Abstract
Problem: The aim of this study was to evaluate serum and urinary levels of vascular endothelial growth factors, tumor necrosis factor-α (TNF-α), and soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis. Method of study: During surgery for pelvic pain, pelvic mass or infertility, serum and urine were collected. Of 70 patients, 46 had histology-proven endometriosis and 24 patients without endometriosis participated as controls. Results: Serum TNF-α levels and urinarysFlt-1 levels corrected for creatinine excretion were significantly increased in the endometriosis group (P = 0.001 and P = 0.011 respectively). Serum sFlt-1 levels and urinary sFlt-1 levels corrected for creatinine were significantly higher in patients with minimal-to-mild disease (P = 0.014 and P = 0.015 respectively), where serum TNF-α levels were increased in moderate-to-severe endometriosis (P < 0.001). Conclusion: The pathogenesis of minimal-to-mild endometriosis and moderate-to-severe endometriosis seems to be different. Increased sFlt-1 levels in serum and urine of minimal-to-mild disease indicate that sFlt-1 may have an important role in inhibiting angiogenic process of the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 497-504 |
| Number of pages | 8 |
| Journal | American Journal of Reproductive Immunology |
| Volume | 58 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2007 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Reproductive Medicine
- Obstetrics and Gynaecology
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Evaluation of serum and urinary angiogenic factors in patients with endometriosis. / Cho, Si Hyun; Oh, Yoon Jin; Nam, Anna; Kim, Hye Yeon; Park, Joo Hyun; Kim, Jae-Hoon; Park, Ki Hyun; Cho, Dong Je; Lee, Byung Seok.
In: American Journal of Reproductive Immunology, Vol. 58, No. 6, 01.12.2007, p. 497-504.Research output: Contribution to journal › Article
TY - JOUR
T1 - Evaluation of serum and urinary angiogenic factors in patients with endometriosis
AU - Cho, Si Hyun
AU - Oh, Yoon Jin
AU - Nam, Anna
AU - Kim, Hye Yeon
AU - Park, Joo Hyun
AU - Kim, Jae-Hoon
AU - Park, Ki Hyun
AU - Cho, Dong Je
AU - Lee, Byung Seok
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Problem: The aim of this study was to evaluate serum and urinary levels of vascular endothelial growth factors, tumor necrosis factor-α (TNF-α), and soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis. Method of study: During surgery for pelvic pain, pelvic mass or infertility, serum and urine were collected. Of 70 patients, 46 had histology-proven endometriosis and 24 patients without endometriosis participated as controls. Results: Serum TNF-α levels and urinarysFlt-1 levels corrected for creatinine excretion were significantly increased in the endometriosis group (P = 0.001 and P = 0.011 respectively). Serum sFlt-1 levels and urinary sFlt-1 levels corrected for creatinine were significantly higher in patients with minimal-to-mild disease (P = 0.014 and P = 0.015 respectively), where serum TNF-α levels were increased in moderate-to-severe endometriosis (P < 0.001). Conclusion: The pathogenesis of minimal-to-mild endometriosis and moderate-to-severe endometriosis seems to be different. Increased sFlt-1 levels in serum and urine of minimal-to-mild disease indicate that sFlt-1 may have an important role in inhibiting angiogenic process of the disease.
AB - Problem: The aim of this study was to evaluate serum and urinary levels of vascular endothelial growth factors, tumor necrosis factor-α (TNF-α), and soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis. Method of study: During surgery for pelvic pain, pelvic mass or infertility, serum and urine were collected. Of 70 patients, 46 had histology-proven endometriosis and 24 patients without endometriosis participated as controls. Results: Serum TNF-α levels and urinarysFlt-1 levels corrected for creatinine excretion were significantly increased in the endometriosis group (P = 0.001 and P = 0.011 respectively). Serum sFlt-1 levels and urinary sFlt-1 levels corrected for creatinine were significantly higher in patients with minimal-to-mild disease (P = 0.014 and P = 0.015 respectively), where serum TNF-α levels were increased in moderate-to-severe endometriosis (P < 0.001). Conclusion: The pathogenesis of minimal-to-mild endometriosis and moderate-to-severe endometriosis seems to be different. Increased sFlt-1 levels in serum and urine of minimal-to-mild disease indicate that sFlt-1 may have an important role in inhibiting angiogenic process of the disease.
UR - http://www.scopus.com/inward/record.url?scp=36048993203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36048993203&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.2007.00535.x
DO - 10.1111/j.1600-0897.2007.00535.x
M3 - Article
C2 - 17997748
AN - SCOPUS:36048993203
VL - 58
SP - 497
EP - 504
JO - American Journal of Reproductive Immunology and Microbiology
JF - American Journal of Reproductive Immunology and Microbiology
SN - 1046-7408
IS - 6
ER -