Evaluation of tissue adhesion preventive surface modified natural and synthetic polymeric materials

Hwal Suh, Si Nae Park, Jung Hyun Kim

Research output: Contribution to journalConference article

2 Citations (Scopus)

Abstract

The poly (ethylene glycol)-poly (L-lactide) (PEG-PLGA) film/collagen-hyaluronic acid (HA) composite material was newly developed as a tissue adhesion preventive membrane. In this study, the effects of the composite matrix on the cell adhesion and proliferation were evaluated. Fibroblasts attached better on the collagen-HA matrix than on Interceed™ or PEG-PLGA film. PEG-PLGA showed very low cell adhesive property. SEM observations revealed that the fibroblasts attached evenly on the collagen-HA matrix due to its high water uptake ability and hydrophilicity. In confocal microscopic observation, it was shown that actin microfilaments of fibroblasts were further polymerized on the collagen-HA membrane compared to those on the PEG-PLGA membrane and Interceed™. The proliferation test showed that proliferation of fibroblasts was enhanced by collagen-HA matrix. However, very few attached cells were found on the surface of the PEG-PLGA film after 7-day incubation. Therefore, the bioresorbable composite material containing collagen-HA matrix side, which was designed for the damaged layer of peritoneum and PEG-PLGA film side for preventing tissue adhesion, could be proposed as a novel adhesion barrier membrane.

Original languageEnglish
Pages (from-to)3255-3260
Number of pages6
JournalMaterials Science Forum
Volume426-432
Issue number4
Publication statusPublished - 2003 Jul 18
EventThermec 2003 Processing and Manufacturing of Advanced Materials - Madrid, Spain
Duration: 2003 Jul 72003 Jul 11

Fingerprint

Hyaluronic acid
Hyaluronic Acid
collagens
Polyethylene glycols
Collagen
adhesion
Adhesion
fibroblasts
Fibroblasts
Tissue
acids
evaluation
Polymers
membranes
Membranes
matrices
composite materials
peritoneum
Composite materials
cells

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

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abstract = "The poly (ethylene glycol)-poly (L-lactide) (PEG-PLGA) film/collagen-hyaluronic acid (HA) composite material was newly developed as a tissue adhesion preventive membrane. In this study, the effects of the composite matrix on the cell adhesion and proliferation were evaluated. Fibroblasts attached better on the collagen-HA matrix than on Interceed™ or PEG-PLGA film. PEG-PLGA showed very low cell adhesive property. SEM observations revealed that the fibroblasts attached evenly on the collagen-HA matrix due to its high water uptake ability and hydrophilicity. In confocal microscopic observation, it was shown that actin microfilaments of fibroblasts were further polymerized on the collagen-HA membrane compared to those on the PEG-PLGA membrane and Interceed™. The proliferation test showed that proliferation of fibroblasts was enhanced by collagen-HA matrix. However, very few attached cells were found on the surface of the PEG-PLGA film after 7-day incubation. Therefore, the bioresorbable composite material containing collagen-HA matrix side, which was designed for the damaged layer of peritoneum and PEG-PLGA film side for preventing tissue adhesion, could be proposed as a novel adhesion barrier membrane.",
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Evaluation of tissue adhesion preventive surface modified natural and synthetic polymeric materials. / Suh, Hwal; Park, Si Nae; Kim, Jung Hyun.

In: Materials Science Forum, Vol. 426-432, No. 4, 18.07.2003, p. 3255-3260.

Research output: Contribution to journalConference article

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