Estrogen release from metallic stent surface for the prevention of restenosis

Yoon Ki Joung, Hyun Il Kim, Sung Soo Kim, Kwang Hoe Chung, Yang Soo Jang, Ki Dong Park

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

For the prevention of coronary restenosis, estrogen was coupled onto a metallic stent and in vitro release of estrogen was investigated. Estrogen was introduced to the metal surface using a hydrolysable covalent bond for local sustained delivery of drug as follows: (i) the stainless steel (SS) surface was activated with silane by plasma polymerization, (ii) the activated surface (SS-Si surface) was treated with acrylic acid by plasma polymerization (SS-Si-AAc surface), and (iii) 17β-estradiol (E2) was covalently linked to the carboxyl group on that surface (SS-Si-AAc-E 2 surface). The modified surfaces were characterized by X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FT-IR) spectroscopy, and water contact angle measurement. The amount of E2 was measured by UV-visible spectrophotometry and high performance liquid chromatography (HPLC). The in vitro release profile of E2 demonstrated sustained release of E2 in aqueous buffer. In summary, a novel method of immobilizing estrogen onto a metallic stent surface using plasma polymerization has been developed. The obtained results attest to the usefulness of the estrogen-releasing stent for preventing restenosis.

Original languageEnglish
Pages (from-to)83-91
Number of pages9
JournalJournal of Controlled Release
Volume92
Issue number1-2
DOIs
Publication statusPublished - 2003 Sep 19

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV11-0002).

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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