Evaluation of changes in neural oscillation after bilateral capsulotomy in treatment refractory obsessive-compulsive disorder using magnetoencephalogram

Jhin goo Chang; Do Won Kim; Hyun Ho Jung; Won Seok Chang; Chan Hyung Kim; Se Joo Kim; Jin Woo Chang

doi:10.1016/j.ajp.2023.103473

Evaluation of changes in neural oscillation after bilateral capsulotomy in treatment refractory obsessive-compulsive disorder using magnetoencephalogram

Jhin goo Chang, Do Won Kim, Hyun Ho Jung, Won Seok Chang, Chan Hyung Kim, Se Joo Kim, Jin Woo Chang

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

Abstract

Bilateral thermal capsulotomy with magnetic resonance-guided focused ultrasound (MRgFUS-capsulotomy) is a promising treatment option for treatment-refractory obsessive-compulsive disorder (OCD). Herein, we investigated the effects of bilateral thermal capsulotomy with MRgFUS on neural oscillations in treatment-refractory OCD patients. Eight patients underwent resting-state MEG with repeated recordings before and 1 and 6 months after MRgFUS-capsulotomy, and the oscillatory power and phase coherence over the entire cortical sensor area were measured. After MRgFUS-capsulotomy, the high beta band power in the fronto-central and temporal areas decreased at 1 month and remained stable for 6 months. Cortical connectivity of the high beta band gradually decreased over the entire cortical area during the following 6 months. At 1 month, improvement in anxiety and depression symptoms was significantly correlated with changes in high beta band power in both the frontotemporal and temporal areas. The treatment effect of MRgFUS-capsulotomy may be attributed to the cortical high beta band. Our results provide an advanced understanding of the neural mechanisms underlying MRgFUS-capsulotomy and other neuromodulatory interventions for treatment-refractory OCD.

Original language	English
Article number	103473
Journal	Asian Journal of Psychiatry
Volume	82
DOIs	https://doi.org/10.1016/j.ajp.2023.103473
Publication status	Published - 2023 Apr

Bibliographical note

Funding Information:
This study was supported by the Focused Ultrasound Foundation (Charlottesville, VA, USA). The sponsor played no role in the study design, data collection, data analysis, data interpretation, writing of the report, or decision to submit the paper for publication. JWC had full access to all the data associated with this research and had the final responsibility for deciding to submit this manuscript for publication.

Funding Information:
This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government ( NRF-2021M3E5D9025022 and 2018R1A2B2007714 to SJ Kim). The funding source did not influence the study design, data collection, analysis and interpretation of data, writing of the report, or decision to submit the article for publication.

Publisher Copyright:
© 2023

All Science Journal Classification (ASJC) codes

Psychology(all)
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ajp.2023.103473

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title = "Evaluation of changes in neural oscillation after bilateral capsulotomy in treatment refractory obsessive-compulsive disorder using magnetoencephalogram",

abstract = "Bilateral thermal capsulotomy with magnetic resonance-guided focused ultrasound (MRgFUS-capsulotomy) is a promising treatment option for treatment-refractory obsessive-compulsive disorder (OCD). Herein, we investigated the effects of bilateral thermal capsulotomy with MRgFUS on neural oscillations in treatment-refractory OCD patients. Eight patients underwent resting-state MEG with repeated recordings before and 1 and 6 months after MRgFUS-capsulotomy, and the oscillatory power and phase coherence over the entire cortical sensor area were measured. After MRgFUS-capsulotomy, the high beta band power in the fronto-central and temporal areas decreased at 1 month and remained stable for 6 months. Cortical connectivity of the high beta band gradually decreased over the entire cortical area during the following 6 months. At 1 month, improvement in anxiety and depression symptoms was significantly correlated with changes in high beta band power in both the frontotemporal and temporal areas. The treatment effect of MRgFUS-capsulotomy may be attributed to the cortical high beta band. Our results provide an advanced understanding of the neural mechanisms underlying MRgFUS-capsulotomy and other neuromodulatory interventions for treatment-refractory OCD.",

author = "Chang, {Jhin goo} and Kim, {Do Won} and Jung, {Hyun Ho} and Chang, {Won Seok} and Kim, {Chan Hyung} and Kim, {Se Joo} and Chang, {Jin Woo}",

note = "Funding Information: This study was supported by the Focused Ultrasound Foundation (Charlottesville, VA, USA). The sponsor played no role in the study design, data collection, data analysis, data interpretation, writing of the report, or decision to submit the paper for publication. JWC had full access to all the data associated with this research and had the final responsibility for deciding to submit this manuscript for publication. Funding Information: This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government ( NRF-2021M3E5D9025022 and 2018R1A2B2007714 to SJ Kim). The funding source did not influence the study design, data collection, analysis and interpretation of data, writing of the report, or decision to submit the article for publication. Publisher Copyright: {\textcopyright} 2023",

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AU - Chang, Won Seok

AU - Kim, Chan Hyung

AU - Kim, Se Joo

AU - Chang, Jin Woo

N1 - Funding Information: This study was supported by the Focused Ultrasound Foundation (Charlottesville, VA, USA). The sponsor played no role in the study design, data collection, data analysis, data interpretation, writing of the report, or decision to submit the paper for publication. JWC had full access to all the data associated with this research and had the final responsibility for deciding to submit this manuscript for publication. Funding Information: This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government ( NRF-2021M3E5D9025022 and 2018R1A2B2007714 to SJ Kim). The funding source did not influence the study design, data collection, analysis and interpretation of data, writing of the report, or decision to submit the article for publication. Publisher Copyright: © 2023

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N2 - Bilateral thermal capsulotomy with magnetic resonance-guided focused ultrasound (MRgFUS-capsulotomy) is a promising treatment option for treatment-refractory obsessive-compulsive disorder (OCD). Herein, we investigated the effects of bilateral thermal capsulotomy with MRgFUS on neural oscillations in treatment-refractory OCD patients. Eight patients underwent resting-state MEG with repeated recordings before and 1 and 6 months after MRgFUS-capsulotomy, and the oscillatory power and phase coherence over the entire cortical sensor area were measured. After MRgFUS-capsulotomy, the high beta band power in the fronto-central and temporal areas decreased at 1 month and remained stable for 6 months. Cortical connectivity of the high beta band gradually decreased over the entire cortical area during the following 6 months. At 1 month, improvement in anxiety and depression symptoms was significantly correlated with changes in high beta band power in both the frontotemporal and temporal areas. The treatment effect of MRgFUS-capsulotomy may be attributed to the cortical high beta band. Our results provide an advanced understanding of the neural mechanisms underlying MRgFUS-capsulotomy and other neuromodulatory interventions for treatment-refractory OCD.

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Evaluation of changes in neural oscillation after bilateral capsulotomy in treatment refractory obsessive-compulsive disorder using magnetoencephalogram

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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