Evaluation of quantitative accuracy in CZT-based pre-clinical SPECT for various isotopes

S. J. Park, A. R. Yu, Y. S. Kim, W. S. Kang, Jinsuck Suh, J. S. Kim, T. J. Son, H. J. Kim

Research output: Contribution to journalArticle

Abstract

In vivo pre-clinical single-photon emission computed tomography (SPECT) is a valuable tool for functional small animal imaging, but several physical factors, such as scatter radiation, limit the quantitative accuracy of conventional scintillation crystal-based SPECT. Semiconductor detectors such as CZT overcome these deficiencies through superior energy resolution. To our knowledge, little scientific information exists regarding the accuracy of quantitative analysis in CZT-based pre-clinical SPECT systems for different isotopes. The aim of this study was to assess the quantitative accuracy of CZT-based pre-clinical SPECT for four isotopes: 201 Tl, 99m Tc, 123 I, and 111 In. The quantitative accuracy of the CZT-based Triumph X-SPECT (Gamma-Medica Ideas, Northridge, CA, U.S.A.) was compared with that of a conventional SPECT using GATE simulation. Quantitative errors due to the attenuation and scatter effects were evaluated for all four isotopes with energy windows of 5%, 10%, and 20%. A spherical source containing the isotope was placed at the center of the air-or-water-filled mouse-sized cylinder phantom. The CZT-based pre-clinical SPECT was more accurate than the conventional SPECT. For example, in the conventional SPECT with an energy window of 10%, scatter effects degraded quantitative accuracy by up to 11.52%, 5.10%, 2.88%, and 1.84% for 201 Tl, 99m Tc, 123 I, and 111 In, respectively. However, with the CZT-based pre-clinical SPECT, the degradations were only 9.67%, 5.45%, 2.36%, and 1.24% for 201 Tl, 99m Tc, 123 I, and 111 In, respectively. As the energy window was increased, the quantitative errors increased in both SPECT systems. Additionally, the isotopes with lower energy of photon emissions had greater quantitative error. Our results demonstrated that the CZT-based pre-clinical SPECT had lower overall quantitative errors due to reduced scatter and high detection efficiency. Furthermore, the results of this systematic assessment quantifying the accuracy of these SPECT for various isotopes will provide valuable reference information for the design of CZT-based pre-clinical SPECT system imaging protocols. andcopy; 2015 IOP Publishing Ltd and Sissa Medialab srl.

Original languageEnglish
Article numberT05004
JournalJournal of Instrumentation
Volume10
Issue number5
DOIs
Publication statusPublished - 2015 May 1

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Single photon emission computed tomography
Computed Tomography
Isotopes
Photon
isotopes
tomography
evaluation
photons
Evaluation
Scatter
Energy
energy
Semiconductor detectors
GARP Atlantic Tropical Experiment
physical factors
Scintillation

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Mathematical Physics

Cite this

Park, S. J. ; Yu, A. R. ; Kim, Y. S. ; Kang, W. S. ; Suh, Jinsuck ; Kim, J. S. ; Son, T. J. ; Kim, H. J. / Evaluation of quantitative accuracy in CZT-based pre-clinical SPECT for various isotopes. In: Journal of Instrumentation. 2015 ; Vol. 10, No. 5.
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abstract = "In vivo pre-clinical single-photon emission computed tomography (SPECT) is a valuable tool for functional small animal imaging, but several physical factors, such as scatter radiation, limit the quantitative accuracy of conventional scintillation crystal-based SPECT. Semiconductor detectors such as CZT overcome these deficiencies through superior energy resolution. To our knowledge, little scientific information exists regarding the accuracy of quantitative analysis in CZT-based pre-clinical SPECT systems for different isotopes. The aim of this study was to assess the quantitative accuracy of CZT-based pre-clinical SPECT for four isotopes: 201 Tl, 99m Tc, 123 I, and 111 In. The quantitative accuracy of the CZT-based Triumph X-SPECT (Gamma-Medica Ideas, Northridge, CA, U.S.A.) was compared with that of a conventional SPECT using GATE simulation. Quantitative errors due to the attenuation and scatter effects were evaluated for all four isotopes with energy windows of 5{\%}, 10{\%}, and 20{\%}. A spherical source containing the isotope was placed at the center of the air-or-water-filled mouse-sized cylinder phantom. The CZT-based pre-clinical SPECT was more accurate than the conventional SPECT. For example, in the conventional SPECT with an energy window of 10{\%}, scatter effects degraded quantitative accuracy by up to 11.52{\%}, 5.10{\%}, 2.88{\%}, and 1.84{\%} for 201 Tl, 99m Tc, 123 I, and 111 In, respectively. However, with the CZT-based pre-clinical SPECT, the degradations were only 9.67{\%}, 5.45{\%}, 2.36{\%}, and 1.24{\%} for 201 Tl, 99m Tc, 123 I, and 111 In, respectively. As the energy window was increased, the quantitative errors increased in both SPECT systems. Additionally, the isotopes with lower energy of photon emissions had greater quantitative error. Our results demonstrated that the CZT-based pre-clinical SPECT had lower overall quantitative errors due to reduced scatter and high detection efficiency. Furthermore, the results of this systematic assessment quantifying the accuracy of these SPECT for various isotopes will provide valuable reference information for the design of CZT-based pre-clinical SPECT system imaging protocols. andcopy; 2015 IOP Publishing Ltd and Sissa Medialab srl.",
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Evaluation of quantitative accuracy in CZT-based pre-clinical SPECT for various isotopes. / Park, S. J.; Yu, A. R.; Kim, Y. S.; Kang, W. S.; Suh, Jinsuck; Kim, J. S.; Son, T. J.; Kim, H. J.

In: Journal of Instrumentation, Vol. 10, No. 5, T05004, 01.05.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of quantitative accuracy in CZT-based pre-clinical SPECT for various isotopes

AU - Park, S. J.

AU - Yu, A. R.

AU - Kim, Y. S.

AU - Kang, W. S.

AU - Suh, Jinsuck

AU - Kim, J. S.

AU - Son, T. J.

AU - Kim, H. J.

PY - 2015/5/1

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N2 - In vivo pre-clinical single-photon emission computed tomography (SPECT) is a valuable tool for functional small animal imaging, but several physical factors, such as scatter radiation, limit the quantitative accuracy of conventional scintillation crystal-based SPECT. Semiconductor detectors such as CZT overcome these deficiencies through superior energy resolution. To our knowledge, little scientific information exists regarding the accuracy of quantitative analysis in CZT-based pre-clinical SPECT systems for different isotopes. The aim of this study was to assess the quantitative accuracy of CZT-based pre-clinical SPECT for four isotopes: 201 Tl, 99m Tc, 123 I, and 111 In. The quantitative accuracy of the CZT-based Triumph X-SPECT (Gamma-Medica Ideas, Northridge, CA, U.S.A.) was compared with that of a conventional SPECT using GATE simulation. Quantitative errors due to the attenuation and scatter effects were evaluated for all four isotopes with energy windows of 5%, 10%, and 20%. A spherical source containing the isotope was placed at the center of the air-or-water-filled mouse-sized cylinder phantom. The CZT-based pre-clinical SPECT was more accurate than the conventional SPECT. For example, in the conventional SPECT with an energy window of 10%, scatter effects degraded quantitative accuracy by up to 11.52%, 5.10%, 2.88%, and 1.84% for 201 Tl, 99m Tc, 123 I, and 111 In, respectively. However, with the CZT-based pre-clinical SPECT, the degradations were only 9.67%, 5.45%, 2.36%, and 1.24% for 201 Tl, 99m Tc, 123 I, and 111 In, respectively. As the energy window was increased, the quantitative errors increased in both SPECT systems. Additionally, the isotopes with lower energy of photon emissions had greater quantitative error. Our results demonstrated that the CZT-based pre-clinical SPECT had lower overall quantitative errors due to reduced scatter and high detection efficiency. Furthermore, the results of this systematic assessment quantifying the accuracy of these SPECT for various isotopes will provide valuable reference information for the design of CZT-based pre-clinical SPECT system imaging protocols. andcopy; 2015 IOP Publishing Ltd and Sissa Medialab srl.

AB - In vivo pre-clinical single-photon emission computed tomography (SPECT) is a valuable tool for functional small animal imaging, but several physical factors, such as scatter radiation, limit the quantitative accuracy of conventional scintillation crystal-based SPECT. Semiconductor detectors such as CZT overcome these deficiencies through superior energy resolution. To our knowledge, little scientific information exists regarding the accuracy of quantitative analysis in CZT-based pre-clinical SPECT systems for different isotopes. The aim of this study was to assess the quantitative accuracy of CZT-based pre-clinical SPECT for four isotopes: 201 Tl, 99m Tc, 123 I, and 111 In. The quantitative accuracy of the CZT-based Triumph X-SPECT (Gamma-Medica Ideas, Northridge, CA, U.S.A.) was compared with that of a conventional SPECT using GATE simulation. Quantitative errors due to the attenuation and scatter effects were evaluated for all four isotopes with energy windows of 5%, 10%, and 20%. A spherical source containing the isotope was placed at the center of the air-or-water-filled mouse-sized cylinder phantom. The CZT-based pre-clinical SPECT was more accurate than the conventional SPECT. For example, in the conventional SPECT with an energy window of 10%, scatter effects degraded quantitative accuracy by up to 11.52%, 5.10%, 2.88%, and 1.84% for 201 Tl, 99m Tc, 123 I, and 111 In, respectively. However, with the CZT-based pre-clinical SPECT, the degradations were only 9.67%, 5.45%, 2.36%, and 1.24% for 201 Tl, 99m Tc, 123 I, and 111 In, respectively. As the energy window was increased, the quantitative errors increased in both SPECT systems. Additionally, the isotopes with lower energy of photon emissions had greater quantitative error. Our results demonstrated that the CZT-based pre-clinical SPECT had lower overall quantitative errors due to reduced scatter and high detection efficiency. Furthermore, the results of this systematic assessment quantifying the accuracy of these SPECT for various isotopes will provide valuable reference information for the design of CZT-based pre-clinical SPECT system imaging protocols. andcopy; 2015 IOP Publishing Ltd and Sissa Medialab srl.

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