Evolving artificial neural networks for DNA microarray analysis

Kyung Joong Kim, Sung Bae Cho

Research output: Contribution to conferencePaper

1 Citation (Scopus)

Abstract

DNA microarray technology provides a format for the simultaneous measurement of the expression level of thousands of genes in a single hybridization assay. One exciting result of microarray technology has been the demonstration that patterns of gene expression can distinguish between tumors of different anatomical origins. Standard statistical methodologies in classification and prediction do not work well or even at all when N (the number of samples) < p (genes). Modification of existing statistical methodologies or development of new methodologies are needed for the analysis of cancer. Recently, designing artificial neural networks (ANNs) by evolutionary algorithms has emerged as a preferred alternative to the common practice of selecting the apparent best network. We propose an evolutionary neural network that classifies gene expression profiles into normal or colon cancer cell. Colon cancer is the second only to lung cancer as a cause of cancer-related mortality in Western countries. Colon cancer is a genetic disease, propagated by the acquisition of somatic alterations that influence gene expression. Experimental results on colon microarray data with evolutionary neural network show that the proposed method can perform better than other classifiers. Contribution of this article is applying evolutionary neural network to gene expression classification problem.

Original languageEnglish
Pages2370-2377
Number of pages8
DOIs
Publication statusPublished - 2003
Event2003 Congress on Evolutionary Computation, CEC 2003 - Canberra, ACT, Australia
Duration: 2003 Dec 82003 Dec 12

Other

Other2003 Congress on Evolutionary Computation, CEC 2003
CountryAustralia
CityCanberra, ACT
Period03/12/803/12/12

All Science Journal Classification (ASJC) codes

  • Computational Mathematics

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    Kim, K. J., & Cho, S. B. (2003). Evolving artificial neural networks for DNA microarray analysis. 2370-2377. Paper presented at 2003 Congress on Evolutionary Computation, CEC 2003, Canberra, ACT, Australia. https://doi.org/10.1109/CEC.2003.1299384