Evaluation of the potential clinical application of low-intensity ultrasound stimulation for preventing osteoporotic bone fracture

Dae Gon Woo, Chang Yong Ko, Hansung Kim, Jongbum Seo, Dohyung Lim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study evaluated the possible clinical application of low-intensity ultrasound (LIUS) stimulation for preventing osteoporotic bone fracture. Eight virgin 14-week-old ICR mice (weight 24.0 ± 0.7 g) were ovariectomized to induce osteoporosis. The right hind limbs (US limbs) were stimulated with LIUS, whereas the left hind limbs (CON limbs) were not stimulated. LIUS was applied for 20 min a day, 5 days a week over a 6-week period using the following parameters: 1.5 MHz frequency, 1.0 kHz pulse repetition, 30 mW/cm2 intensity, and 200 ls pulse length. The effective structural modulus increased significantly (p>0.05) in the US limbs over time with the increased bone quantity, whereas that in CON limbs remained statistically constant (p<0.05). In addition, the elastic modulus in the US limbs was generally enhanced by an increased bone quality, compared with the CON limbs. Therefore, LIUS stimulation may effectively reduce the risk of osteoporotic bone fracture by increasing the mechanical characteristics of bone via improvements in both the effective structural and elastic modulus of the osteoporotic bone. In conclusion, LIUS may potentially prove very effective clinically for preventing osteoporotic bone fractures.

Original languageEnglish
Pages (from-to)2438-2446
Number of pages9
JournalAnnals of Biomedical Engineering
Volume38
Issue number7
DOIs
Publication statusPublished - 2010 Jul 1

Fingerprint

Bone
Ultrasonics
Elastic moduli

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

@article{f294bb8881f24d7b950a2765125973fd,
title = "Evaluation of the potential clinical application of low-intensity ultrasound stimulation for preventing osteoporotic bone fracture",
abstract = "This study evaluated the possible clinical application of low-intensity ultrasound (LIUS) stimulation for preventing osteoporotic bone fracture. Eight virgin 14-week-old ICR mice (weight 24.0 ± 0.7 g) were ovariectomized to induce osteoporosis. The right hind limbs (US limbs) were stimulated with LIUS, whereas the left hind limbs (CON limbs) were not stimulated. LIUS was applied for 20 min a day, 5 days a week over a 6-week period using the following parameters: 1.5 MHz frequency, 1.0 kHz pulse repetition, 30 mW/cm2 intensity, and 200 ls pulse length. The effective structural modulus increased significantly (p>0.05) in the US limbs over time with the increased bone quantity, whereas that in CON limbs remained statistically constant (p<0.05). In addition, the elastic modulus in the US limbs was generally enhanced by an increased bone quality, compared with the CON limbs. Therefore, LIUS stimulation may effectively reduce the risk of osteoporotic bone fracture by increasing the mechanical characteristics of bone via improvements in both the effective structural and elastic modulus of the osteoporotic bone. In conclusion, LIUS may potentially prove very effective clinically for preventing osteoporotic bone fractures.",
author = "Woo, {Dae Gon} and Ko, {Chang Yong} and Hansung Kim and Jongbum Seo and Dohyung Lim",
year = "2010",
month = "7",
day = "1",
doi = "10.1007/s10439-010-9983-8",
language = "English",
volume = "38",
pages = "2438--2446",
journal = "Annals of Biomedical Engineering",
issn = "0090-6964",
publisher = "Springer Netherlands",
number = "7",

}

Evaluation of the potential clinical application of low-intensity ultrasound stimulation for preventing osteoporotic bone fracture. / Woo, Dae Gon; Ko, Chang Yong; Kim, Hansung; Seo, Jongbum; Lim, Dohyung.

In: Annals of Biomedical Engineering, Vol. 38, No. 7, 01.07.2010, p. 2438-2446.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of the potential clinical application of low-intensity ultrasound stimulation for preventing osteoporotic bone fracture

AU - Woo, Dae Gon

AU - Ko, Chang Yong

AU - Kim, Hansung

AU - Seo, Jongbum

AU - Lim, Dohyung

PY - 2010/7/1

Y1 - 2010/7/1

N2 - This study evaluated the possible clinical application of low-intensity ultrasound (LIUS) stimulation for preventing osteoporotic bone fracture. Eight virgin 14-week-old ICR mice (weight 24.0 ± 0.7 g) were ovariectomized to induce osteoporosis. The right hind limbs (US limbs) were stimulated with LIUS, whereas the left hind limbs (CON limbs) were not stimulated. LIUS was applied for 20 min a day, 5 days a week over a 6-week period using the following parameters: 1.5 MHz frequency, 1.0 kHz pulse repetition, 30 mW/cm2 intensity, and 200 ls pulse length. The effective structural modulus increased significantly (p>0.05) in the US limbs over time with the increased bone quantity, whereas that in CON limbs remained statistically constant (p<0.05). In addition, the elastic modulus in the US limbs was generally enhanced by an increased bone quality, compared with the CON limbs. Therefore, LIUS stimulation may effectively reduce the risk of osteoporotic bone fracture by increasing the mechanical characteristics of bone via improvements in both the effective structural and elastic modulus of the osteoporotic bone. In conclusion, LIUS may potentially prove very effective clinically for preventing osteoporotic bone fractures.

AB - This study evaluated the possible clinical application of low-intensity ultrasound (LIUS) stimulation for preventing osteoporotic bone fracture. Eight virgin 14-week-old ICR mice (weight 24.0 ± 0.7 g) were ovariectomized to induce osteoporosis. The right hind limbs (US limbs) were stimulated with LIUS, whereas the left hind limbs (CON limbs) were not stimulated. LIUS was applied for 20 min a day, 5 days a week over a 6-week period using the following parameters: 1.5 MHz frequency, 1.0 kHz pulse repetition, 30 mW/cm2 intensity, and 200 ls pulse length. The effective structural modulus increased significantly (p>0.05) in the US limbs over time with the increased bone quantity, whereas that in CON limbs remained statistically constant (p<0.05). In addition, the elastic modulus in the US limbs was generally enhanced by an increased bone quality, compared with the CON limbs. Therefore, LIUS stimulation may effectively reduce the risk of osteoporotic bone fracture by increasing the mechanical characteristics of bone via improvements in both the effective structural and elastic modulus of the osteoporotic bone. In conclusion, LIUS may potentially prove very effective clinically for preventing osteoporotic bone fractures.

UR - http://www.scopus.com/inward/record.url?scp=77954657169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954657169&partnerID=8YFLogxK

U2 - 10.1007/s10439-010-9983-8

DO - 10.1007/s10439-010-9983-8

M3 - Article

VL - 38

SP - 2438

EP - 2446

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

SN - 0090-6964

IS - 7

ER -