Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals

Ki Bum Won, Donghee Han, Ji Hyun Lee, Sang Eun Lee, Ji Min Sung, Su Yeon Choi, Eun Ju Chun, Sung Hak Park, Hae Won Han, Jidong Sung, Hae Ok Jung, Hyuk Jae Chang

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Abstract

Background: Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited. Methods: Data from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry on 12,441 asymptomatic Korean adults (52 ± 9 years, 84.2% males) without previous history of coronary artery disease and stroke, who underwent serial coronary artery calcification (CAC) screening examinations, were included in this study. The median inter-scan period was 3.0 (2.0-4.8) years. All participants were categorized into three groups based on their glycemic status: normal (n = 6578), pre-diabetes (n = 4146), and diabetes (n = 1717). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CAC scores. Results: The incidence of CAC progression was significantly different between the three groups (normal, 26.3%; pre-diabetes, 30.9%; and diabetes, 46.9%; p < 0.001). In the univariate logistic analysis, the risk of CAC progression was higher in the pre-diabetes (odds ratio [OR] 1.253; 95% confidential interval [CI] 1.150-1.366) and diabetes (OR 2.471; 95% CI 2.215-2.758) groups than in the normal group (p < 0.001, both). In the multivariate logistic analysis, the risk of CAC progression was not significantly different between the normal and pre-diabetes groups but was significantly higher in the diabetes group than in the normal group. Conclusions: In asymptomatic subjects, diabetes had an incremental impact on CAC progression; however, prediabetes did not increase the risk of CAC progression after adjusting for confounding factors.

Original languageEnglish
Article number4
JournalCardiovascular Diabetology
Volume17
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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    Won, K. B., Han, D., Lee, J. H., Lee, S. E., Sung, J. M., Choi, S. Y., Chun, E. J., Park, S. H., Han, H. W., Sung, J., Jung, H. O., & Chang, H. J. (2018). Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals. Cardiovascular Diabetology, 17(1), [4]. https://doi.org/10.1186/s12933-017-0653-0