Evaluation of tissue adhesion preventive surface modified natural and synthetic polymeric materials

Hwal Suh, Si Nae Park, Jung Hyun Kim

Research output: Contribution to journalConference article

2 Citations (Scopus)

Abstract

The poly (ethylene glycol)-poly (L-lactide) (PEG-PLGA) film/collagen-hyaluronic acid (HA) composite material was newly developed as a tissue adhesion preventive membrane. In this study, the effects of the composite matrix on the cell adhesion and proliferation were evaluated. Fibroblasts attached better on the collagen-HA matrix than on Interceed™ or PEG-PLGA film. PEG-PLGA showed very low cell adhesive property. SEM observations revealed that the fibroblasts attached evenly on the collagen-HA matrix due to its high water uptake ability and hydrophilicity. In confocal microscopic observation, it was shown that actin microfilaments of fibroblasts were further polymerized on the collagen-HA membrane compared to those on the PEG-PLGA membrane and Interceed™. The proliferation test showed that proliferation of fibroblasts was enhanced by collagen-HA matrix. However, very few attached cells were found on the surface of the PEG-PLGA film after 7-day incubation. Therefore, the bioresorbable composite material containing collagen-HA matrix side, which was designed for the damaged layer of peritoneum and PEG-PLGA film side for preventing tissue adhesion, could be proposed as a novel adhesion barrier membrane.

Original languageEnglish
Pages (from-to)3255-3260
Number of pages6
JournalMaterials Science Forum
Volume426-432
Issue number4
Publication statusPublished - 2003 Jul 18
EventThermec 2003 Processing and Manufacturing of Advanced Materials - Madrid, Spain
Duration: 2003 Jul 72003 Jul 11

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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