Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

Jeewoo Lee, Sang Uk Kang, Su Yeon Kim, Sung Eun Kim, Mee Kyoung Kang, Yeong Joon Jo, Sunghoon Kim

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The structure-activity relationship on a series of ester and hydroxamate analogues of methionyl and isoleucyl adenylate has been investigated through introducing linkers between the 1′-position of ribose and adenine surrogates as methionyl-tRNA, and isoleucyl-tRNA synthetase inhibitors, respectively. The results indicate that ester analogue 23 was found to be a potent inhibitor of Escherichia coli methionyl-tRNA synthetase, and its interaction with the active site was proposed by a molecular modeling study.

Original languageEnglish
Pages (from-to)961-964
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number8
DOIs
Publication statusPublished - 2001 Apr 23

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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