Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: A multicentre cohort analysis

Seon Sook Han, Su Jin Lee, Jae Joon Yim, Jin Hwa Song, Eun Hye Lee, Young Ae Kang

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8 Citations (Scopus)


Objective Healthcare workers (HCWs) are one of the target groups for systematic testing and treatment of latent tuberculosis infection (LTBI) in a setting of low TB incidence. We performed this study to describe the testing of HCWs for LTBI and analyse the acceptance and completion of treatment of LTBI. Methods This retrospective cohort study was conducted in four university-affiliated hospitals between January 1 and December 31, 2018. HCWs with positive interferon-gamma release assay (IGRA) during LTBI screening were analysed. We assessed the acceptance and completion of LTBI treatment. Results Overall, 893 HCWs were IGRA positive. Among them, 609 HCWs visited the clinic for evaluation of LTBI. Of 609 HCWs who were evaluated, 302 (49.6%) were offered treatment for LTBI. The proportion of acceptance for treatment was 64.5% (195 of 302 HCWs). The treatment course was completed by 143 of 195 HCWs (73.3%). Three months of isoniazid and rifampin (3HR) was used in 137 HCWs (70.3%) and 4 months of rifampin (4R) in 58 (29.7%). 72 HCWs (36.9%) experienced at least one adverse drug events, but there was no different characteristics between completer and non-completer. Conclusion The acceptance and completion of LTBI treatment were unsatisfactory. Subjective perspective regarding obstacles to treatment of LTBI needs to be explored to increase compliance to LTBI treatment.

Original languageEnglish
Article numbere0222810
JournalPloS one
Issue number9
Publication statusPublished - 2019 Sept 1

Bibliographical note

Funding Information:
The present study was supported by a faculty research grant from Yonsei University College of Medicine, Seoul, South Korea (6-2017-0150) to YAK. The funding source had no role in the study process, including the design, sample collection, analysis, or interpretation of the results.

Publisher Copyright:
© 2019 Han et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

All Science Journal Classification (ASJC) codes

  • General


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