Evaluation of ultrasound tissue damage based on changes in image echogenicity

J. Seo, B. C. Tran, T. L. Hall, J. B. Fowlkes, M. O'Donnell, C. A. Cain

Research output: Contribution to journalConference articlepeer-review

10 Citations (Scopus)


The rate of decay of increased echogenicity of the focal zone insonified in vivo canine kidney was quantified and parameterized to evaluate tissue damage. High intensity focused sonification was conducted at high mechanical index in order to assure onset of cavitation. A 2D local correlation method was applied to trace temporal change at each location and for motion compensation. The decay half time of increased echo, thalf, defined as the time for echo enhancement to decay by a factor of 2, was measured. The average thalf determined from 23 occurrences of tissue damage, characterized by coagulation necrosis, pitting, and/or blanching, was approximately 45 seconds. On the other hand, when increased echogenicity decayed significantly faster, the observed damage, if present at all, was limited to minor hemorrhage. In 18 cases where increased echogenicity was observed and associated tissue damage was not found, the average thalf was approximately 13 seconds. The correlation between the decay half time and the observed tissue damage is presented and may provide a useful method for both pre-treatment localization and post-treatment evaluation for non-invasive ultrasound surgery.

Original languageEnglish
Pages (from-to)1431-1434
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
Publication statusPublished - 2002
Event2002 IEEE Ultrasonics Symposium - Munich, Germany
Duration: 2002 Oct 82002 Oct 11

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics


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