Evaluation of urinary nucleosides in breast cancer patients before and after tumor removal

Sung Hee Cho, Man Ho Choi, Won Yong Lee, Bong Chul Chung

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objective: Evaluation of altered urinary nucleosides before and after tumor removal of breast cancer (BCa). Design and methods: Targeted metabolite profiling of 14 urinary nucleosides was conducted with both pre- and post-operative female patients with BCa (n = 150, age: 46.6 ± 7.7 years), and female controls (n = 150, age: 46.8 ± 7.7 years) by liquid chromatography-tandem mass spectrometry coupled to on-line extraction. Results: Levels of modified nucleosides (5-hydroxymethyl-2′-deoxyuridine, P < 0.001; 8-hydroxy-2′-deoxyguanosine, P < 0.001; 1-methyladenosine, P < 0.02; N2,N2-dimethylguanosine, P < 0.001) were significantly higher in pre-operative patients than in both normal controls and post-operative patients. Conclusions: This approach could be used to further understand the pathogenesis of BCa as well as to evaluate the effects of medical treatment.

Original languageEnglish
Pages (from-to)540-543
Number of pages4
JournalClinical Biochemistry
Volume42
Issue number6
DOIs
Publication statusPublished - 2009 Apr

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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