Estrogen release from metallic stent surface for the prevention of restenosis

Yoon Ki Joung, Hyun Il Kim, Sung Soo Kim, Kwang Hoe Chung, Yangsoo Jang, Ki Dong Park

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

For the prevention of coronary restenosis, estrogen was coupled onto a metallic stent and in vitro release of estrogen was investigated. Estrogen was introduced to the metal surface using a hydrolysable covalent bond for local sustained delivery of drug as follows: (i) the stainless steel (SS) surface was activated with silane by plasma polymerization, (ii) the activated surface (SS-Si surface) was treated with acrylic acid by plasma polymerization (SS-Si-AAc surface), and (iii) 17β-estradiol (E2) was covalently linked to the carboxyl group on that surface (SS-Si-AAc-E 2 surface). The modified surfaces were characterized by X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FT-IR) spectroscopy, and water contact angle measurement. The amount of E2 was measured by UV-visible spectrophotometry and high performance liquid chromatography (HPLC). The in vitro release profile of E2 demonstrated sustained release of E2 in aqueous buffer. In summary, a novel method of immobilizing estrogen onto a metallic stent surface using plasma polymerization has been developed. The obtained results attest to the usefulness of the estrogen-releasing stent for preventing restenosis.

Original languageEnglish
Pages (from-to)83-91
Number of pages9
JournalJournal of Controlled Release
Volume92
Issue number1-2
DOIs
Publication statusPublished - 2003 Sep 19

Fingerprint

Stents
Stainless Steel
Estrogens
Polymerization
Coronary Restenosis
Silanes
Photoelectron Spectroscopy
Spectrophotometry
Fourier Transform Infrared Spectroscopy
Estradiol
Buffers
Metals
High Pressure Liquid Chromatography
Water
Pharmaceutical Preparations
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Joung, Yoon Ki ; Kim, Hyun Il ; Kim, Sung Soo ; Chung, Kwang Hoe ; Jang, Yangsoo ; Park, Ki Dong. / Estrogen release from metallic stent surface for the prevention of restenosis. In: Journal of Controlled Release. 2003 ; Vol. 92, No. 1-2. pp. 83-91.
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Estrogen release from metallic stent surface for the prevention of restenosis. / Joung, Yoon Ki; Kim, Hyun Il; Kim, Sung Soo; Chung, Kwang Hoe; Jang, Yangsoo; Park, Ki Dong.

In: Journal of Controlled Release, Vol. 92, No. 1-2, 19.09.2003, p. 83-91.

Research output: Contribution to journalArticle

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T1 - Estrogen release from metallic stent surface for the prevention of restenosis

AU - Joung, Yoon Ki

AU - Kim, Hyun Il

AU - Kim, Sung Soo

AU - Chung, Kwang Hoe

AU - Jang, Yangsoo

AU - Park, Ki Dong

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N2 - For the prevention of coronary restenosis, estrogen was coupled onto a metallic stent and in vitro release of estrogen was investigated. Estrogen was introduced to the metal surface using a hydrolysable covalent bond for local sustained delivery of drug as follows: (i) the stainless steel (SS) surface was activated with silane by plasma polymerization, (ii) the activated surface (SS-Si surface) was treated with acrylic acid by plasma polymerization (SS-Si-AAc surface), and (iii) 17β-estradiol (E2) was covalently linked to the carboxyl group on that surface (SS-Si-AAc-E 2 surface). The modified surfaces were characterized by X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FT-IR) spectroscopy, and water contact angle measurement. The amount of E2 was measured by UV-visible spectrophotometry and high performance liquid chromatography (HPLC). The in vitro release profile of E2 demonstrated sustained release of E2 in aqueous buffer. In summary, a novel method of immobilizing estrogen onto a metallic stent surface using plasma polymerization has been developed. The obtained results attest to the usefulness of the estrogen-releasing stent for preventing restenosis.

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