Evaluation of nitroglycerin and cyclosporin A sorption to polyvinylchloride- and non-polyvinylchloride-based tubes in administration sets

Su Eon Jin, Jung Woo Park, Hong Baek, Seungho Jeon, Sang Wook Park, Sung Joo Hwang

Research output: Contribution to journalArticle

Abstract

We report the sorption evaluation method for injectable drugs administered using set tubes to evaluate the quality of the administration sets. The evaluation method using a peristaltic pump, so called pump method, was used for the kinetic sorption study. Nitroglycerin (NTG) and cyclosporin A (CSA) were selected as model drugs. The parameters of drug-diluted concentrations and flow rates were adapted to the clinically relevant values. Polyvinylchloride (PVC)- and non-PVC (PU and PO)-based tubes were cut to a fixed length of 1 m after removing the accessories in the administration sets. NTG and CSA were analyzed using high-performance liquid chromatography (HPLC) methods with ultraviolet (UV) detection. After the drug analyses, NTG and CSA sorption levels were calculated from the percentage values of the subtracted drug concentrations in samples from those in the diluted solutions. The average sorption levels and each sorption level at each sampling point were considered to compare the sorption levels in all administration set tubes. Both drugs showed high sorption levels in PVC- and PU-based administration set tubes. However, the drugs showed a minimum sorption potential of < 10% on PO-based tubes, which could be clinically acceptable. This suggests that the sorption evaluation methods for NTG and CSA could be promising standards for endorsing administration set tubes and for evaluating newly developed or designed polymeric alternatives. Additionally, PO could be an alternative and next-generation polymeric material for manufacturing administration set tubes.

Original languageEnglish
Pages (from-to)665-672
Number of pages8
JournalJournal of Pharmaceutical Investigation
Volume48
Issue number6
DOIs
Publication statusPublished - 2018 Nov 15

Fingerprint

Nitroglycerin
Cyclosporine
Pharmaceutical Preparations
High Pressure Liquid Chromatography
Injections

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cite this

@article{f834dacdfbf14a67bcb82b07d0852163,
title = "Evaluation of nitroglycerin and cyclosporin A sorption to polyvinylchloride- and non-polyvinylchloride-based tubes in administration sets",
abstract = "We report the sorption evaluation method for injectable drugs administered using set tubes to evaluate the quality of the administration sets. The evaluation method using a peristaltic pump, so called pump method, was used for the kinetic sorption study. Nitroglycerin (NTG) and cyclosporin A (CSA) were selected as model drugs. The parameters of drug-diluted concentrations and flow rates were adapted to the clinically relevant values. Polyvinylchloride (PVC)- and non-PVC (PU and PO)-based tubes were cut to a fixed length of 1 m after removing the accessories in the administration sets. NTG and CSA were analyzed using high-performance liquid chromatography (HPLC) methods with ultraviolet (UV) detection. After the drug analyses, NTG and CSA sorption levels were calculated from the percentage values of the subtracted drug concentrations in samples from those in the diluted solutions. The average sorption levels and each sorption level at each sampling point were considered to compare the sorption levels in all administration set tubes. Both drugs showed high sorption levels in PVC- and PU-based administration set tubes. However, the drugs showed a minimum sorption potential of < 10{\%} on PO-based tubes, which could be clinically acceptable. This suggests that the sorption evaluation methods for NTG and CSA could be promising standards for endorsing administration set tubes and for evaluating newly developed or designed polymeric alternatives. Additionally, PO could be an alternative and next-generation polymeric material for manufacturing administration set tubes.",
author = "Jin, {Su Eon} and Park, {Jung Woo} and Hong Baek and Seungho Jeon and Park, {Sang Wook} and Hwang, {Sung Joo}",
year = "2018",
month = "11",
day = "15",
doi = "10.1007/s40005-017-0364-2",
language = "English",
volume = "48",
pages = "665--672",
journal = "Journal of Pharmaceutical Investigation",
issn = "2093-5552",
publisher = "Springer Netherlands",
number = "6",

}

Evaluation of nitroglycerin and cyclosporin A sorption to polyvinylchloride- and non-polyvinylchloride-based tubes in administration sets. / Jin, Su Eon; Park, Jung Woo; Baek, Hong; Jeon, Seungho; Park, Sang Wook; Hwang, Sung Joo.

In: Journal of Pharmaceutical Investigation, Vol. 48, No. 6, 15.11.2018, p. 665-672.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of nitroglycerin and cyclosporin A sorption to polyvinylchloride- and non-polyvinylchloride-based tubes in administration sets

AU - Jin, Su Eon

AU - Park, Jung Woo

AU - Baek, Hong

AU - Jeon, Seungho

AU - Park, Sang Wook

AU - Hwang, Sung Joo

PY - 2018/11/15

Y1 - 2018/11/15

N2 - We report the sorption evaluation method for injectable drugs administered using set tubes to evaluate the quality of the administration sets. The evaluation method using a peristaltic pump, so called pump method, was used for the kinetic sorption study. Nitroglycerin (NTG) and cyclosporin A (CSA) were selected as model drugs. The parameters of drug-diluted concentrations and flow rates were adapted to the clinically relevant values. Polyvinylchloride (PVC)- and non-PVC (PU and PO)-based tubes were cut to a fixed length of 1 m after removing the accessories in the administration sets. NTG and CSA were analyzed using high-performance liquid chromatography (HPLC) methods with ultraviolet (UV) detection. After the drug analyses, NTG and CSA sorption levels were calculated from the percentage values of the subtracted drug concentrations in samples from those in the diluted solutions. The average sorption levels and each sorption level at each sampling point were considered to compare the sorption levels in all administration set tubes. Both drugs showed high sorption levels in PVC- and PU-based administration set tubes. However, the drugs showed a minimum sorption potential of < 10% on PO-based tubes, which could be clinically acceptable. This suggests that the sorption evaluation methods for NTG and CSA could be promising standards for endorsing administration set tubes and for evaluating newly developed or designed polymeric alternatives. Additionally, PO could be an alternative and next-generation polymeric material for manufacturing administration set tubes.

AB - We report the sorption evaluation method for injectable drugs administered using set tubes to evaluate the quality of the administration sets. The evaluation method using a peristaltic pump, so called pump method, was used for the kinetic sorption study. Nitroglycerin (NTG) and cyclosporin A (CSA) were selected as model drugs. The parameters of drug-diluted concentrations and flow rates were adapted to the clinically relevant values. Polyvinylchloride (PVC)- and non-PVC (PU and PO)-based tubes were cut to a fixed length of 1 m after removing the accessories in the administration sets. NTG and CSA were analyzed using high-performance liquid chromatography (HPLC) methods with ultraviolet (UV) detection. After the drug analyses, NTG and CSA sorption levels were calculated from the percentage values of the subtracted drug concentrations in samples from those in the diluted solutions. The average sorption levels and each sorption level at each sampling point were considered to compare the sorption levels in all administration set tubes. Both drugs showed high sorption levels in PVC- and PU-based administration set tubes. However, the drugs showed a minimum sorption potential of < 10% on PO-based tubes, which could be clinically acceptable. This suggests that the sorption evaluation methods for NTG and CSA could be promising standards for endorsing administration set tubes and for evaluating newly developed or designed polymeric alternatives. Additionally, PO could be an alternative and next-generation polymeric material for manufacturing administration set tubes.

UR - http://www.scopus.com/inward/record.url?scp=85055124029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055124029&partnerID=8YFLogxK

U2 - 10.1007/s40005-017-0364-2

DO - 10.1007/s40005-017-0364-2

M3 - Article

AN - SCOPUS:85055124029

VL - 48

SP - 665

EP - 672

JO - Journal of Pharmaceutical Investigation

JF - Journal of Pharmaceutical Investigation

SN - 2093-5552

IS - 6

ER -