Estimation method for brain activities are influenced by blood pulsation effect

W. H. Lee, Jeong Hun Ku, H. R. Lee, K. W. Han, J. S. Park, J. J. Kim, I. Y. Kim, S. I. Kim

Research output: Contribution to journalConference article


BOLD T2*-weighted MR images reflects cortical blood flow and oxygenation alterations. fMRI study relies on the detection of localized changes in BOLD signal intensity. Since fMRI measures the very small modulations in BOLD signal intensity that occur during changes in brain activity, it is also very sensitive to small signal intensity variations caused by physiologic noise during the scan. Due to the complexity of movement of various organs associated with heart beat, it is important to reduce cardiac related noise rather than other physiological noise which could be required with relatively simple method. Therefore, a number of methods have been developed for the estimation and reduction of cardiac noise in fMRI study. But, each method has limitation. In this study, we proposed a new estimation method for brain activities influenced by blood pulsation effect using regression analysis with blood pulsation signal and the correspond slice of fMRI. We could find out that the right anterior cingulate cortex and right olfactory cortex and left olfactory cortex were largely influenced by blood pulsation effect for new method. This observed areas are mostly on the structure of anterior cerebral artery in the brain. That is convinced with that our method would be valid and our new method is easier to apply in practice and reduce computational burden than the retrospective method.

Original languageEnglish
Pages (from-to)839-842
Number of pages4
JournalIFMBE Proceedings
Issue number1
Publication statusPublished - 2007 Jan 1
Event11th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2007 - Ljubljana, Slovenia
Duration: 2007 Jun 262007 Jun 30

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

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    Lee, W. H., Ku, J. H., Lee, H. R., Han, K. W., Park, J. S., Kim, J. J., Kim, I. Y., & Kim, S. I. (2007). Estimation method for brain activities are influenced by blood pulsation effect. IFMBE Proceedings, 16(1), 839-842.