European 1: A globally important clonal complex of Mycobacterium bovis

Noel H. Smith, Stefan Berg, James Dale, Adrian Allen, Sabrina Rodriguez, Beatriz Romero, Filipa Matos, Solomon Ghebremichael, Claudine Karoui, Chiara Donati, Adelina da Conceicao Machado, Custodia Mucavele, Rudovick R. Kazwala, Markus Hilty, Simeon Cadmus, Bongo Naré Richard Ngandolo, Meseret Habtamu, James Oloya, Annélle Muller, Feliciano Milian-SuazoOlga Andrievskaia, Michaela Projahn, Soledad Barandiarán, Analía Macías, Borna Müller, Marcos Santos Zanini, Cassia Yumi Ikuta, Cesar Alejandro Rosales Rodriguez, Sônia Regina Pinheiro, Alvaro Figueroa, Sang Nae Cho, Nader Mosavari, Pei Chun Chuang, Ruwen Jou, Jakob Zinsstag, Dick van Soolingen, Eamonn Costello, Abraham Aseffa, Freddy Proaño-Perez, Françoise Portaels, Leen Rigouts, Angel Adrián Cataldi, Desmond M. Collins, María Laura Boschiroli, R. Glyn Hewinson, José Soares Ferreira Neto, Om Surujballi, Keyvan Tadyon, Ana Botelho, Ana María Zárraga, Nicky Buller, Robin Skuce, Anita Michel, Alicia Aranaz, Stephen V. Gordon, Bo Young Jeon, Gunilla Källenius, Stefan Niemann, M. Beatrice Boniotti, Paul D. van Helden, Beth Harris, Martín José Zumárraga, Kristin Kremer

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

We have identified a globally important clonal complex of Mycobacterium bovis by deletion analysis of over one thousand strains from over 30 countries. We initially show that over 99% of the strains of M. bovis, the cause of bovine tuberculosis, isolated from cattle in the Republic of Ireland and the UK are closely related and are members of a single clonal complex marked by the deletion of chromosomal region RDEu1 and we named this clonal complex European 1 (Eu1). Eu1 strains were present at less than 14% of French, Portuguese and Spanish isolates of M. bovis but are rare in other mainland European countries and Iran. However, strains of the Eu1 clonal complex were found at high frequency in former trading partners of the UK (USA, South Africa, New Zealand, Australia and Canada). The Americas, with the exception of Brazil, are dominated by the Eu1 clonal complex which was at high frequency in Argentina, Chile, Ecuador and Mexico as well as North America. Eu1 was rare or absent in the African countries surveyed except South Africa. A small sample of strains from Taiwan were non-Eu1 but, surprisingly, isolates from Korea and Kazakhstan were members of the Eu1 clonal complex. The simplest explanation for much of the current distribution of the Eu1 clonal complex is that it was spread in infected cattle, such as Herefords, from the UK to former trading partners, although there is evidence of secondary dispersion since. This is the first identification of a globally dispersed clonal complex M. bovis and indicates that much of the current global distribution of this important veterinary pathogen has resulted from relatively recent International trade in cattle.

Original languageEnglish
Pages (from-to)1340-1351
Number of pages12
JournalInfection, Genetics and Evolution
Volume11
Issue number6
DOIs
Publication statusPublished - 2011 Aug 1

Fingerprint

Mycobacterium bovis
cattle
South Africa
bovine tuberculosis
Kazakhstan
international trade
Bovine Tuberculosis
Ecuador
Chile
Argentina
Korea
pathogen
North America
Iran
Mexico
Taiwan
New Zealand
Ireland
Canada
Brazil

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Smith, N. H., Berg, S., Dale, J., Allen, A., Rodriguez, S., Romero, B., ... Kremer, K. (2011). European 1: A globally important clonal complex of Mycobacterium bovis. Infection, Genetics and Evolution, 11(6), 1340-1351. https://doi.org/10.1016/j.meegid.2011.04.027
Smith, Noel H. ; Berg, Stefan ; Dale, James ; Allen, Adrian ; Rodriguez, Sabrina ; Romero, Beatriz ; Matos, Filipa ; Ghebremichael, Solomon ; Karoui, Claudine ; Donati, Chiara ; Machado, Adelina da Conceicao ; Mucavele, Custodia ; Kazwala, Rudovick R. ; Hilty, Markus ; Cadmus, Simeon ; Ngandolo, Bongo Naré Richard ; Habtamu, Meseret ; Oloya, James ; Muller, Annélle ; Milian-Suazo, Feliciano ; Andrievskaia, Olga ; Projahn, Michaela ; Barandiarán, Soledad ; Macías, Analía ; Müller, Borna ; Zanini, Marcos Santos ; Ikuta, Cassia Yumi ; Rodriguez, Cesar Alejandro Rosales ; Pinheiro, Sônia Regina ; Figueroa, Alvaro ; Cho, Sang Nae ; Mosavari, Nader ; Chuang, Pei Chun ; Jou, Ruwen ; Zinsstag, Jakob ; van Soolingen, Dick ; Costello, Eamonn ; Aseffa, Abraham ; Proaño-Perez, Freddy ; Portaels, Françoise ; Rigouts, Leen ; Cataldi, Angel Adrián ; Collins, Desmond M. ; Boschiroli, María Laura ; Hewinson, R. Glyn ; Neto, José Soares Ferreira ; Surujballi, Om ; Tadyon, Keyvan ; Botelho, Ana ; Zárraga, Ana María ; Buller, Nicky ; Skuce, Robin ; Michel, Anita ; Aranaz, Alicia ; Gordon, Stephen V. ; Jeon, Bo Young ; Källenius, Gunilla ; Niemann, Stefan ; Boniotti, M. Beatrice ; van Helden, Paul D. ; Harris, Beth ; Zumárraga, Martín José ; Kremer, Kristin. / European 1 : A globally important clonal complex of Mycobacterium bovis. In: Infection, Genetics and Evolution. 2011 ; Vol. 11, No. 6. pp. 1340-1351.
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abstract = "We have identified a globally important clonal complex of Mycobacterium bovis by deletion analysis of over one thousand strains from over 30 countries. We initially show that over 99{\%} of the strains of M. bovis, the cause of bovine tuberculosis, isolated from cattle in the Republic of Ireland and the UK are closely related and are members of a single clonal complex marked by the deletion of chromosomal region RDEu1 and we named this clonal complex European 1 (Eu1). Eu1 strains were present at less than 14{\%} of French, Portuguese and Spanish isolates of M. bovis but are rare in other mainland European countries and Iran. However, strains of the Eu1 clonal complex were found at high frequency in former trading partners of the UK (USA, South Africa, New Zealand, Australia and Canada). The Americas, with the exception of Brazil, are dominated by the Eu1 clonal complex which was at high frequency in Argentina, Chile, Ecuador and Mexico as well as North America. Eu1 was rare or absent in the African countries surveyed except South Africa. A small sample of strains from Taiwan were non-Eu1 but, surprisingly, isolates from Korea and Kazakhstan were members of the Eu1 clonal complex. The simplest explanation for much of the current distribution of the Eu1 clonal complex is that it was spread in infected cattle, such as Herefords, from the UK to former trading partners, although there is evidence of secondary dispersion since. This is the first identification of a globally dispersed clonal complex M. bovis and indicates that much of the current global distribution of this important veterinary pathogen has resulted from relatively recent International trade in cattle.",
author = "Smith, {Noel H.} and Stefan Berg and James Dale and Adrian Allen and Sabrina Rodriguez and Beatriz Romero and Filipa Matos and Solomon Ghebremichael and Claudine Karoui and Chiara Donati and Machado, {Adelina da Conceicao} and Custodia Mucavele and Kazwala, {Rudovick R.} and Markus Hilty and Simeon Cadmus and Ngandolo, {Bongo Nar{\'e} Richard} and Meseret Habtamu and James Oloya and Ann{\'e}lle Muller and Feliciano Milian-Suazo and Olga Andrievskaia and Michaela Projahn and Soledad Barandiar{\'a}n and Anal{\'i}a Mac{\'i}as and Borna M{\"u}ller and Zanini, {Marcos Santos} and Ikuta, {Cassia Yumi} and Rodriguez, {Cesar Alejandro Rosales} and Pinheiro, {S{\^o}nia Regina} and Alvaro Figueroa and Cho, {Sang Nae} and Nader Mosavari and Chuang, {Pei Chun} and Ruwen Jou and Jakob Zinsstag and {van Soolingen}, Dick and Eamonn Costello and Abraham Aseffa and Freddy Proa{\~n}o-Perez and Fran{\cc}oise Portaels and Leen Rigouts and Cataldi, {Angel Adri{\'a}n} and Collins, {Desmond M.} and Boschiroli, {Mar{\'i}a Laura} and Hewinson, {R. Glyn} and Neto, {Jos{\'e} Soares Ferreira} and Om Surujballi and Keyvan Tadyon and Ana Botelho and Z{\'a}rraga, {Ana Mar{\'i}a} and Nicky Buller and Robin Skuce and Anita Michel and Alicia Aranaz and Gordon, {Stephen V.} and Jeon, {Bo Young} and Gunilla K{\"a}llenius and Stefan Niemann and Boniotti, {M. Beatrice} and {van Helden}, {Paul D.} and Beth Harris and Zum{\'a}rraga, {Mart{\'i}n Jos{\'e}} and Kristin Kremer",
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Smith, NH, Berg, S, Dale, J, Allen, A, Rodriguez, S, Romero, B, Matos, F, Ghebremichael, S, Karoui, C, Donati, C, Machado, ADC, Mucavele, C, Kazwala, RR, Hilty, M, Cadmus, S, Ngandolo, BNR, Habtamu, M, Oloya, J, Muller, A, Milian-Suazo, F, Andrievskaia, O, Projahn, M, Barandiarán, S, Macías, A, Müller, B, Zanini, MS, Ikuta, CY, Rodriguez, CAR, Pinheiro, SR, Figueroa, A, Cho, SN, Mosavari, N, Chuang, PC, Jou, R, Zinsstag, J, van Soolingen, D, Costello, E, Aseffa, A, Proaño-Perez, F, Portaels, F, Rigouts, L, Cataldi, AA, Collins, DM, Boschiroli, ML, Hewinson, RG, Neto, JSF, Surujballi, O, Tadyon, K, Botelho, A, Zárraga, AM, Buller, N, Skuce, R, Michel, A, Aranaz, A, Gordon, SV, Jeon, BY, Källenius, G, Niemann, S, Boniotti, MB, van Helden, PD, Harris, B, Zumárraga, MJ & Kremer, K 2011, 'European 1: A globally important clonal complex of Mycobacterium bovis', Infection, Genetics and Evolution, vol. 11, no. 6, pp. 1340-1351. https://doi.org/10.1016/j.meegid.2011.04.027

European 1 : A globally important clonal complex of Mycobacterium bovis. / Smith, Noel H.; Berg, Stefan; Dale, James; Allen, Adrian; Rodriguez, Sabrina; Romero, Beatriz; Matos, Filipa; Ghebremichael, Solomon; Karoui, Claudine; Donati, Chiara; Machado, Adelina da Conceicao; Mucavele, Custodia; Kazwala, Rudovick R.; Hilty, Markus; Cadmus, Simeon; Ngandolo, Bongo Naré Richard; Habtamu, Meseret; Oloya, James; Muller, Annélle; Milian-Suazo, Feliciano; Andrievskaia, Olga; Projahn, Michaela; Barandiarán, Soledad; Macías, Analía; Müller, Borna; Zanini, Marcos Santos; Ikuta, Cassia Yumi; Rodriguez, Cesar Alejandro Rosales; Pinheiro, Sônia Regina; Figueroa, Alvaro; Cho, Sang Nae; Mosavari, Nader; Chuang, Pei Chun; Jou, Ruwen; Zinsstag, Jakob; van Soolingen, Dick; Costello, Eamonn; Aseffa, Abraham; Proaño-Perez, Freddy; Portaels, Françoise; Rigouts, Leen; Cataldi, Angel Adrián; Collins, Desmond M.; Boschiroli, María Laura; Hewinson, R. Glyn; Neto, José Soares Ferreira; Surujballi, Om; Tadyon, Keyvan; Botelho, Ana; Zárraga, Ana María; Buller, Nicky; Skuce, Robin; Michel, Anita; Aranaz, Alicia; Gordon, Stephen V.; Jeon, Bo Young; Källenius, Gunilla; Niemann, Stefan; Boniotti, M. Beatrice; van Helden, Paul D.; Harris, Beth; Zumárraga, Martín José; Kremer, Kristin.

In: Infection, Genetics and Evolution, Vol. 11, No. 6, 01.08.2011, p. 1340-1351.

Research output: Contribution to journalArticle

TY - JOUR

T1 - European 1

T2 - A globally important clonal complex of Mycobacterium bovis

AU - Smith, Noel H.

AU - Berg, Stefan

AU - Dale, James

AU - Allen, Adrian

AU - Rodriguez, Sabrina

AU - Romero, Beatriz

AU - Matos, Filipa

AU - Ghebremichael, Solomon

AU - Karoui, Claudine

AU - Donati, Chiara

AU - Machado, Adelina da Conceicao

AU - Mucavele, Custodia

AU - Kazwala, Rudovick R.

AU - Hilty, Markus

AU - Cadmus, Simeon

AU - Ngandolo, Bongo Naré Richard

AU - Habtamu, Meseret

AU - Oloya, James

AU - Muller, Annélle

AU - Milian-Suazo, Feliciano

AU - Andrievskaia, Olga

AU - Projahn, Michaela

AU - Barandiarán, Soledad

AU - Macías, Analía

AU - Müller, Borna

AU - Zanini, Marcos Santos

AU - Ikuta, Cassia Yumi

AU - Rodriguez, Cesar Alejandro Rosales

AU - Pinheiro, Sônia Regina

AU - Figueroa, Alvaro

AU - Cho, Sang Nae

AU - Mosavari, Nader

AU - Chuang, Pei Chun

AU - Jou, Ruwen

AU - Zinsstag, Jakob

AU - van Soolingen, Dick

AU - Costello, Eamonn

AU - Aseffa, Abraham

AU - Proaño-Perez, Freddy

AU - Portaels, Françoise

AU - Rigouts, Leen

AU - Cataldi, Angel Adrián

AU - Collins, Desmond M.

AU - Boschiroli, María Laura

AU - Hewinson, R. Glyn

AU - Neto, José Soares Ferreira

AU - Surujballi, Om

AU - Tadyon, Keyvan

AU - Botelho, Ana

AU - Zárraga, Ana María

AU - Buller, Nicky

AU - Skuce, Robin

AU - Michel, Anita

AU - Aranaz, Alicia

AU - Gordon, Stephen V.

AU - Jeon, Bo Young

AU - Källenius, Gunilla

AU - Niemann, Stefan

AU - Boniotti, M. Beatrice

AU - van Helden, Paul D.

AU - Harris, Beth

AU - Zumárraga, Martín José

AU - Kremer, Kristin

PY - 2011/8/1

Y1 - 2011/8/1

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