Eutectic mixture of local anesthesia cream can reduce both the radial pain and sympathetic response during transradial coronary angiography

Youngjin Youn, Woo Taek Kim, Junwon Lee, Sung Gyun Ahn, Minsoo Ahn, Jang Young Kim, Byungsu Yoo, Seunghwan Lee, Junghan Yoon, Kyung Hoon Choe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background and Objectives: Radial artery spasm is one of the most common complications of transradial coronary angiography (TRA): the radial artery is prone to cathecholamine-induced contraction and radial pain during TRA could increase the sympathetic tone. The object of this study was to evaluate whether the eutectic mixture of local anesthesia (EMLA) cream, in addition to lidocaine infiltration, could reduce the sympathetic response by reducing radial pain during TRA. Subjects and Methods: Seventy-six patients were randomized 1:1 to either EMLA or control groups. Radial pain was measured by the visual analogue scale (VAS) and the verbal rating scale (VRS-4). Sympathetic response, including systolic (SBP) and diastolic blood pressure (DBP), pulse rate (PR), stroke volume (SV) and total peripheral resistance (TPR), was measured by photoplethysmography. Results: Radial pain measured during lidocaine infiltration was significantly lower in the EMLA group (VAS: 3.1 vs. 4.0, p=0.04; VRS-4: 2.0 vs. 2.2, p=0.03) and the sympathetic response was significantly blunted in the EMLA group from baseline to lidocaine infiltration (ΔSBP, mm Hg: 5 vs. 13, p<0.01; ΔDBP, mm Hg: 2 vs. 7, p=0.03; ΔPR, beat/min: 2 vs. 8, p<0.01, ΔSV, mL: 3 vs. 21, p<0.01; ΔTPR, mm Hg·L/min: 1.0 vs. 5.9, p<0.01). Conclusion: In patients undergoing TRA, the EMLA cream, in addition to lidocaine infiltration, effectively reduces the radial pain and thereby the sympathetic response, during lidocaine infiltration.

Original languageEnglish
Pages (from-to)726-732
Number of pages7
JournalKorean Circulation Journal
Volume41
Issue number12
DOIs
Publication statusPublished - 2011 Dec 1

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Local Anesthesia
Lidocaine
Coronary Angiography
Pain
Blood Pressure
Radial Artery
Visual Analog Scale
Vascular Resistance
Stroke Volume
Heart Rate
Photoplethysmography
Spasm
Control Groups

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

@article{5b89f98f5f3a490a9e1d96978d8ac00b,
title = "Eutectic mixture of local anesthesia cream can reduce both the radial pain and sympathetic response during transradial coronary angiography",
abstract = "Background and Objectives: Radial artery spasm is one of the most common complications of transradial coronary angiography (TRA): the radial artery is prone to cathecholamine-induced contraction and radial pain during TRA could increase the sympathetic tone. The object of this study was to evaluate whether the eutectic mixture of local anesthesia (EMLA) cream, in addition to lidocaine infiltration, could reduce the sympathetic response by reducing radial pain during TRA. Subjects and Methods: Seventy-six patients were randomized 1:1 to either EMLA or control groups. Radial pain was measured by the visual analogue scale (VAS) and the verbal rating scale (VRS-4). Sympathetic response, including systolic (SBP) and diastolic blood pressure (DBP), pulse rate (PR), stroke volume (SV) and total peripheral resistance (TPR), was measured by photoplethysmography. Results: Radial pain measured during lidocaine infiltration was significantly lower in the EMLA group (VAS: 3.1 vs. 4.0, p=0.04; VRS-4: 2.0 vs. 2.2, p=0.03) and the sympathetic response was significantly blunted in the EMLA group from baseline to lidocaine infiltration (ΔSBP, mm Hg: 5 vs. 13, p<0.01; ΔDBP, mm Hg: 2 vs. 7, p=0.03; ΔPR, beat/min: 2 vs. 8, p<0.01, ΔSV, mL: 3 vs. 21, p<0.01; ΔTPR, mm Hg·L/min: 1.0 vs. 5.9, p<0.01). Conclusion: In patients undergoing TRA, the EMLA cream, in addition to lidocaine infiltration, effectively reduces the radial pain and thereby the sympathetic response, during lidocaine infiltration.",
author = "Youngjin Youn and Kim, {Woo Taek} and Junwon Lee and Ahn, {Sung Gyun} and Minsoo Ahn and Kim, {Jang Young} and Byungsu Yoo and Seunghwan Lee and Junghan Yoon and Choe, {Kyung Hoon}",
year = "2011",
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doi = "10.4070/kcj.2011.41.12.726",
language = "English",
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pages = "726--732",
journal = "Korean Circulation Journal",
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}

Eutectic mixture of local anesthesia cream can reduce both the radial pain and sympathetic response during transradial coronary angiography. / Youn, Youngjin; Kim, Woo Taek; Lee, Junwon; Ahn, Sung Gyun; Ahn, Minsoo; Kim, Jang Young; Yoo, Byungsu; Lee, Seunghwan; Yoon, Junghan; Choe, Kyung Hoon.

In: Korean Circulation Journal, Vol. 41, No. 12, 01.12.2011, p. 726-732.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Eutectic mixture of local anesthesia cream can reduce both the radial pain and sympathetic response during transradial coronary angiography

AU - Youn, Youngjin

AU - Kim, Woo Taek

AU - Lee, Junwon

AU - Ahn, Sung Gyun

AU - Ahn, Minsoo

AU - Kim, Jang Young

AU - Yoo, Byungsu

AU - Lee, Seunghwan

AU - Yoon, Junghan

AU - Choe, Kyung Hoon

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background and Objectives: Radial artery spasm is one of the most common complications of transradial coronary angiography (TRA): the radial artery is prone to cathecholamine-induced contraction and radial pain during TRA could increase the sympathetic tone. The object of this study was to evaluate whether the eutectic mixture of local anesthesia (EMLA) cream, in addition to lidocaine infiltration, could reduce the sympathetic response by reducing radial pain during TRA. Subjects and Methods: Seventy-six patients were randomized 1:1 to either EMLA or control groups. Radial pain was measured by the visual analogue scale (VAS) and the verbal rating scale (VRS-4). Sympathetic response, including systolic (SBP) and diastolic blood pressure (DBP), pulse rate (PR), stroke volume (SV) and total peripheral resistance (TPR), was measured by photoplethysmography. Results: Radial pain measured during lidocaine infiltration was significantly lower in the EMLA group (VAS: 3.1 vs. 4.0, p=0.04; VRS-4: 2.0 vs. 2.2, p=0.03) and the sympathetic response was significantly blunted in the EMLA group from baseline to lidocaine infiltration (ΔSBP, mm Hg: 5 vs. 13, p<0.01; ΔDBP, mm Hg: 2 vs. 7, p=0.03; ΔPR, beat/min: 2 vs. 8, p<0.01, ΔSV, mL: 3 vs. 21, p<0.01; ΔTPR, mm Hg·L/min: 1.0 vs. 5.9, p<0.01). Conclusion: In patients undergoing TRA, the EMLA cream, in addition to lidocaine infiltration, effectively reduces the radial pain and thereby the sympathetic response, during lidocaine infiltration.

AB - Background and Objectives: Radial artery spasm is one of the most common complications of transradial coronary angiography (TRA): the radial artery is prone to cathecholamine-induced contraction and radial pain during TRA could increase the sympathetic tone. The object of this study was to evaluate whether the eutectic mixture of local anesthesia (EMLA) cream, in addition to lidocaine infiltration, could reduce the sympathetic response by reducing radial pain during TRA. Subjects and Methods: Seventy-six patients were randomized 1:1 to either EMLA or control groups. Radial pain was measured by the visual analogue scale (VAS) and the verbal rating scale (VRS-4). Sympathetic response, including systolic (SBP) and diastolic blood pressure (DBP), pulse rate (PR), stroke volume (SV) and total peripheral resistance (TPR), was measured by photoplethysmography. Results: Radial pain measured during lidocaine infiltration was significantly lower in the EMLA group (VAS: 3.1 vs. 4.0, p=0.04; VRS-4: 2.0 vs. 2.2, p=0.03) and the sympathetic response was significantly blunted in the EMLA group from baseline to lidocaine infiltration (ΔSBP, mm Hg: 5 vs. 13, p<0.01; ΔDBP, mm Hg: 2 vs. 7, p=0.03; ΔPR, beat/min: 2 vs. 8, p<0.01, ΔSV, mL: 3 vs. 21, p<0.01; ΔTPR, mm Hg·L/min: 1.0 vs. 5.9, p<0.01). Conclusion: In patients undergoing TRA, the EMLA cream, in addition to lidocaine infiltration, effectively reduces the radial pain and thereby the sympathetic response, during lidocaine infiltration.

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