Evaluation of metabolic syndrome risk in Korean premenopausal women - Not waist circumference but visceral fat

Yae Jung Hyun, Oh Yoen Kim, Yangsoo Jang, Jong Won Ha, Jey Sook Chae, Ji Young Kim, Hyun Yang Yeo, Jean Kyung Paik, Jong Ho Lee

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38 Citations (Scopus)

Abstract

Background: In clinical practice, using the patient's waist circumference (WC) to evaluate visceral obesity may underestimate disorders with a metabolic origin. This study examined whether or not the WC derived from the cut-off point of the visceral fat area (VFA) can reflect the features of metabolic syndrome (MetS) in premenopausal women. Methods and Results: Computed tomography-scanned VFA, MetS components and the concentrations of high-sensitivity C-reactive protein (CRP) and adiponectin were measured in a total of 349 premenopausal women. The VFA at the L1 and the L4 sites was a significant index (p<0.001) of incremental MetS risk. Receiver-operating characteristic curve analysis showed that 75 cm2 of VFA at L4 and 87.5 cm2 at L1 were the optimal thresholds for discrimination of MetS risk. Significant differences in all MetS components, as well as CRP (p<0.05) and adiponectin levels (p<0.005), were observed when subjects were subdivided by the L4 VFA cut-off point (<75/ ≥75 cm2), whereas there was a significant difference only in the triglycerides level in the groups divided by WC (WC <88/≥88 cm). Moreover, subjects with a lower WC-higher VFA showed a similar pattern in MetS components and lower adiponectin than those with a higher WC-higher VFA. Conclusions: This study clarified that VFA rather than WC is a major determinant of MetS risk in premenopausal women.

Original languageEnglish
Pages (from-to)1308-1315
Number of pages8
JournalCirculation Journal
Volume72
Issue number8
DOIs
Publication statusPublished - 2008 Aug 11

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Intra-Abdominal Fat
Waist Circumference
Adiponectin
C-Reactive Protein
Abdominal Obesity
ROC Curve
Triglycerides
Tomography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hyun, Yae Jung ; Kim, Oh Yoen ; Jang, Yangsoo ; Ha, Jong Won ; Chae, Jey Sook ; Kim, Ji Young ; Yeo, Hyun Yang ; Paik, Jean Kyung ; Lee, Jong Ho. / Evaluation of metabolic syndrome risk in Korean premenopausal women - Not waist circumference but visceral fat. In: Circulation Journal. 2008 ; Vol. 72, No. 8. pp. 1308-1315.
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abstract = "Background: In clinical practice, using the patient's waist circumference (WC) to evaluate visceral obesity may underestimate disorders with a metabolic origin. This study examined whether or not the WC derived from the cut-off point of the visceral fat area (VFA) can reflect the features of metabolic syndrome (MetS) in premenopausal women. Methods and Results: Computed tomography-scanned VFA, MetS components and the concentrations of high-sensitivity C-reactive protein (CRP) and adiponectin were measured in a total of 349 premenopausal women. The VFA at the L1 and the L4 sites was a significant index (p<0.001) of incremental MetS risk. Receiver-operating characteristic curve analysis showed that 75 cm2 of VFA at L4 and 87.5 cm2 at L1 were the optimal thresholds for discrimination of MetS risk. Significant differences in all MetS components, as well as CRP (p<0.05) and adiponectin levels (p<0.005), were observed when subjects were subdivided by the L4 VFA cut-off point (<75/ ≥75 cm2), whereas there was a significant difference only in the triglycerides level in the groups divided by WC (WC <88/≥88 cm). Moreover, subjects with a lower WC-higher VFA showed a similar pattern in MetS components and lower adiponectin than those with a higher WC-higher VFA. Conclusions: This study clarified that VFA rather than WC is a major determinant of MetS risk in premenopausal women.",
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Evaluation of metabolic syndrome risk in Korean premenopausal women - Not waist circumference but visceral fat. / Hyun, Yae Jung; Kim, Oh Yoen; Jang, Yangsoo; Ha, Jong Won; Chae, Jey Sook; Kim, Ji Young; Yeo, Hyun Yang; Paik, Jean Kyung; Lee, Jong Ho.

In: Circulation Journal, Vol. 72, No. 8, 11.08.2008, p. 1308-1315.

Research output: Contribution to journalArticle

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T1 - Evaluation of metabolic syndrome risk in Korean premenopausal women - Not waist circumference but visceral fat

AU - Hyun, Yae Jung

AU - Kim, Oh Yoen

AU - Jang, Yangsoo

AU - Ha, Jong Won

AU - Chae, Jey Sook

AU - Kim, Ji Young

AU - Yeo, Hyun Yang

AU - Paik, Jean Kyung

AU - Lee, Jong Ho

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N2 - Background: In clinical practice, using the patient's waist circumference (WC) to evaluate visceral obesity may underestimate disorders with a metabolic origin. This study examined whether or not the WC derived from the cut-off point of the visceral fat area (VFA) can reflect the features of metabolic syndrome (MetS) in premenopausal women. Methods and Results: Computed tomography-scanned VFA, MetS components and the concentrations of high-sensitivity C-reactive protein (CRP) and adiponectin were measured in a total of 349 premenopausal women. The VFA at the L1 and the L4 sites was a significant index (p<0.001) of incremental MetS risk. Receiver-operating characteristic curve analysis showed that 75 cm2 of VFA at L4 and 87.5 cm2 at L1 were the optimal thresholds for discrimination of MetS risk. Significant differences in all MetS components, as well as CRP (p<0.05) and adiponectin levels (p<0.005), were observed when subjects were subdivided by the L4 VFA cut-off point (<75/ ≥75 cm2), whereas there was a significant difference only in the triglycerides level in the groups divided by WC (WC <88/≥88 cm). Moreover, subjects with a lower WC-higher VFA showed a similar pattern in MetS components and lower adiponectin than those with a higher WC-higher VFA. Conclusions: This study clarified that VFA rather than WC is a major determinant of MetS risk in premenopausal women.

AB - Background: In clinical practice, using the patient's waist circumference (WC) to evaluate visceral obesity may underestimate disorders with a metabolic origin. This study examined whether or not the WC derived from the cut-off point of the visceral fat area (VFA) can reflect the features of metabolic syndrome (MetS) in premenopausal women. Methods and Results: Computed tomography-scanned VFA, MetS components and the concentrations of high-sensitivity C-reactive protein (CRP) and adiponectin were measured in a total of 349 premenopausal women. The VFA at the L1 and the L4 sites was a significant index (p<0.001) of incremental MetS risk. Receiver-operating characteristic curve analysis showed that 75 cm2 of VFA at L4 and 87.5 cm2 at L1 were the optimal thresholds for discrimination of MetS risk. Significant differences in all MetS components, as well as CRP (p<0.05) and adiponectin levels (p<0.005), were observed when subjects were subdivided by the L4 VFA cut-off point (<75/ ≥75 cm2), whereas there was a significant difference only in the triglycerides level in the groups divided by WC (WC <88/≥88 cm). Moreover, subjects with a lower WC-higher VFA showed a similar pattern in MetS components and lower adiponectin than those with a higher WC-higher VFA. Conclusions: This study clarified that VFA rather than WC is a major determinant of MetS risk in premenopausal women.

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