Evaluation of the antimicrobial activity of florfenicol against bacteria isolated from bovine and porcine respiratory disease

SungJae Shin, Sang Gyun Kang, Rayamajhi Nabin, Mi Lan Kang, Han Sang Yoo

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Antimicrobial susceptibility of florfenicol (FFC) against 243 bacterial agents isolated in Korea from cattle and pigs with respiratory disease were investigated by agar diffusion and microdilution broth methods following the recommendations provided by the National Committee for Clinical Laboratory Standards. All Actinobacillus pleuropnemoniae, Pasteurella multocida, Mannheimia haemolytica and 98.6% of the Bordetella bronchiseptica isolates were susceptible to FFC, which as significantly more effective than the other antibiotics used in this study. FFC also showed high in vitro antimicrobial activities (MIC90 ≤ 1 μg/ml) against all strains tested with a minimal inhibitory concentration (MIC) determination ranging from 0.12 to 4 μg/ml. No resistant strains of A. pleuropneumoniae, P. multocida and M. haemolytica to FFC have apparently developed since the first introduction of this antibiotics for veterinary use in Korea. The results suggest that FFC is therapeutically valuable in the treatment of primary or complicating bacterial pathogens causing of the bovine and swine respiratory tract.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalVeterinary Microbiology
Volume106
Issue number1-2
DOIs
Publication statusPublished - 2005 Mar 20

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Swine Diseases
florfenicol
respiratory tract diseases
Mannheimia haemolytica
anti-infective agents
Bacteria
swine
cattle
bacteria
Pasteurella multocida
Korea
Korean Peninsula
Swine
Actinobacillus
Pleuropneumonia
antibiotics
Bordetella bronchiseptica
Anti-Bacterial Agents
minimum inhibitory concentration
respiratory system

All Science Journal Classification (ASJC) codes

  • Microbiology
  • veterinary(all)

Cite this

Shin, SungJae ; Kang, Sang Gyun ; Nabin, Rayamajhi ; Kang, Mi Lan ; Yoo, Han Sang. / Evaluation of the antimicrobial activity of florfenicol against bacteria isolated from bovine and porcine respiratory disease. In: Veterinary Microbiology. 2005 ; Vol. 106, No. 1-2. pp. 73-77.
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Evaluation of the antimicrobial activity of florfenicol against bacteria isolated from bovine and porcine respiratory disease. / Shin, SungJae; Kang, Sang Gyun; Nabin, Rayamajhi; Kang, Mi Lan; Yoo, Han Sang.

In: Veterinary Microbiology, Vol. 106, No. 1-2, 20.03.2005, p. 73-77.

Research output: Contribution to journalArticle

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