Estimating the prevalence of treated epilepsy using administrative health data and its validity: ESSENCE study

Committee on Epidemiology of Korean Epilepsy Society

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background and Purpose Few of the epidemiologic studies of epilepsy have utilized well-validated nationwide databases. We estimated the nationwide prevalence of treated epilepsy based on a comprehensive medical payment database along with diagnostic validation. Methods We collected data on patients prescribed of antiepileptic drugs (AEDs) from the Health Insurance Review and Assessment service, which covers the entire population of Ko­rea. To assess the diagnostic validity, a medical records survey was conducted involving 6,774 patients prescribed AEDs from 43 institutions based on regional clusters and referral levels across the country. The prevalence of treated epilepsy was estimated by projecting the diag­nostic validity on the number of patients prescribed AEDs. Results The mean positive predictive value (PPV) for epilepsy was 0.810 for those prescribed AEDs with diagnostic codes that indicate epilepsy or seizure (Diagnosis-E), while it was 0.066 for those without Diagnosis-E. The PPV tended to decrease with age in both groups, with lower values seen in females. The prevalence was 3.84 per 1,000, and it was higher among males, chil­dren, and the elderly. Conclusions The prevalence of epilepsy in Korea was comparable to that in other East Asian countries. The diagnostic validity of administrative health data varies depending on the method of case ascertainment, age, and sex. The prescriptions of AEDs even without relevant diagnostic codes should be considered as a tracer for epilepsy.

Original languageEnglish
Pages (from-to)434-440
Number of pages7
JournalJournal of Clinical Neurology (Korea)
Volume12
Issue number4
DOIs
Publication statusPublished - 2016 Oct

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Epilepsy
Anticonvulsants
Health
Korea
Pharmaceutical Services Insurance
Databases
Prescription Drugs
Health Insurance
Medical Records
Epidemiologic Studies
Seizures
Referral and Consultation
Population

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Committee on Epidemiology of Korean Epilepsy Society. / Estimating the prevalence of treated epilepsy using administrative health data and its validity : ESSENCE study. In: Journal of Clinical Neurology (Korea). 2016 ; Vol. 12, No. 4. pp. 434-440.
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Estimating the prevalence of treated epilepsy using administrative health data and its validity : ESSENCE study. / Committee on Epidemiology of Korean Epilepsy Society.

In: Journal of Clinical Neurology (Korea), Vol. 12, No. 4, 10.2016, p. 434-440.

Research output: Contribution to journalArticle

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T1 - Estimating the prevalence of treated epilepsy using administrative health data and its validity

T2 - ESSENCE study

AU - Committee on Epidemiology of Korean Epilepsy Society

AU - Lee, Seo Young

AU - Chung, Soo Eun

AU - Kim, Dong Wook

AU - Eun, So Hee

AU - Kang, Hoon Chul

AU - Cho, Yong Won

AU - Yi, Sang Do

AU - Kim, Heung Dong

AU - Jung, Ki Young

AU - Cheong, Hae Kwan

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N2 - Background and Purpose Few of the epidemiologic studies of epilepsy have utilized well-validated nationwide databases. We estimated the nationwide prevalence of treated epilepsy based on a comprehensive medical payment database along with diagnostic validation. Methods We collected data on patients prescribed of antiepileptic drugs (AEDs) from the Health Insurance Review and Assessment service, which covers the entire population of Ko­rea. To assess the diagnostic validity, a medical records survey was conducted involving 6,774 patients prescribed AEDs from 43 institutions based on regional clusters and referral levels across the country. The prevalence of treated epilepsy was estimated by projecting the diag­nostic validity on the number of patients prescribed AEDs. Results The mean positive predictive value (PPV) for epilepsy was 0.810 for those prescribed AEDs with diagnostic codes that indicate epilepsy or seizure (Diagnosis-E), while it was 0.066 for those without Diagnosis-E. The PPV tended to decrease with age in both groups, with lower values seen in females. The prevalence was 3.84 per 1,000, and it was higher among males, chil­dren, and the elderly. Conclusions The prevalence of epilepsy in Korea was comparable to that in other East Asian countries. The diagnostic validity of administrative health data varies depending on the method of case ascertainment, age, and sex. The prescriptions of AEDs even without relevant diagnostic codes should be considered as a tracer for epilepsy.

AB - Background and Purpose Few of the epidemiologic studies of epilepsy have utilized well-validated nationwide databases. We estimated the nationwide prevalence of treated epilepsy based on a comprehensive medical payment database along with diagnostic validation. Methods We collected data on patients prescribed of antiepileptic drugs (AEDs) from the Health Insurance Review and Assessment service, which covers the entire population of Ko­rea. To assess the diagnostic validity, a medical records survey was conducted involving 6,774 patients prescribed AEDs from 43 institutions based on regional clusters and referral levels across the country. The prevalence of treated epilepsy was estimated by projecting the diag­nostic validity on the number of patients prescribed AEDs. Results The mean positive predictive value (PPV) for epilepsy was 0.810 for those prescribed AEDs with diagnostic codes that indicate epilepsy or seizure (Diagnosis-E), while it was 0.066 for those without Diagnosis-E. The PPV tended to decrease with age in both groups, with lower values seen in females. The prevalence was 3.84 per 1,000, and it was higher among males, chil­dren, and the elderly. Conclusions The prevalence of epilepsy in Korea was comparable to that in other East Asian countries. The diagnostic validity of administrative health data varies depending on the method of case ascertainment, age, and sex. The prescriptions of AEDs even without relevant diagnostic codes should be considered as a tracer for epilepsy.

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