Estimation of an Appropriate Human Dose of Boesenbergia pandurata Extracts Based on Allometric Scaling Data of Panduratin A in Mice, Rats, and Dogs

Seungmok Choi, Changhee Kim, Heebin Son, Jae Kwan Hwang, Wonku Kang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

It can be difficult to identify health/functional foods that exert therapeutic benefits for alleviating gingivitis and periodontitis. Recently, extracts of Boesenbergia pandurata (Roxb.), which is a tropical plant, have shown promising inhibitory activity against lipopolysaccharide-induced periodontitis. As a result, a clinical trial is being planned to assess utility of B. pandurata (Roxb.) extracts for promoting oral health; this study was designed to determine an appropriate human dose of the extracts for the trial. Pharmacokinetic studies of panduratin A, which is an active substance in fingerroot, were carried out in mice, rats, and dogs after oral administration of the extracts. The clearance data for each species were used to estimate clearance in humans through allometric scaling based on the maximum lifespan potential, and a daily dose providing sufficient anti-periodontitis activity was estimated for use in the clinical trial. The findings indicated that allometric scaling is a reasonable approach that is relatively free of safety issues and can be used to determine doses of substances for incorporation into health/functional foods appropriate for humans.

Original languageEnglish
Pages (from-to)453-458
Number of pages6
JournalJournal of medicinal food
Volume23
Issue number4
DOIs
Publication statusPublished - 2020 Apr

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (No. 2015R1A5A1008958), and by the World Class 300 project R&D grant funded by the Korea Small and Medium Business Administration (SMBA).

Publisher Copyright:
© Copyright 2020, Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition 2020.

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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