Evaluation of new hemagglutinin-based rapid antigen test for influenza A pandemic (H1N1) 2009

Young Keun Kim, Young Uh, Jin Kyong Chun, Changsoo Kim, Hyo Youl Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: A new rapid antigen test (RAT), based on hemagglutinin, was developed for the improvement of influenza A pandemic (H1N1) 2009 detection. Objective: To evaluate the performance of the new RAT for the diagnosis of influenza A pandemic (H1N1) 2009. Study design: The new RAT included 2009 H1N1 hemagglutinin-based band and influenza A and influenza B nucleoprotein-based bands. During the period from November 24, 2009 to December 14, 2009, 948 patients underwent the new RAT and real-time reverse transcriptase polymerase chain reaction (rRT-PCR) at the same time. The result of the new RAT was compared with that of rRT-PCR, and the results of hemagglutinin-based and nucleoprotein-based antigen tests were compared. Result: Among the 260 patients confirmed by rRT-PCR, 153 (58.8%) were positive in the nucleoprotein-based antigen test, and 182 (70.0%) were positive in the hemagglutinin-based antigen test. These results show that the new hemagglutinin-based antigen test was more sensitive than the nucleoprotein-based antigen test for the detection of influenza A pandemic (H1N1) 2009 (p< 0.001, the McNemar test). Conclusion: The new hemagglutinin-based antigen test improved the sensitivity of diagnosis for influenza A pandemic (H1N1) 2009 and it might be helpful for the diagnosis of influenza A pandemic (H1N1) 2009.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalJournal of Clinical Virology
Volume49
Issue number1
DOIs
Publication statusPublished - 2010 Sep 1

Fingerprint

Hemagglutinins
Pandemics
Human Influenza
Antigens
Nucleoproteins
Reverse Transcriptase Polymerase Chain Reaction
Real-Time Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

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title = "Evaluation of new hemagglutinin-based rapid antigen test for influenza A pandemic (H1N1) 2009",
abstract = "Background: A new rapid antigen test (RAT), based on hemagglutinin, was developed for the improvement of influenza A pandemic (H1N1) 2009 detection. Objective: To evaluate the performance of the new RAT for the diagnosis of influenza A pandemic (H1N1) 2009. Study design: The new RAT included 2009 H1N1 hemagglutinin-based band and influenza A and influenza B nucleoprotein-based bands. During the period from November 24, 2009 to December 14, 2009, 948 patients underwent the new RAT and real-time reverse transcriptase polymerase chain reaction (rRT-PCR) at the same time. The result of the new RAT was compared with that of rRT-PCR, and the results of hemagglutinin-based and nucleoprotein-based antigen tests were compared. Result: Among the 260 patients confirmed by rRT-PCR, 153 (58.8{\%}) were positive in the nucleoprotein-based antigen test, and 182 (70.0{\%}) were positive in the hemagglutinin-based antigen test. These results show that the new hemagglutinin-based antigen test was more sensitive than the nucleoprotein-based antigen test for the detection of influenza A pandemic (H1N1) 2009 (p< 0.001, the McNemar test). Conclusion: The new hemagglutinin-based antigen test improved the sensitivity of diagnosis for influenza A pandemic (H1N1) 2009 and it might be helpful for the diagnosis of influenza A pandemic (H1N1) 2009.",
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Evaluation of new hemagglutinin-based rapid antigen test for influenza A pandemic (H1N1) 2009. / Kim, Young Keun; Uh, Young; Chun, Jin Kyong; Kim, Changsoo; Kim, Hyo Youl.

In: Journal of Clinical Virology, Vol. 49, No. 1, 01.09.2010, p. 69-72.

Research output: Contribution to journalArticle

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