Abstract
Background: Mitochondrial Ca2+ uptake affects energy metabolism and insulin secretion. Results: Knockdown of mitochondrial Ca2+ uniporter decreases respiratory chain activity and mitochondrial pH gradient generation. Conclusion: Mitochondrial Ca2+ uptake via uniporter is essential for oxidative phosphorylation and metabolism-secretion coupling. Significance: The present study identifies mechanisms of action and bioenergetic consequences of mitochondrial Ca2+ transporters in insulin-releasing cells.
| Original language | English |
|---|---|
| Pages (from-to) | 4086-4096 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 290 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2015 Feb 13 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology
Cite this
}
Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells. / Quan, Xianglan; Nguyen, Tuyet Thi; Choi, Seong Kyung; Xu, Shanhua; Das, Ranjan; Cha, Seung Kuy; Kim, Nari; Han, Jin; Wiederkehr, Andreas; Wollheim, Claes B.; Park, Kyu Sang.
In: Journal of Biological Chemistry, Vol. 290, No. 7, 13.02.2015, p. 4086-4096.Research output: Contribution to journal › Article
TY - JOUR
T1 - Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells
AU - Quan, Xianglan
AU - Nguyen, Tuyet Thi
AU - Choi, Seong Kyung
AU - Xu, Shanhua
AU - Das, Ranjan
AU - Cha, Seung Kuy
AU - Kim, Nari
AU - Han, Jin
AU - Wiederkehr, Andreas
AU - Wollheim, Claes B.
AU - Park, Kyu Sang
PY - 2015/2/13
Y1 - 2015/2/13
N2 - Background: Mitochondrial Ca2+ uptake affects energy metabolism and insulin secretion. Results: Knockdown of mitochondrial Ca2+ uniporter decreases respiratory chain activity and mitochondrial pH gradient generation. Conclusion: Mitochondrial Ca2+ uptake via uniporter is essential for oxidative phosphorylation and metabolism-secretion coupling. Significance: The present study identifies mechanisms of action and bioenergetic consequences of mitochondrial Ca2+ transporters in insulin-releasing cells.
AB - Background: Mitochondrial Ca2+ uptake affects energy metabolism and insulin secretion. Results: Knockdown of mitochondrial Ca2+ uniporter decreases respiratory chain activity and mitochondrial pH gradient generation. Conclusion: Mitochondrial Ca2+ uptake via uniporter is essential for oxidative phosphorylation and metabolism-secretion coupling. Significance: The present study identifies mechanisms of action and bioenergetic consequences of mitochondrial Ca2+ transporters in insulin-releasing cells.
UR - http://www.scopus.com/inward/record.url?scp=84922949995&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922949995&partnerID=8YFLogxK
U2 - 10.1074/jbc.M114.632547
DO - 10.1074/jbc.M114.632547
M3 - Article
C2 - 25548283
AN - SCOPUS:84922949995
VL - 290
SP - 4086
EP - 4096
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 7
ER -