Evaluation of cell-mediated immune responses to two BCG vaccination regimes in young children in South Korea

Hyejon Lee, Sang Nae Cho, Hee Jin Kim, Young Min Anh, Ji Eun Choi, Chang Hwi Kim, Park Jae Ock, Sung Hee Oh, Deok Ryun Kim, Sian Floyd, Hazel M. Dockrell

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Children in South Korea are vaccinated with either BCG Pasteur vaccine intradermally (ID), or with BCG Tokyo vaccine given by multipuncture device (MP). Data from a recent national survey indicated that in children under 6 years old, 31.1% had received the ID vaccine and 64.5% the MP vaccine. To compare the T cell responses induced by the two vaccines, children aged 3-7 were recruited and tested for tuberculin skin test reactivity and for in vitro IFN-γ responses to mycobacterial antigens. DTH responses were not significantly different in children vaccinated by either the ID or MP vaccines. PPD-induced IFN-γ was measured in supernatants of 6-day diluted whole blood cultures. IFN-γ production to PPD was not significantly different in the two vaccine groups, although there is a trend that the MP group gives a higher proportion of IFN-γ positivity than the ID group. In addition, when IFN-γ responses to the antigens ESAT-6 and CFP-10 were assessed in the 6-7 year old group, there was no significant difference between the two vaccine groups. Thus, there was no evidence that the increasing use of MP vaccination has reduced protection against M. tuberculosis in young children in South Korea, based on immunogenicity as assessed by DTH and IFN-γ responses to PPD, and also equivalent frequency of responses to ESAT-6 and CFP-10.

Original languageEnglish
Pages (from-to)6564-6571
Number of pages8
JournalVaccine
Volume29
Issue number38
DOIs
Publication statusPublished - 2011 Sep 2

Fingerprint

Republic of Korea
South Korea
Mycobacterium bovis
cell-mediated immunity
Vaccination
Vaccines
vaccination
vaccines
Tuberculin
Equipment and Supplies
BCG vaccine
BCG Vaccine
antigens
Antigens
Tuberculin Test
tuberculin
skin tests
Tokyo
national surveys
Skin Tests

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Lee, Hyejon ; Cho, Sang Nae ; Kim, Hee Jin ; Anh, Young Min ; Choi, Ji Eun ; Kim, Chang Hwi ; Ock, Park Jae ; Oh, Sung Hee ; Kim, Deok Ryun ; Floyd, Sian ; Dockrell, Hazel M. / Evaluation of cell-mediated immune responses to two BCG vaccination regimes in young children in South Korea. In: Vaccine. 2011 ; Vol. 29, No. 38. pp. 6564-6571.
@article{835b4c83720e48fcbf6fcb333228937e,
title = "Evaluation of cell-mediated immune responses to two BCG vaccination regimes in young children in South Korea",
abstract = "Children in South Korea are vaccinated with either BCG Pasteur vaccine intradermally (ID), or with BCG Tokyo vaccine given by multipuncture device (MP). Data from a recent national survey indicated that in children under 6 years old, 31.1{\%} had received the ID vaccine and 64.5{\%} the MP vaccine. To compare the T cell responses induced by the two vaccines, children aged 3-7 were recruited and tested for tuberculin skin test reactivity and for in vitro IFN-γ responses to mycobacterial antigens. DTH responses were not significantly different in children vaccinated by either the ID or MP vaccines. PPD-induced IFN-γ was measured in supernatants of 6-day diluted whole blood cultures. IFN-γ production to PPD was not significantly different in the two vaccine groups, although there is a trend that the MP group gives a higher proportion of IFN-γ positivity than the ID group. In addition, when IFN-γ responses to the antigens ESAT-6 and CFP-10 were assessed in the 6-7 year old group, there was no significant difference between the two vaccine groups. Thus, there was no evidence that the increasing use of MP vaccination has reduced protection against M. tuberculosis in young children in South Korea, based on immunogenicity as assessed by DTH and IFN-γ responses to PPD, and also equivalent frequency of responses to ESAT-6 and CFP-10.",
author = "Hyejon Lee and Cho, {Sang Nae} and Kim, {Hee Jin} and Anh, {Young Min} and Choi, {Ji Eun} and Kim, {Chang Hwi} and Ock, {Park Jae} and Oh, {Sung Hee} and Kim, {Deok Ryun} and Sian Floyd and Dockrell, {Hazel M.}",
year = "2011",
month = "9",
day = "2",
doi = "10.1016/j.vaccine.2011.07.003",
language = "English",
volume = "29",
pages = "6564--6571",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "38",

}

Lee, H, Cho, SN, Kim, HJ, Anh, YM, Choi, JE, Kim, CH, Ock, PJ, Oh, SH, Kim, DR, Floyd, S & Dockrell, HM 2011, 'Evaluation of cell-mediated immune responses to two BCG vaccination regimes in young children in South Korea', Vaccine, vol. 29, no. 38, pp. 6564-6571. https://doi.org/10.1016/j.vaccine.2011.07.003

Evaluation of cell-mediated immune responses to two BCG vaccination regimes in young children in South Korea. / Lee, Hyejon; Cho, Sang Nae; Kim, Hee Jin; Anh, Young Min; Choi, Ji Eun; Kim, Chang Hwi; Ock, Park Jae; Oh, Sung Hee; Kim, Deok Ryun; Floyd, Sian; Dockrell, Hazel M.

In: Vaccine, Vol. 29, No. 38, 02.09.2011, p. 6564-6571.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of cell-mediated immune responses to two BCG vaccination regimes in young children in South Korea

AU - Lee, Hyejon

AU - Cho, Sang Nae

AU - Kim, Hee Jin

AU - Anh, Young Min

AU - Choi, Ji Eun

AU - Kim, Chang Hwi

AU - Ock, Park Jae

AU - Oh, Sung Hee

AU - Kim, Deok Ryun

AU - Floyd, Sian

AU - Dockrell, Hazel M.

PY - 2011/9/2

Y1 - 2011/9/2

N2 - Children in South Korea are vaccinated with either BCG Pasteur vaccine intradermally (ID), or with BCG Tokyo vaccine given by multipuncture device (MP). Data from a recent national survey indicated that in children under 6 years old, 31.1% had received the ID vaccine and 64.5% the MP vaccine. To compare the T cell responses induced by the two vaccines, children aged 3-7 were recruited and tested for tuberculin skin test reactivity and for in vitro IFN-γ responses to mycobacterial antigens. DTH responses were not significantly different in children vaccinated by either the ID or MP vaccines. PPD-induced IFN-γ was measured in supernatants of 6-day diluted whole blood cultures. IFN-γ production to PPD was not significantly different in the two vaccine groups, although there is a trend that the MP group gives a higher proportion of IFN-γ positivity than the ID group. In addition, when IFN-γ responses to the antigens ESAT-6 and CFP-10 were assessed in the 6-7 year old group, there was no significant difference between the two vaccine groups. Thus, there was no evidence that the increasing use of MP vaccination has reduced protection against M. tuberculosis in young children in South Korea, based on immunogenicity as assessed by DTH and IFN-γ responses to PPD, and also equivalent frequency of responses to ESAT-6 and CFP-10.

AB - Children in South Korea are vaccinated with either BCG Pasteur vaccine intradermally (ID), or with BCG Tokyo vaccine given by multipuncture device (MP). Data from a recent national survey indicated that in children under 6 years old, 31.1% had received the ID vaccine and 64.5% the MP vaccine. To compare the T cell responses induced by the two vaccines, children aged 3-7 were recruited and tested for tuberculin skin test reactivity and for in vitro IFN-γ responses to mycobacterial antigens. DTH responses were not significantly different in children vaccinated by either the ID or MP vaccines. PPD-induced IFN-γ was measured in supernatants of 6-day diluted whole blood cultures. IFN-γ production to PPD was not significantly different in the two vaccine groups, although there is a trend that the MP group gives a higher proportion of IFN-γ positivity than the ID group. In addition, when IFN-γ responses to the antigens ESAT-6 and CFP-10 were assessed in the 6-7 year old group, there was no significant difference between the two vaccine groups. Thus, there was no evidence that the increasing use of MP vaccination has reduced protection against M. tuberculosis in young children in South Korea, based on immunogenicity as assessed by DTH and IFN-γ responses to PPD, and also equivalent frequency of responses to ESAT-6 and CFP-10.

UR - http://www.scopus.com/inward/record.url?scp=80051664274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051664274&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2011.07.003

DO - 10.1016/j.vaccine.2011.07.003

M3 - Article

C2 - 21763746

AN - SCOPUS:80051664274

VL - 29

SP - 6564

EP - 6571

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 38

ER -