The structure-activity relationship on a series of ester and hydroxamate analogues of methionyl and isoleucyl adenylate has been investigated through introducing linkers between the 1′-position of ribose and adenine surrogates as methionyl-tRNA, and isoleucyl-tRNA synthetase inhibitors, respectively. The results indicate that ester analogue 23 was found to be a potent inhibitor of Escherichia coli methionyl-tRNA synthetase, and its interaction with the active site was proposed by a molecular modeling study.
Bibliographical noteFunding Information:
This work was supported in part by a grant (HMP-00-CH-15-0014) from the Ministry of Health & Welfare, R.O.K. the Brain Korea 21 Project to J. Lee, as well as a grant from the National Creative Research Initiatives to S. Kim.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry