Evaluation of serum and urinary angiogenic factors in patients with endometriosis

Si Hyun Cho, Yoon Jin Oh, Anna Nam, Hye Yeon Kim, Joo Hyun Park, Jae-Hoon Kim, Ki Hyun Park, Dong Je Cho, Byung Seok Lee

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Problem: The aim of this study was to evaluate serum and urinary levels of vascular endothelial growth factors, tumor necrosis factor-α (TNF-α), and soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis. Method of study: During surgery for pelvic pain, pelvic mass or infertility, serum and urine were collected. Of 70 patients, 46 had histology-proven endometriosis and 24 patients without endometriosis participated as controls. Results: Serum TNF-α levels and urinarysFlt-1 levels corrected for creatinine excretion were significantly increased in the endometriosis group (P = 0.001 and P = 0.011 respectively). Serum sFlt-1 levels and urinary sFlt-1 levels corrected for creatinine were significantly higher in patients with minimal-to-mild disease (P = 0.014 and P = 0.015 respectively), where serum TNF-α levels were increased in moderate-to-severe endometriosis (P < 0.001). Conclusion: The pathogenesis of minimal-to-mild endometriosis and moderate-to-severe endometriosis seems to be different. Increased sFlt-1 levels in serum and urine of minimal-to-mild disease indicate that sFlt-1 may have an important role in inhibiting angiogenic process of the disease.

Original languageEnglish
Pages (from-to)497-504
Number of pages8
JournalAmerican Journal of Reproductive Immunology
Volume58
Issue number6
DOIs
Publication statusPublished - 2007 Dec 1

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Angiogenesis Inducing Agents
Endometriosis
Serum
Tumor Necrosis Factor-alpha
Creatinine
Vascular Endothelial Growth Factors
Urine
Vascular Endothelial Growth Factor Receptor-1
Pelvic Pain
Infertility
Histology

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Cho, Si Hyun ; Oh, Yoon Jin ; Nam, Anna ; Kim, Hye Yeon ; Park, Joo Hyun ; Kim, Jae-Hoon ; Park, Ki Hyun ; Cho, Dong Je ; Lee, Byung Seok. / Evaluation of serum and urinary angiogenic factors in patients with endometriosis. In: American Journal of Reproductive Immunology. 2007 ; Vol. 58, No. 6. pp. 497-504.
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abstract = "Problem: The aim of this study was to evaluate serum and urinary levels of vascular endothelial growth factors, tumor necrosis factor-α (TNF-α), and soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis. Method of study: During surgery for pelvic pain, pelvic mass or infertility, serum and urine were collected. Of 70 patients, 46 had histology-proven endometriosis and 24 patients without endometriosis participated as controls. Results: Serum TNF-α levels and urinarysFlt-1 levels corrected for creatinine excretion were significantly increased in the endometriosis group (P = 0.001 and P = 0.011 respectively). Serum sFlt-1 levels and urinary sFlt-1 levels corrected for creatinine were significantly higher in patients with minimal-to-mild disease (P = 0.014 and P = 0.015 respectively), where serum TNF-α levels were increased in moderate-to-severe endometriosis (P < 0.001). Conclusion: The pathogenesis of minimal-to-mild endometriosis and moderate-to-severe endometriosis seems to be different. Increased sFlt-1 levels in serum and urine of minimal-to-mild disease indicate that sFlt-1 may have an important role in inhibiting angiogenic process of the disease.",
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Evaluation of serum and urinary angiogenic factors in patients with endometriosis. / Cho, Si Hyun; Oh, Yoon Jin; Nam, Anna; Kim, Hye Yeon; Park, Joo Hyun; Kim, Jae-Hoon; Park, Ki Hyun; Cho, Dong Je; Lee, Byung Seok.

In: American Journal of Reproductive Immunology, Vol. 58, No. 6, 01.12.2007, p. 497-504.

Research output: Contribution to journalArticle

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AU - Cho, Si Hyun

AU - Oh, Yoon Jin

AU - Nam, Anna

AU - Kim, Hye Yeon

AU - Park, Joo Hyun

AU - Kim, Jae-Hoon

AU - Park, Ki Hyun

AU - Cho, Dong Je

AU - Lee, Byung Seok

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N2 - Problem: The aim of this study was to evaluate serum and urinary levels of vascular endothelial growth factors, tumor necrosis factor-α (TNF-α), and soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis. Method of study: During surgery for pelvic pain, pelvic mass or infertility, serum and urine were collected. Of 70 patients, 46 had histology-proven endometriosis and 24 patients without endometriosis participated as controls. Results: Serum TNF-α levels and urinarysFlt-1 levels corrected for creatinine excretion were significantly increased in the endometriosis group (P = 0.001 and P = 0.011 respectively). Serum sFlt-1 levels and urinary sFlt-1 levels corrected for creatinine were significantly higher in patients with minimal-to-mild disease (P = 0.014 and P = 0.015 respectively), where serum TNF-α levels were increased in moderate-to-severe endometriosis (P < 0.001). Conclusion: The pathogenesis of minimal-to-mild endometriosis and moderate-to-severe endometriosis seems to be different. Increased sFlt-1 levels in serum and urine of minimal-to-mild disease indicate that sFlt-1 may have an important role in inhibiting angiogenic process of the disease.

AB - Problem: The aim of this study was to evaluate serum and urinary levels of vascular endothelial growth factors, tumor necrosis factor-α (TNF-α), and soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis. Method of study: During surgery for pelvic pain, pelvic mass or infertility, serum and urine were collected. Of 70 patients, 46 had histology-proven endometriosis and 24 patients without endometriosis participated as controls. Results: Serum TNF-α levels and urinarysFlt-1 levels corrected for creatinine excretion were significantly increased in the endometriosis group (P = 0.001 and P = 0.011 respectively). Serum sFlt-1 levels and urinary sFlt-1 levels corrected for creatinine were significantly higher in patients with minimal-to-mild disease (P = 0.014 and P = 0.015 respectively), where serum TNF-α levels were increased in moderate-to-severe endometriosis (P < 0.001). Conclusion: The pathogenesis of minimal-to-mild endometriosis and moderate-to-severe endometriosis seems to be different. Increased sFlt-1 levels in serum and urine of minimal-to-mild disease indicate that sFlt-1 may have an important role in inhibiting angiogenic process of the disease.

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