Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells

Xianglan Quan, Tuyet Thi Nguyen, Seong Kyung Choi, Shanhua Xu, Ranjan Das, Seung Kuy Cha, Nari Kim, Jin Han, Andreas Wiederkehr, Claes B. Wollheim, Kyu Sang Park

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Mitochondrial Ca2+ uptake affects energy metabolism and insulin secretion. Results: Knockdown of mitochondrial Ca2+ uniporter decreases respiratory chain activity and mitochondrial pH gradient generation. Conclusion: Mitochondrial Ca2+ uptake via uniporter is essential for oxidative phosphorylation and metabolism-secretion coupling. Significance: The present study identifies mechanisms of action and bioenergetic consequences of mitochondrial Ca2+ transporters in insulin-releasing cells.

Original languageEnglish
Pages (from-to)4086-4096
Number of pages11
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
Publication statusPublished - 2015 Feb 13

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Proton-Motive Force
Metabolism
Energy Metabolism
Insulin
Oxidative Phosphorylation
Electron Transport

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Quan, Xianglan ; Nguyen, Tuyet Thi ; Choi, Seong Kyung ; Xu, Shanhua ; Das, Ranjan ; Cha, Seung Kuy ; Kim, Nari ; Han, Jin ; Wiederkehr, Andreas ; Wollheim, Claes B. ; Park, Kyu Sang. / Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 7. pp. 4086-4096.
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Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells. / Quan, Xianglan; Nguyen, Tuyet Thi; Choi, Seong Kyung; Xu, Shanhua; Das, Ranjan; Cha, Seung Kuy; Kim, Nari; Han, Jin; Wiederkehr, Andreas; Wollheim, Claes B.; Park, Kyu Sang.

In: Journal of Biological Chemistry, Vol. 290, No. 7, 13.02.2015, p. 4086-4096.

Research output: Contribution to journalArticle

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AU - Xu, Shanhua

AU - Das, Ranjan

AU - Cha, Seung Kuy

AU - Kim, Nari

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AU - Wiederkehr, Andreas

AU - Wollheim, Claes B.

AU - Park, Kyu Sang

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