Original languageEnglish
Pages (from-to)4086-4096
Number of pages11
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
Publication statusPublished - 2015 Feb 13

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Proton-Motive Force
Metabolism
Energy Metabolism
Insulin
Oxidative Phosphorylation
Electron Transport

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Quan, Xianglan ; Nguyen, Tuyet Thi ; Choi, Seong Kyung ; Xu, Shanhua ; Das, Ranjan ; Cha, Seungkuy ; Kim, Nari ; Han, Jin ; Wiederkehr, Andreas ; Wollheim, Claes B. ; Park, Kyusang. / Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 7. pp. 4086-4096.
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Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells. / Quan, Xianglan; Nguyen, Tuyet Thi; Choi, Seong Kyung; Xu, Shanhua; Das, Ranjan; Cha, Seungkuy; Kim, Nari; Han, Jin; Wiederkehr, Andreas; Wollheim, Claes B.; Park, Kyusang.

In: Journal of Biological Chemistry, Vol. 290, No. 7, 13.02.2015, p. 4086-4096.

Research output: Contribution to journalArticle

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AU - Xu, Shanhua

AU - Das, Ranjan

AU - Cha, Seungkuy

AU - Kim, Nari

AU - Han, Jin

AU - Wiederkehr, Andreas

AU - Wollheim, Claes B.

AU - Park, Kyusang

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