Evaluation of cardiac sympathetic neuronal integrity in diabetic patients using iodine-123 metaiodobenzylguanidine

Sun Jung Kim, Jong Doo Lee, Young Hoon Ryu, Pyoung Jeon, Yong Woon Shim, Hyung Sik Yoo, Chang Yun Park, Sungkil Lim

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Abstract

Autonomic dysfunction is associated with increased mortality in diabetic patients. To evaluate the cardiac autonomic dysfunction in these patients, a prospective study was undertaken using iodine-123 metaiodobenzylguanidine (MIBG) single-photon emission tomography (SPET). The study groups consisted of ten diabetic patients with cardiac autonomic neuropathy (group I) and six without autonomic neuropathy (group II). Autonomic nervous function tests, thallium scan, radionuclide ventriculographic data including ejection fraction and wall motion study, and 24-h urine catecholamine levels were evaluated. 123I-MIBG SPET was performed at 30 min and 4 h following injection of 3 mCi of 123I-MIBG in groups I and II and in normal subjects (n = 4). On planar images, the heart to mediastinum (H/M) ratio was measured. Defect pattern and severity of MIBG uptake were qualitatively analysed on SPET. Compared with control subjects, diabetic patients had a reduced H/M ratio regardless of the presence of clinical autonomic neuropathy. There was no difference in H/M ratio between groups I and II. On SPET images, focal or diffuse defects were demonstrated in all patients in group I, and in five of the six patients in group II. The extent of defects tended to be more pronounced in group I than in group II. In conclusion, 123I-MIBG scan was found to be a more sensitive method than clinical autonomic nervous function tests for the detection of autonomic neuropathy in diabetes.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalEuropean Journal Of Nuclear Medicine
Volume23
Issue number4
DOIs
Publication statusPublished - 1996 May 1

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Iodine
Photons
Mediastinum
Tomography
Thallium
Radioisotopes
Catecholamines
Urine
Prospective Studies
Injections
Mortality

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kim, Sun Jung ; Lee, Jong Doo ; Ryu, Young Hoon ; Jeon, Pyoung ; Shim, Yong Woon ; Yoo, Hyung Sik ; Park, Chang Yun ; Lim, Sungkil. / Evaluation of cardiac sympathetic neuronal integrity in diabetic patients using iodine-123 metaiodobenzylguanidine. In: European Journal Of Nuclear Medicine. 1996 ; Vol. 23, No. 4. pp. 401-406.
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abstract = "Autonomic dysfunction is associated with increased mortality in diabetic patients. To evaluate the cardiac autonomic dysfunction in these patients, a prospective study was undertaken using iodine-123 metaiodobenzylguanidine (MIBG) single-photon emission tomography (SPET). The study groups consisted of ten diabetic patients with cardiac autonomic neuropathy (group I) and six without autonomic neuropathy (group II). Autonomic nervous function tests, thallium scan, radionuclide ventriculographic data including ejection fraction and wall motion study, and 24-h urine catecholamine levels were evaluated. 123I-MIBG SPET was performed at 30 min and 4 h following injection of 3 mCi of 123I-MIBG in groups I and II and in normal subjects (n = 4). On planar images, the heart to mediastinum (H/M) ratio was measured. Defect pattern and severity of MIBG uptake were qualitatively analysed on SPET. Compared with control subjects, diabetic patients had a reduced H/M ratio regardless of the presence of clinical autonomic neuropathy. There was no difference in H/M ratio between groups I and II. On SPET images, focal or diffuse defects were demonstrated in all patients in group I, and in five of the six patients in group II. The extent of defects tended to be more pronounced in group I than in group II. In conclusion, 123I-MIBG scan was found to be a more sensitive method than clinical autonomic nervous function tests for the detection of autonomic neuropathy in diabetes.",
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Evaluation of cardiac sympathetic neuronal integrity in diabetic patients using iodine-123 metaiodobenzylguanidine. / Kim, Sun Jung; Lee, Jong Doo; Ryu, Young Hoon; Jeon, Pyoung; Shim, Yong Woon; Yoo, Hyung Sik; Park, Chang Yun; Lim, Sungkil.

In: European Journal Of Nuclear Medicine, Vol. 23, No. 4, 01.05.1996, p. 401-406.

Research output: Contribution to journalArticle

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