Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma

Wungrak Choi, Hyoung Won Bae, Hyuna Cho, Eun Woo Kim, Chan Yun Kim, Gong Je Seong

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This study evaluated age-related trabecular meshwork (TM) height variations in the eyes of adults in different age groups. We hypothesised that a reduction in TM occurs with increasing age. This retrospective, cross-sectional, observational study was conducted at Yonsei University Gangnam Severance Hospital between January 2015 and June 2019. We randomly included 250 eyes of 125 patients who underwent anterior segment optical coherence tomography (AS-OCT). The distance from the scleral spur to Schwalbe’s line in patients with normal open anterior chamber angle was measured using AS-OCT. Results were stratified based on patients’ age group—≤40, 41–50, 51–60, 61–70, 71–80, and 81–92 years. Thereafter, the results were compared among the age groups. The mean TM height of the patients was 770.929 ± 76.776 μm. TM height was 853.188 ± 94.117 μm in patients aged ≤40 years; it was 815.309 ± 75.723, 798.115 ± 66.040, 770.942 ± 52.774, 726.716 ± 63.979, and 715.968 ± 63.403 μm in patients aged 41–50, 51–60, 61–70, 71–80, and 81–92 years, respectively. The TM height tended to decrease with increasing age (P < 0.001). TM height was significantly shorter in older patients than in younger ones. Therefore, TM height may change with age and may contribute to increased glaucoma risk and prevalence.

Original languageEnglish
Article number7115
JournalScientific reports
Issue number1
Publication statusPublished - 2020 Dec 1

Bibliographical note

Funding Information:
The authors are grateful to Joo Young Park and Si Nae Kim (Department of Research Affairs, Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea) for their help with the statistical analyses. This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) [No. NRF-2017 R1A2B4012212] and [NRF-2019R1I1A1A01061721]. The funding organisation had no role in the design or conducting of this research.

Publisher Copyright:
© 2020, The Author(s).

All Science Journal Classification (ASJC) codes

  • General


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