Evaluation of algorithms for intracranial EEG (iEEG) source imaging of extended sources: Feasibility of using iEEG source imaging for localizing epileptogenic zones in secondary generalized epilepsy

Jae Hyun Cho, Seung Bong Hong, Young Jin Jung, hoonchul kang, HeungDong Kim, Minah Suh, Ki Young Jung, Chang Hwan Im

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Precise identification of epileptogenic zones in patients with intractable drug-resistant epilepsy is critical for successful epilepsy surgery. Numerous source-imaging algorithms for localizing epileptogenic zones based on scalp electroencephalography (EEG) and magnetoencephalography (MEG) have been developed and validated in simulation and experimental studies. Recently, intracranial EEG (iEEG)-based imaging of epileptogenic sources has attracted interest as a promising tool for presurgical evaluation of epilepsy; however, most iEEG studies have focused on localization of epileptogenic zones in focal epilepsy. In the present study, we investigated whether iEEG source imaging is a useful supplementary tool for identifying extended epileptogenic sources in secondary generalized epilepsy such as Lennox- Gastaut syndrome (LGS). To this end, we applied four different cortical source imaging algorithms, namely minimum norm estimation (MNE), low-resolution electromagnetic tomography (LORETA), standardized LORETA (sLORETA), and L p-norm estimation (p = 1.5, referred to as L p1.5), to artificial iEEG datasets generated assuming various source sizes and locations. We also applied these four algorithms to clinical ictal iEEG recordings acquired from a pediatric patient with LGS. Interestingly, the traditional MNE algorithm outperformed the other imaging algorithms in most of our experiments, particularly in cases when larger-sized sources were activated. Although sLORETA outperformed both LORETA and Lp1.5, its performance was not as good as that of MNE. Compared to the other algorithms, the performance of Lp1.5 decayed most rapidly as the source size increased. Our findings suggest that iEEG source imaging using MNE is a promising auxiliary tool for the identification of epileptogenic zones in secondary generalized epilepsy. We anticipate that our results will provide useful guidelines for selection of an appropriate imaging algorithm for iEEG source imaging studies.

Original languageEnglish
Pages (from-to)91-104
Number of pages14
JournalBrain Topography
Volume24
Issue number2
DOIs
Publication statusPublished - 2011 Jun 1

Fingerprint

Generalized Epilepsy
Electromagnetic Phenomena
Tomography
Epilepsy
Magnetoencephalography
Partial Epilepsy
Electrocorticography
Scalp
Electroencephalography
Stroke
Guidelines
Pediatrics

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

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title = "Evaluation of algorithms for intracranial EEG (iEEG) source imaging of extended sources: Feasibility of using iEEG source imaging for localizing epileptogenic zones in secondary generalized epilepsy",
abstract = "Precise identification of epileptogenic zones in patients with intractable drug-resistant epilepsy is critical for successful epilepsy surgery. Numerous source-imaging algorithms for localizing epileptogenic zones based on scalp electroencephalography (EEG) and magnetoencephalography (MEG) have been developed and validated in simulation and experimental studies. Recently, intracranial EEG (iEEG)-based imaging of epileptogenic sources has attracted interest as a promising tool for presurgical evaluation of epilepsy; however, most iEEG studies have focused on localization of epileptogenic zones in focal epilepsy. In the present study, we investigated whether iEEG source imaging is a useful supplementary tool for identifying extended epileptogenic sources in secondary generalized epilepsy such as Lennox- Gastaut syndrome (LGS). To this end, we applied four different cortical source imaging algorithms, namely minimum norm estimation (MNE), low-resolution electromagnetic tomography (LORETA), standardized LORETA (sLORETA), and L p-norm estimation (p = 1.5, referred to as L p1.5), to artificial iEEG datasets generated assuming various source sizes and locations. We also applied these four algorithms to clinical ictal iEEG recordings acquired from a pediatric patient with LGS. Interestingly, the traditional MNE algorithm outperformed the other imaging algorithms in most of our experiments, particularly in cases when larger-sized sources were activated. Although sLORETA outperformed both LORETA and Lp1.5, its performance was not as good as that of MNE. Compared to the other algorithms, the performance of Lp1.5 decayed most rapidly as the source size increased. Our findings suggest that iEEG source imaging using MNE is a promising auxiliary tool for the identification of epileptogenic zones in secondary generalized epilepsy. We anticipate that our results will provide useful guidelines for selection of an appropriate imaging algorithm for iEEG source imaging studies.",
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Evaluation of algorithms for intracranial EEG (iEEG) source imaging of extended sources : Feasibility of using iEEG source imaging for localizing epileptogenic zones in secondary generalized epilepsy. / Cho, Jae Hyun; Hong, Seung Bong; Jung, Young Jin; kang, hoonchul; Kim, HeungDong; Suh, Minah; Jung, Ki Young; Im, Chang Hwan.

In: Brain Topography, Vol. 24, No. 2, 01.06.2011, p. 91-104.

Research output: Contribution to journalArticle

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