Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His

Jaewon Oh; Sun Ho Lee; Jungyoon Choi; Jong Rak Choi; Sangwoo Kim; Yun Ji Cha; Hyo Kyoung Choi; Dongju Won; Ho Geun Yoon; Sahng Wook Park; Seok Min Kang; Seung Tae Lee; Seung Hyun Lee

doi:10.1016/j.scr.2021.102508

Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His

Jaewon Oh, Sun Ho Lee, Jungyoon Choi, Jong Rak Choi, Sangwoo Kim, Yun Ji Cha, Hyo Kyoung Choi, Dongju Won, Ho Geun Yoon, Sahng Wook Park, Seok Min Kang, Seung Tae Lee, Seung Hyun Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Cardiac laminopathy caused by mutations in the LMNA gene are common and highly penetrant with a poor prognosis. We have generated a novel human induced pluripotent stem cell(iPSC) lines YCMi003-A from a patient with dilated cardiomyopathy associated with genetic variant LMNA c.1090G > C; p.Asp364His. We reprogrammed patient-specific peripheral blood mononuclear cells using five episomal vectors Oct4, Sox2, Lin28, L-Myc, and Klf4. The reported iPSC line would be a useful model for in vitro modeling of cardiac laminopathy.

Original language	English
Article number	102508
Journal	Stem Cell Research
Volume	56
DOIs	https://doi.org/10.1016/j.scr.2021.102508
Publication status	Published - 2021 Oct

Bibliographical note

Funding Information:
This work has supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1I1A1A01074368, 2019R1C1C1002334, 2018R1D1A1B07049956). This study also was supported by Samjung-Dalim Faculty research grant of Yonsei University College of Medicine (6-2019-0126), and a grant from the Korea Food Research Institute funded by the Ministry of Science, ICT & Future Planning (E0210400). Human stem cell line, CMC-hiPSC-011 was provided by National Stem Cell Bank of Korea (Korea National Institute of Health), originally provided from Catholic University.

Publisher Copyright:
© 2021 The Author(s)

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

Access to Document

10.1016/j.scr.2021.102508

Cite this

Oh, J., Lee, S. H., Choi, J., Choi, J. R., Kim, S., Cha, Y. J., Choi, H. K., Won, D., Yoon, H. G., Park, S. W., Kang, S. M., Lee, S. T., & Lee, S. H. (2021). Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His. Stem Cell Research, 56, [102508]. https://doi.org/10.1016/j.scr.2021.102508

@article{5965d22993f54314a5873cb44c82b647,

title = "Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His",

abstract = "Cardiac laminopathy caused by mutations in the LMNA gene are common and highly penetrant with a poor prognosis. We have generated a novel human induced pluripotent stem cell(iPSC) lines YCMi003-A from a patient with dilated cardiomyopathy associated with genetic variant LMNA c.1090G > C; p.Asp364His. We reprogrammed patient-specific peripheral blood mononuclear cells using five episomal vectors Oct4, Sox2, Lin28, L-Myc, and Klf4. The reported iPSC line would be a useful model for in vitro modeling of cardiac laminopathy.",

author = "Jaewon Oh and Lee, {Sun Ho} and Jungyoon Choi and Choi, {Jong Rak} and Sangwoo Kim and Cha, {Yun Ji} and Choi, {Hyo Kyoung} and Dongju Won and Yoon, {Ho Geun} and Park, {Sahng Wook} and Kang, {Seok Min} and Lee, {Seung Tae} and Lee, {Seung Hyun}",

note = "Funding Information: This work has supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1I1A1A01074368, 2019R1C1C1002334, 2018R1D1A1B07049956). This study also was supported by Samjung-Dalim Faculty research grant of Yonsei University College of Medicine (6-2019-0126), and a grant from the Korea Food Research Institute funded by the Ministry of Science, ICT & Future Planning (E0210400). Human stem cell line, CMC-hiPSC-011 was provided by National Stem Cell Bank of Korea (Korea National Institute of Health), originally provided from Catholic University. Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = oct,

doi = "10.1016/j.scr.2021.102508",

language = "English",

volume = "56",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

}

TY - JOUR

T1 - Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His

AU - Oh, Jaewon

AU - Lee, Sun Ho

AU - Choi, Jungyoon

AU - Choi, Jong Rak

AU - Kim, Sangwoo

AU - Cha, Yun Ji

AU - Choi, Hyo Kyoung

AU - Won, Dongju

AU - Yoon, Ho Geun

AU - Park, Sahng Wook

AU - Kang, Seok Min

AU - Lee, Seung Tae

AU - Lee, Seung Hyun

N1 - Funding Information: This work has supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1I1A1A01074368, 2019R1C1C1002334, 2018R1D1A1B07049956). This study also was supported by Samjung-Dalim Faculty research grant of Yonsei University College of Medicine (6-2019-0126), and a grant from the Korea Food Research Institute funded by the Ministry of Science, ICT & Future Planning (E0210400). Human stem cell line, CMC-hiPSC-011 was provided by National Stem Cell Bank of Korea (Korea National Institute of Health), originally provided from Catholic University. Publisher Copyright: © 2021 The Author(s)

PY - 2021/10

Y1 - 2021/10

N2 - Cardiac laminopathy caused by mutations in the LMNA gene are common and highly penetrant with a poor prognosis. We have generated a novel human induced pluripotent stem cell(iPSC) lines YCMi003-A from a patient with dilated cardiomyopathy associated with genetic variant LMNA c.1090G > C; p.Asp364His. We reprogrammed patient-specific peripheral blood mononuclear cells using five episomal vectors Oct4, Sox2, Lin28, L-Myc, and Klf4. The reported iPSC line would be a useful model for in vitro modeling of cardiac laminopathy.

AB - Cardiac laminopathy caused by mutations in the LMNA gene are common and highly penetrant with a poor prognosis. We have generated a novel human induced pluripotent stem cell(iPSC) lines YCMi003-A from a patient with dilated cardiomyopathy associated with genetic variant LMNA c.1090G > C; p.Asp364His. We reprogrammed patient-specific peripheral blood mononuclear cells using five episomal vectors Oct4, Sox2, Lin28, L-Myc, and Klf4. The reported iPSC line would be a useful model for in vitro modeling of cardiac laminopathy.

UR - http://www.scopus.com/inward/record.url?scp=85113344114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85113344114&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2021.102508

DO - 10.1016/j.scr.2021.102508

M3 - Article

C2 - 34438160

AN - SCOPUS:85113344114

SN - 1873-5061

VL - 56

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 102508

ER -

Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic variant LMNA p.Asp364His

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this