Evaluation of outcome of delayed neurologic sequelae after carbon monoxide poisoning by technetium-99m hexamethyl- propylene amine oxime brain single photon emission computed tomography

H. Saing Choi, Soon Kwan, Kim Sung, Soo Lee, Young Chul Choi

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28 Citations (Scopus)

Abstract

Using brain computed tomography (CT) and single photon emission computed tomography (SPECT) with technetium-99m hexamethylpropylene amine oxime (99mTc HM-PAO) in 13 patients with delayed neurologic sequelae after carbon monoxide poisoning, we tried to evaluate the clinical outcome of delayed CO sequelae. Among the 13 initial brain CTs, seven showed low density in the cerebral white matter and one revealed hypodensity in both globi pallidi. Of the 7 follow-up CT scans, 3 have remained unchanged, but in cases more aggravating patterns with cortical atrophy without the clinical correlation were observed. There was no correlation between the CT findings and the outcome of delayed CO sequelae. All initial SPECTs in 13 patients with delayed CO sequelae showed diffuse patchy hypoperfusion throughout the cerebral cortex. Among the follow-up SPECTs in 7 patients, 6 patients showed increased cerebral perfusion with the concomitant clinical improvement, but the SPECT of a patient in bedridden state had remained unchanged, compared with the initial SPECT. There seemed to be good correlation between the findings of SPECT and the outcome of delayed CO sequelae. In conclusion,99m Tc HM-PAO brain SPECT is more sensitive than CT, and may be a useful test in evaluating the clinical outcome of delayed neurologic sequelae after CO poisoning.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalEuropean Neurology
Volume35
Issue number3
DOIs
Publication statusPublished - 1995 Jan 1

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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