Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells

Xianglan Quan, Tuyet Thi Nguyen, Seong Kyung Choi, Shanhua Xu, Ranjan Das, Seung Kuy Cha, Nari Kim, Jin Han, Andreas Wiederkehr, Claes B. Wollheim, Kyu Sang Park

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34 Citations (Scopus)

Abstract

Background: Mitochondrial Ca2+ uptake affects energy metabolism and insulin secretion. Results: Knockdown of mitochondrial Ca2+ uniporter decreases respiratory chain activity and mitochondrial pH gradient generation. Conclusion: Mitochondrial Ca2+ uptake via uniporter is essential for oxidative phosphorylation and metabolism-secretion coupling. Significance: The present study identifies mechanisms of action and bioenergetic consequences of mitochondrial Ca2+ transporters in insulin-releasing cells.

Original languageEnglish
Pages (from-to)4086-4096
Number of pages11
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
Publication statusPublished - 2015 Feb 13

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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