Evaluation of the antimicrobial activity of florfenicol against bacteria isolated from bovine and porcine respiratory disease

Sung Jae Shin, Sang Gyun Kang, Rayamajhi Nabin, Mi Lan Kang, Han Sang Yoo

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Antimicrobial susceptibility of florfenicol (FFC) against 243 bacterial agents isolated in Korea from cattle and pigs with respiratory disease were investigated by agar diffusion and microdilution broth methods following the recommendations provided by the National Committee for Clinical Laboratory Standards. All Actinobacillus pleuropnemoniae, Pasteurella multocida, Mannheimia haemolytica and 98.6% of the Bordetella bronchiseptica isolates were susceptible to FFC, which as significantly more effective than the other antibiotics used in this study. FFC also showed high in vitro antimicrobial activities (MIC90 ≤ 1 μg/ml) against all strains tested with a minimal inhibitory concentration (MIC) determination ranging from 0.12 to 4 μg/ml. No resistant strains of A. pleuropneumoniae, P. multocida and M. haemolytica to FFC have apparently developed since the first introduction of this antibiotics for veterinary use in Korea. The results suggest that FFC is therapeutically valuable in the treatment of primary or complicating bacterial pathogens causing of the bovine and swine respiratory tract.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalVeterinary Microbiology
Volume106
Issue number1-2
DOIs
Publication statusPublished - 2005 Mar 20

All Science Journal Classification (ASJC) codes

  • Microbiology
  • veterinary(all)

Fingerprint Dive into the research topics of 'Evaluation of the antimicrobial activity of florfenicol against bacteria isolated from bovine and porcine respiratory disease'. Together they form a unique fingerprint.

  • Cite this