Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals

Ki Bum Won, Donghee Han, Ji Hyun Lee, Sang Eun Lee, Ji Min Sung, Su Yeon Choi, Eun Ju Chun, Sung Hak Park, Hae Won Han, Jidong Sung, Hae Ok Jung, Hyuk Jae Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited. Methods: Data from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry on 12,441 asymptomatic Korean adults (52 ± 9 years, 84.2% males) without previous history of coronary artery disease and stroke, who underwent serial coronary artery calcification (CAC) screening examinations, were included in this study. The median inter-scan period was 3.0 (2.0-4.8) years. All participants were categorized into three groups based on their glycemic status: normal (n = 6578), pre-diabetes (n = 4146), and diabetes (n = 1717). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CAC scores. Results: The incidence of CAC progression was significantly different between the three groups (normal, 26.3%; pre-diabetes, 30.9%; and diabetes, 46.9%; p < 0.001). In the univariate logistic analysis, the risk of CAC progression was higher in the pre-diabetes (odds ratio [OR] 1.253; 95% confidential interval [CI] 1.150-1.366) and diabetes (OR 2.471; 95% CI 2.215-2.758) groups than in the normal group (p < 0.001, both). In the multivariate logistic analysis, the risk of CAC progression was not significantly different between the normal and pre-diabetes groups but was significantly higher in the diabetes group than in the normal group. Conclusions: In asymptomatic subjects, diabetes had an incremental impact on CAC progression; however, prediabetes did not increase the risk of CAC progression after adjusting for confounding factors.

Original languageEnglish
Article number4
JournalCardiovascular Diabetology
Volume17
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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Coronary Vessels
Odds Ratio
Prediabetic State
Korea
Registries
Coronary Artery Disease
Multivariate Analysis
Stroke
Incidence

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Won, Ki Bum ; Han, Donghee ; Lee, Ji Hyun ; Lee, Sang Eun ; Sung, Ji Min ; Choi, Su Yeon ; Chun, Eun Ju ; Park, Sung Hak ; Han, Hae Won ; Sung, Jidong ; Jung, Hae Ok ; Chang, Hyuk Jae. / Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals. In: Cardiovascular Diabetology. 2018 ; Vol. 17, No. 1.
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title = "Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals",
abstract = "Background: Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited. Methods: Data from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry on 12,441 asymptomatic Korean adults (52 ± 9 years, 84.2{\%} males) without previous history of coronary artery disease and stroke, who underwent serial coronary artery calcification (CAC) screening examinations, were included in this study. The median inter-scan period was 3.0 (2.0-4.8) years. All participants were categorized into three groups based on their glycemic status: normal (n = 6578), pre-diabetes (n = 4146), and diabetes (n = 1717). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CAC scores. Results: The incidence of CAC progression was significantly different between the three groups (normal, 26.3{\%}; pre-diabetes, 30.9{\%}; and diabetes, 46.9{\%}; p < 0.001). In the univariate logistic analysis, the risk of CAC progression was higher in the pre-diabetes (odds ratio [OR] 1.253; 95{\%} confidential interval [CI] 1.150-1.366) and diabetes (OR 2.471; 95{\%} CI 2.215-2.758) groups than in the normal group (p < 0.001, both). In the multivariate logistic analysis, the risk of CAC progression was not significantly different between the normal and pre-diabetes groups but was significantly higher in the diabetes group than in the normal group. Conclusions: In asymptomatic subjects, diabetes had an incremental impact on CAC progression; however, prediabetes did not increase the risk of CAC progression after adjusting for confounding factors.",
author = "Won, {Ki Bum} and Donghee Han and Lee, {Ji Hyun} and Lee, {Sang Eun} and Sung, {Ji Min} and Choi, {Su Yeon} and Chun, {Eun Ju} and Park, {Sung Hak} and Han, {Hae Won} and Jidong Sung and Jung, {Hae Ok} and Chang, {Hyuk Jae}",
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Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals. / Won, Ki Bum; Han, Donghee; Lee, Ji Hyun; Lee, Sang Eun; Sung, Ji Min; Choi, Su Yeon; Chun, Eun Ju; Park, Sung Hak; Han, Hae Won; Sung, Jidong; Jung, Hae Ok; Chang, Hyuk Jae.

In: Cardiovascular Diabetology, Vol. 17, No. 1, 4, 01.01.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals

AU - Won, Ki Bum

AU - Han, Donghee

AU - Lee, Ji Hyun

AU - Lee, Sang Eun

AU - Sung, Ji Min

AU - Choi, Su Yeon

AU - Chun, Eun Ju

AU - Park, Sung Hak

AU - Han, Hae Won

AU - Sung, Jidong

AU - Jung, Hae Ok

AU - Chang, Hyuk Jae

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited. Methods: Data from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry on 12,441 asymptomatic Korean adults (52 ± 9 years, 84.2% males) without previous history of coronary artery disease and stroke, who underwent serial coronary artery calcification (CAC) screening examinations, were included in this study. The median inter-scan period was 3.0 (2.0-4.8) years. All participants were categorized into three groups based on their glycemic status: normal (n = 6578), pre-diabetes (n = 4146), and diabetes (n = 1717). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CAC scores. Results: The incidence of CAC progression was significantly different between the three groups (normal, 26.3%; pre-diabetes, 30.9%; and diabetes, 46.9%; p < 0.001). In the univariate logistic analysis, the risk of CAC progression was higher in the pre-diabetes (odds ratio [OR] 1.253; 95% confidential interval [CI] 1.150-1.366) and diabetes (OR 2.471; 95% CI 2.215-2.758) groups than in the normal group (p < 0.001, both). In the multivariate logistic analysis, the risk of CAC progression was not significantly different between the normal and pre-diabetes groups but was significantly higher in the diabetes group than in the normal group. Conclusions: In asymptomatic subjects, diabetes had an incremental impact on CAC progression; however, prediabetes did not increase the risk of CAC progression after adjusting for confounding factors.

AB - Background: Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited. Methods: Data from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry on 12,441 asymptomatic Korean adults (52 ± 9 years, 84.2% males) without previous history of coronary artery disease and stroke, who underwent serial coronary artery calcification (CAC) screening examinations, were included in this study. The median inter-scan period was 3.0 (2.0-4.8) years. All participants were categorized into three groups based on their glycemic status: normal (n = 6578), pre-diabetes (n = 4146), and diabetes (n = 1717). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CAC scores. Results: The incidence of CAC progression was significantly different between the three groups (normal, 26.3%; pre-diabetes, 30.9%; and diabetes, 46.9%; p < 0.001). In the univariate logistic analysis, the risk of CAC progression was higher in the pre-diabetes (odds ratio [OR] 1.253; 95% confidential interval [CI] 1.150-1.366) and diabetes (OR 2.471; 95% CI 2.215-2.758) groups than in the normal group (p < 0.001, both). In the multivariate logistic analysis, the risk of CAC progression was not significantly different between the normal and pre-diabetes groups but was significantly higher in the diabetes group than in the normal group. Conclusions: In asymptomatic subjects, diabetes had an incremental impact on CAC progression; however, prediabetes did not increase the risk of CAC progression after adjusting for confounding factors.

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