Evolutionary architecture of the infant-adapted group of Bifidobacterium species associated with the probiotic function

Min Jung Kwak, Soon Kyeong Kwon, Jae Kyung Yoon, Ju Yeon Song, Jae Gu Seo, Myung Jun Chung, Jihyun F. Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Bifidobacteria, often associated with the gastrointestinal tract of animals, are well known for their roles as probiotics. Among the dozens of Bifidobacterium species, Bifidobacterium bifidum, B. breve, and B. longum are the ones most frequently isolated from the feces of infants and known to help the digestion of human milk oligosaccharides. To investigate the correlation between the metabolic properties of bifidobacteria and their phylogeny, we performed a phylogenomic analysis based on 452 core genes of forty-four completely sequenced Bifidobacterium species. Results show that a major evolutionary event leading to the clade of the infant-adapted species is linked to carbohydrate metabolism, but it is not the only factor responsible for the adaptation of bifidobacteria to the gut. The genome of B. longum subsp. infantis, a typical bifidobacterium in the gut of breast-fed infants, encodes proteins associated with several kinds of species-specific metabolic pathways, including urea metabolism and biosynthesis of riboflavin and lantibiotics. Our results demonstrate that these metabolic features, which are associated with the probiotic function of bifidobacteria, are species-specific and highly correlate with their phylogeny.

Original languageEnglish
Pages (from-to)429-439
Number of pages11
JournalSystematic and Applied Microbiology
Volume39
Issue number7
DOIs
Publication statusPublished - 2016 Oct 1

Fingerprint

Bifidobacterium
probiotics
Probiotics
phylogeny
metabolism
Phylogeny
Bifidobacterium longum subsp. infantis
digestive system
Bifidobacterium breve
Bifidobacterium bifidum
Bifidobacterium longum
feces
milk
urea
bacteriocins
Bacteriocins
carbohydrate metabolism
riboflavin
breast milk
digestion

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology

Cite this

Kwak, Min Jung ; Kwon, Soon Kyeong ; Yoon, Jae Kyung ; Song, Ju Yeon ; Seo, Jae Gu ; Chung, Myung Jun ; Kim, Jihyun F. / Evolutionary architecture of the infant-adapted group of Bifidobacterium species associated with the probiotic function. In: Systematic and Applied Microbiology. 2016 ; Vol. 39, No. 7. pp. 429-439.
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Evolutionary architecture of the infant-adapted group of Bifidobacterium species associated with the probiotic function. / Kwak, Min Jung; Kwon, Soon Kyeong; Yoon, Jae Kyung; Song, Ju Yeon; Seo, Jae Gu; Chung, Myung Jun; Kim, Jihyun F.

In: Systematic and Applied Microbiology, Vol. 39, No. 7, 01.10.2016, p. 429-439.

Research output: Contribution to journalArticle

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