Evaluation of the international society for cutaneous lymphoma algorithm for the diagnosis of early mycosis fungoides

Hyang Joo Ryu, Sun Il Kim, Hyung Ook Jang, Se Hoon Kim, Sang Ho Oh, Sujin Park, Sang Kyum Kim

Research output: Contribution to journalArticlepeer-review

Abstract

The International Society for Cutaneous Lymphoma (ISCL) proposes a diagnostic algorithm for early mycosis fungoides (MF) that includes clinical, histological, immunophenotypical, and molecular criteria. Here, we analyzed the immunologic markers and features of T-cell clonality in 38 early MF cases and 22 non-MF cases to validate the ISCL algorithm. We found that CD5 and CD7 expression differed significantly between early MF and non-MF cases, with epidermal discordance of CD7 expression more frequently identified in early MF. Notably, increasing the cut-off value for CD7 expression from 10% to 22.5% improved its sensitivity. Furthermore, TCR-γ and β chain rearrangements were more frequently detected in early MF than in non-MF cases. Based on these findings, we propose CD5 and CD7 deficiency as mandatory immunopathologic criteria and PCR-based testing for TCR-γ and β chains as required molecular/biologic criteria to improve the efficiency of early MF diagnosis using the ISCL algorithm.

Original languageEnglish
Article number2758
JournalCells
Volume10
Issue number10
DOIs
Publication statusPublished - 2021 Oct

Bibliographical note

Funding Information:
Funding: This research was funded by the Basic Science Research Program through the National Research Foundation of Korea (NRF), grant number 2020R1F1A1076774 (S.-K.K.).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Evaluation of the international society for cutaneous lymphoma algorithm for the diagnosis of early mycosis fungoides'. Together they form a unique fingerprint.

Cite this